A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

Fatty acid transport from blood vessels to skeletal muscle, across endothelial cells, is regulated by the branched chain amino acid metabolite 3-hydroxy-isobutyrate. This finding provides a mechanistic explanation for the link between high levels of branched chain amino acids and diabetes. Epidemiol...

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Bibliographic Details
Published in:	Nature medicine Vol. 22; no. 4; pp. 421 - 426
Main Authors:	Jang, Cholsoon, Oh, Sungwhan F, Wada, Shogo, Rowe, Glenn C, Liu, Laura, Chan, Mun Chun, Rhee, James, Hoshino, Atsushi, Kim, Boa, Ibrahim, Ayon, Baca, Luisa G, Kim, Esl, Ghosh, Chandra C, Parikh, Samir M, Jiang, Aihua, Chu, Qingwei, Forman, Daniel E, Lecker, Stewart H, Krishnaiah, Saikumari, Rabinowitz, Joshua D, Weljie, Aalim M, Baur, Joseph A, Kasper, Dennis L, Arany, Zoltan
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2016 Nature Publishing Group
Subjects:	13/1 13/106 13/109 13/44 13/51 13/89 14/19 14/34 14/5 38/39 59 59/5 631/337 631/80/304 64 64/60 692/163/2743/137/773 82 Accumulation Amino acids Amino Acids, Branched-Chain - metabolism Animals Biological transport Biomedicine Cancer Research Development and progression Diabetes Experimental data Fatty acids Fatty Acids - genetics Fatty Acids - metabolism Fluctuations Genetic aspects Health aspects Humans Hydroxybutyrates - metabolism Infectious Diseases Insulin - genetics Insulin - metabolism Insulin resistance Insulin Resistance - genetics letter Lipids Metabolic Diseases Metabolites Mice Mice, Inbred NOD Molecular Medicine Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Neurosciences Obesity - genetics Obesity - metabolism Obesity - pathology Pathogenesis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Properties Transcription factors Transcription Factors - biosynthesis Transcription Factors - genetics
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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