Replication fork stability confers chemoresistance in BRCA-deficient cells

Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 co...

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Vydané v:	Nature (London) Ročník 535; číslo 7612; s. 382 - 387
Hlavní autori:	Ray Chaudhuri, Arnab, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., Ruiter, Julian R. de, Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 21.07.2016 Nature Publishing Group
Predmet:	631/337/1427 631/337/151/2356 631/67/1059/2326 631/67/68 Adenosine diphosphate Animals B cells Breast cancer Cancer Carrier Proteins - genetics Cell Line, Tumor Chemotherapy Cisplatin - pharmacology Deoxyribonucleic acid DNA DNA - biosynthesis DNA - metabolism DNA Breaks, Double-Stranded DNA damage DNA Damage - drug effects DNA Damage - genetics DNA Helicases - genetics DNA Repair - drug effects DNA Repair - genetics DNA Repair Enzymes - antagonists & inhibitors DNA Repair Enzymes - metabolism DNA Replication - drug effects DNA Replication - physiology DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Drug resistance Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Female Gene Deletion Genes, BRCA1 Genes, BRCA2 Homologous Recombination Humanities and Social Sciences Lymphocytes Mice MRE11 Homologue Protein multidisciplinary Neoplasms - genetics Neoplasms - pathology Nuclear Proteins - deficiency Nuclear Proteins - genetics Physiological aspects Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - genetics Proteins Replication fork Science Stem cells Tumors
ISSN:	0028-0836, 1476-4687
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