Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

CMTM6 and CMTM4 bind to and stabilize the inhibitory receptor PD-L1 and regulate PD-L1 levels at the surface of human tumour and immune cells. Regulating immunity evasion PD-1/PD-L1 blocking antibodies are effective in the treatment of various cancers. In this study, Ton Schumacher and colleagues de...

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Veröffentlicht in:	Nature (London) Jg. 549; H. 7670; S. 106 - 110
Hauptverfasser:	Mezzadra, Riccardo, Sun, Chong, Jae, Lucas T., Gomez-Eerland, Raquel, de Vries, Evert, Wu, Wei, Logtenberg, Meike E. W., Slagter, Maarten, Rozeman, Elisa A., Hofland, Ingrid, Broeks, Annegien, Horlings, Hugo M., Wessels, Lodewyk F. A., Blank, Christian U., Xiao, Yanling, Heck, Albert J. R., Borst, Jannie, Brummelkamp, Thijn R., Schumacher, Ton N. M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 07.09.2017 Nature Publishing Group
Schlagworte:	13/1 13/106 13/109 13/21 13/31 13/44 13/51 13/89 38/47 38/70 38/77 38/89 631/208/200 631/250/251/1574 B7-H1 Antigen - biosynthesis B7-H1 Antigen - chemistry B7-H1 Antigen - metabolism Cancer cells Cancer metastasis Cell Line, Tumor Cell surface CRISPR-Cas Systems Dendritic cells Dendritic Cells - metabolism Genetic Complementation Test Genetic screening Haploidy Humanities and Social Sciences Humans L1 protein letter Lymphocytes Lymphocytes T MARVEL Domain-Containing Proteins - genetics MARVEL Domain-Containing Proteins - metabolism Mass spectrometry Medical research Melanoma Melanoma - genetics Melanoma - metabolism Metastases multidisciplinary PD-1 protein PD-L1 protein Physiological aspects Protein Binding Protein Stability Proteins Science Scientific imaging T cells Thyroid cancer Transcription Tumors Ubiquitination
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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