p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease

In Alzheimer’s disease (AD), neurodegenerative signals such as amyloid-beta (Aβ) and the precursors of neurotrophins, outbalance neurotrophic signals, causing synaptic dysfunction and neurodegeneration. The neurotrophin receptor p75 (p75NTR) is a receptor of Aβ and mediates Aβ-induced neurodegenerat...

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Vydáno v:	Molecular psychiatry Ročník 20; číslo 11; s. 1301 - 1310
Hlavní autoři:	Yao, X-Q, Jiao, S-S, Saadipour, K, Zeng, F, Wang, Q-H, Zhu, C, Shen, L-L, Zeng, G-H, Liang, C-R, Wang, J, Liu, Y-H, Hou, H-Y, Xu, X, Su, Y-P, Fan, X-T, Xiao, H-L, Lue, L-F, Zeng, Y-Q, Giunta, B, Zhong, J-H, Walker, D G, Zhou, H-D, Tan, J, Zhou, X-F, Wang, Y-J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.11.2015 Nature Publishing Group
Témata:	13/1 13/2 14/19 42/44 631/378 82/29 82/51 82/80 ADAM Proteins - metabolism ADAM17 Protein Age Factors Alzheimer Disease - complications Alzheimer Disease - drug therapy Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - toxicity Amyloid beta-protein Amyloid beta-Protein Precursor - genetics Animals Apoptosis Apoptosis - physiology Behavioral Sciences Biological Psychology Brain - drug effects Brain - metabolism Brain - pathology Brain research Case-Control Studies Cognition Disorders - etiology Cognition Disorders - therapy Disease Models, Animal Down-Regulation - genetics Enzymes Genetic aspects Hospitals Humans Maze Learning - drug effects Maze Learning - physiology Medical research Medicine Medicine & Public Health Mice Mice, Transgenic Mutation - genetics Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurodegeneration Neurosciences Neurotrophic functions Original original-article Pharmacotherapy Phosphorylation Physiological aspects Physiology Presenilin-1 - genetics Preventive medicine Protein Structure, Tertiary - physiology Psychiatry Receptors, Nerve Growth Factor - chemistry Receptors, Nerve Growth Factor - deficiency Receptors, Nerve Growth Factor - genetics Recombinant Proteins - therapeutic use Research centers Risk factors Toxicity Transduction, Genetic Tumor necrosis factor-TNF Variance analysis Australia China United States > US
ISSN:	1359-4184, 1476-5578, 1476-5578
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