Polygenic risk-tailored screening for prostate cancer: A benefit–harm and cost-effectiveness modelling study

The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of screening vary by an individual's risk of developing prostate cancer could inform decis...

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Bibliographic Details
Published in:	PLoS medicine Vol. 16; no. 12; p. e1002998
Main Authors:	Callender, Tom, Emberton, Mark, Morris, Steve, Eeles, Ros, Kote-Jarai, Zsofia, Pharoah, Paul D. P., Pashayan, Nora
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 20.12.2019 Public Library of Science (PLoS)
Subjects:	Age Aged Antigens Cancer research Cancer screening Comparative analysis Computer simulation Cost analysis Cost-Benefit Analysis Decision making Early Detection of Cancer - methods Economic aspects England Epidemiology Fatalities Genetic aspects Health aspects Health care costs Health risks Humans Incidence Life Tables Male Mass Screening - methods Mathematical models Medical economics Medical research Medical tests Medicine and Health Sciences Mental task performance Middle Aged Mortality Parameter uncertainty Population Population studies Prevention Preventive medicine Prostate cancer Prostate-specific antigen Prostate-Specific Antigen - analysis Prostatic Neoplasms - diagnosis Prostatic Neoplasms - epidemiology Quality-Adjusted Life Years Retirement benefits Risk Assessment Sensitivity analysis Social Sciences Software Task forces Thresholds Tradeoffs United Kingdom England United Kingdom United Kingdom > UK
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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