A Photoactivatable AIE Polymer for Light-Controlled Gene Delivery: Concurrent Endo/Lysosomal Escape and DNA Unpacking

Endo/lysosomal escape of gene vectors and the subsequent unpacking of nucleic acids in cytosol are two major challenges for efficient gene delivery. Herein, we report a polymeric gene delivery vector, which consists of a photosensitizer (PS) with aggregation‐induced emission (AIE) characteristics an...

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Veröffentlicht in:	Angewandte Chemie International Edition Jg. 54; H. 39; S. 11419 - 11423
Hauptverfasser:	Yuan, Youyong, Zhang, Chong-Jing, Liu, Bin
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Weinheim WILEY-VCH Verlag 21.09.2015 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Ausgabe:	International ed. in English
Schlagworte:	aggregation-induced emission Aqueous solutions Cytosol Deoxyribonucleic acid DNA DNA - chemistry Electrostatic properties Emission endo/lysosomes Endosomes - metabolism Fluorescence gene delivery Gene transfer Gene Transfer Techniques Genes HeLa Cells Humans Irradiation Light Light irradiation Lysosomes Lysosomes - metabolism Mathematical analysis Nanoparticles Nucleic acids Photochemical Processes Polymers Polymers - chemistry Radiation Reactive oxygen species Reactive Oxygen Species - metabolism Static Electricity Vectors (mathematics) gene delivery aggregation-induced emission endo/lysosomes polymers reactive oxygen species
ISSN:	1433-7851, 1521-3773, 1521-3773
Online-Zugang:	Volltext
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