Surface-enhanced Raman scattering in cancer detection and imaging

► Assays to quantify cancer biomarkers with high sensitivity and low sample volumes. ► Imaging of cancer cells, tissues, and small animals with multiplexed capabilities. ► Multimodal SERS probes and their potential for clinical translation. Technologies that use surface-enhanced Raman scattering (SE...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) Vol. 31; no. 4; pp. 249 - 257
Main Authors: Vendrell, Marc, Maiti, Kaustabh Kumar, Dhaliwal, Kevin, Chang, Young-Tae
Format: Journal Article
Language:English
Published: Cambridge, MA Elsevier Ltd 01.04.2013
Cell Press
Elsevier Limited
Subjects:
Animals
Antigens
Biological and medical sciences
Biomarkers
biomedical research
biopsy
Biotechnology
Breast cancer
Deoxyribonucleic acid
Diagnostic Imaging - methods
diagnostic techniques
diagnostics
DNA
drugs
Fundamental and applied biological sciences. Psychology
Humans
image analysis
Immunoassay
Internal Medicine
Mice
microscopy
molecular imaging
nanoparticles
nanotechnology
neoplasm cells
neoplasms
Neoplasms - diagnosis
oncology
Plasma
Prostate cancer
Raman spectroscopy
single nucleotide polymorphism
Spectrum Analysis, Raman - methods
translational research
nanotechnology
diagnostics
translational research
nanoparticles
molecular imaging
oncology
Surface enhanced scattering
Malignant tumor
Detection
Imagery
Cancer
ISSN:0167-7799, 1879-3096, 1879-3096
Online Access:Get full text
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Summary:► Assays to quantify cancer biomarkers with high sensitivity and low sample volumes. ► Imaging of cancer cells, tissues, and small animals with multiplexed capabilities. ► Multimodal SERS probes and their potential for clinical translation. Technologies that use surface-enhanced Raman scattering (SERS) have experienced significant growth in biomedical research during the past 4 years. In this review we summarize the progress in SERS for cancer diagnostics, including multiplexed detection and identification of new biomarkers, single-nucleotide polymorphisms, and circulating tumor cells. SERS is also used as a non-invasive tool for cancer imaging with immunoSERS microscopy, histological analysis of biopsies, and in vivo detection of tumors. We discuss the future of SERS probes compatible with multiple imaging modalities and their potential for clinical translation (e.g., endoscope-based and intraoperative imaging as tools for surgical guidance). Moreover, we highlight the potential of SERS agents for targeted drug delivery and photothermal therapy.
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ISSN:0167-7799
1879-3096
1879-3096
DOI:10.1016/j.tibtech.2013.01.013