The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial

Patients with heart failure and preserved ejection fraction (HFpEF) have a high burden of symptoms and functional limitations, and have a poor quality of life. By targeting cardiometabolic abmormalities, sodium glucose cotransporter 2 (SGLT2) inhibitors may improve these impairments. In this multice...

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Bibliographic Details
Published in:	Nature medicine Vol. 27; no. 11; pp. 1954 - 1960
Main Authors:	Nassif, Michael E., Windsor, Sheryl L., Borlaug, Barry A., Kitzman, Dalane W., Shah, Sanjiv J., Tang, Fengming, Khariton, Yevgeniy, Malik, Ali O., Khumri, Taiyeb, Umpierrez, Guillermo, Lamba, Sumant, Sharma, Kavita, Khan, Sadiya S., Chandra, Lokesh, Gordon, Robert A., Ryan, John J., Chaudhry, Sunit-Preet, Joseph, Susan M., Chow, Chen H., Kanwar, Manreet K., Pursley, Michael, Siraj, Elias S., Lewis, Gregory D., Clemson, Barry S., Fong, Michael, Kosiborod, Mikhail N.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.11.2021 Nature Publishing Group
Subjects:	692/308/409 692/699/75/230 Adverse events Aged Antidiabetics Benzhydryl Compounds - adverse effects Benzhydryl Compounds - therapeutic use Biomedical and Life Sciences Biomedicine Blood pressure Cancer Research Cardiac output Cardiac patients Cardiomyopathy Care and treatment Confidence intervals Congestive heart failure Dapagliflozin Diagnosis Double-Blind Method Ejection fraction Exercise - physiology Female Glucosides - adverse effects Glucosides - therapeutic use Health Status Heart failure Heart Failure - drug therapy Hemoglobin Humans Infectious Diseases Inhibitors Male Measurement Metabolic Diseases Middle Aged Molecular Medicine Neurosciences Patients Peptides Placebos Placebos - administration & dosage Quality of life Quality of Life - psychology Risk factors Sodium-glucose cotransporter Sodium-Glucose Transporter 2 - drug effects Sodium-Glucose Transporter 2 - metabolism Sodium-Glucose Transporter 2 Inhibitors - adverse effects Sodium-Glucose Transporter 2 Inhibitors - therapeutic use Stroke Volume - drug effects Surveys and Questionnaires Testing Weight reduction United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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