Human soluble ACE2 improves the effect of remdesivir in SARS‐CoV‐2 infection

There is a critical need for safe and effective drugs for COVID‐19. Only remdesivir has received authorization for COVID‐19 and has been shown to improve outcomes but not decrease mortality. However, the dose of remdesivir is limited by hepatic and kidney toxicity. ACE2 is the critical cell surface...

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Veröffentlicht in:	EMBO molecular medicine Jg. 13; H. 1; S. e13426 - n/a
Hauptverfasser:	Monteil, Vanessa, Dyczynski, Matheus, Lauschke, Volker M, Kwon, Hyesoo, Wirnsberger, Gerald, Youhanna, Sonia, Zhang, Haibo, Slutsky, Arthur S, Hurtado del Pozo, Carmen, Horn, Moritz, Montserrat, Nuria, Penninger, Josef M, Mirazimi, Ali
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 11.01.2021 EMBO Press John Wiley and Sons Inc Springer Nature
Schlagworte:	ACE2 Adenosine Monophosphate - analogs & derivatives Adenosine Monophosphate - pharmacology Adenylate kinase Alanine - analogs & derivatives Alanine - pharmacology Angiotensin-converting enzyme 2 Angiotensin-Converting Enzyme 2 - pharmacology Animals Antiviral Agents - pharmacology Antiviral drugs Cell surface Cells, Cultured Chlorocebus aethiops clinical trial Clinical trials Cloning combination therapy Coronaviruses COVID-19 COVID-19 Drug Treatment Cytotoxicity Disease transmission Drug dosages Drug Synergism EMBO23 Enzymes FDA approval HIV Homeostasis Human immunodeficiency virus Humans Infections Kidneys Life cycles Liver Models, Molecular Mortality Mutagenesis Mutation Organoids Patients Recombinant Proteins - pharmacology Ribonucleic acid RNA RNA polymerase SARS-CoV-2 - drug effects SARS-CoV-2 - physiology Severe acute respiratory syndrome coronavirus 2 Spheroids Toxicity treatment Vero Cells Virus Internalization - drug effects Virus Replication - drug effects Viruses clinical trial treatment combination therapy COVID‐19 COVID-19
ISSN:	1757-4676, 1757-4684, 1757-4684
Online-Zugang:	Volltext
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