Sequence signatures and mRNA concentration can explain two‐thirds of protein abundance variation in a human cell line

Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global contributions to steady‐state protein concentrations in multi‐cellular eukaryotes are largely unknown. Using measurements of absolute protein and mRNA a...

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Veröffentlicht in:	Molecular systems biology Jg. 6; H. 1; S. 400 - n/a
Hauptverfasser:	Vogel, Christine, de Sousa Abreu, Raquel, Ko, Daijin, Le, Shu‐Yun, Shapiro, Bruce A, Burns, Suzanne C, Sandhu, Devraj, Boutz, Daniel R, Marcotte, Edward M, Penalva, Luiz O
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 24.08.2010 John Wiley & Sons, Ltd EMBO Press Nature Publishing Group Springer Nature
Schlagworte:	5' Untranslated Regions Abundance Adaptation Amino acid sequence Bacteria Biodegradation Biotechnology Cancer Cell Line, Tumor Databases, Protein Datasets Degradation Efficiency EMBO09 EMBO10 Eukaryotes Gene expression Gene Expression Profiling Gene Expression Regulation Gene regulation Humans Medical research Medulloblastoma mRNA turnover Open reading frames Principal components analysis protein degradation protein stability Proteins Proteins - analysis Proteins - genetics Proteins - metabolism RNA, Messenger - analysis RNA, Messenger - genetics RNA, Messenger - metabolism Sousa Transcription Translation Variation gene expression regulation translation protein stability protein degradation
ISSN:	1744-4292, 1744-4292
Online-Zugang:	Volltext
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