Detection of immunogenic cell death and its relevance for cancer therapy

Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompa...

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Vydáno v:	Cell death & disease Ročník 11; číslo 11; s. 1013 - 13
Hlavní autoři:	Fucikova, Jitka, Kepp, Oliver, Kasikova, Lenka, Petroni, Giulia, Yamazaki, Takahiro, Liu, Peng, Zhao, Liwei, Spisek, Radek, Kroemer, Guido, Galluzzi, Lorenzo
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 26.11.2020 Springer Nature B.V Nature Publishing Group
Témata:	631/154 631/250/1932 631/67/1059/2325 Adjuvanticity Antibodies Antigen-presenting cells Antigenicity Antineoplastic drugs Antitumor agents Apoptosis Autophagy Biochemistry Biomedical and Life Sciences Calreticulin Cancer Cancer therapies Cell activation Cell Biology Cell Culture Cell death Chemotherapy Drug Discovery - methods HMGB1 protein Humans Immune response Immunogenic Cell Death - immunology Immunogenicity Immunology Immunotherapy - methods Initiation factor eIF-2 Interferon Life Sciences Neoplasms - therapy Phagocytosis Phosphorylation Radiation therapy Review Review Article Transcription
ISSN:	2041-4889, 2041-4889
On-line přístup:	Získat plný text
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Shrnutí:	Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically relevant tumor-targeting immune responses, which critically rely on the antigenicity of malignant cells and their capacity to generate adjuvant signals. In particular, immunogenic cell death (ICD) is accompanied by the exposure and release of numerous damage-associated molecular patterns (DAMPs), which altogether confer a robust adjuvanticity to dying cancer cells, as they favor the recruitment and activation of antigen-presenting cells. ICD-associated DAMPs include surface-exposed calreticulin (CALR) as well as secreted ATP, annexin A1 (ANXA1), type I interferon, and high-mobility group box 1 (HMGB1). Additional hallmarks of ICD encompass the phosphorylation of eukaryotic translation initiation factor 2 subunit-α (EIF2S1, better known as eIF2α), the activation of autophagy, and a global arrest in transcription and translation. Here, we outline methodological approaches for measuring ICD markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 PMCID: PMC7691519
ISSN:	2041-4889 2041-4889
DOI:	10.1038/s41419-020-03221-2