The glymphatic system: Current understanding and modeling

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, str...

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Veröffentlicht in:iScience Jg. 25; H. 9; S. 104987
Hauptverfasser: Bohr, Tomas, Hjorth, Poul G., Holst, Sebastian C., Hrabětová, Sabina, Kiviniemi, Vesa, Lilius, Tuomas, Lundgaard, Iben, Mardal, Kent-Andre, Martens, Erik A., Mori, Yuki, Nägerl, U. Valentin, Nicholson, Charles, Tannenbaum, Allen, Thomas, John H., Tithof, Jeffrey, Benveniste, Helene, Iliff, Jeffrey J., Kelley, Douglas H., Nedergaard, Maiken
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Elsevier Inc 16.09.2022
Elsevier
Schlagworte:
Basic Medicine
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Neuroanatomy
Neuroscience
Neurosciences
Neurovetenskaper
Review
Systems biology
Systems biology
Neuroscience
Neuroanatomy
ISSN:2589-0042, 2589-0042
Online-Zugang:Volltext
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Abstract We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer’s disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field. [Display omitted] Neuroscience; Neuroanatomy; Systems biology
AbstractList We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer’s disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer’s disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field. [Display omitted] Neuroscience; Neuroanatomy; Systems biology
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer's disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field.
We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer’s disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field. Neuroscience; Neuroanatomy; Systems biology
ArticleNumber 104987
Author Martens, Erik A.
Mardal, Kent-Andre
Lilius, Tuomas
Benveniste, Helene
Nicholson, Charles
Nägerl, U. Valentin
Hjorth, Poul G.
Kiviniemi, Vesa
Iliff, Jeffrey J.
Holst, Sebastian C.
Lundgaard, Iben
Hrabětová, Sabina
Bohr, Tomas
Nedergaard, Maiken
Tithof, Jeffrey
Kelley, Douglas H.
Mori, Yuki
Tannenbaum, Allen
Thomas, John H.
Author_xml – sequence: 1
  givenname: Tomas
  surname: Bohr
  fullname: Bohr, Tomas
  organization: Department of Physics, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
– sequence: 2
  givenname: Poul G.
  surname: Hjorth
  fullname: Hjorth, Poul G.
  organization: Department of Applied Mathematics and Computer Science, Technical University of Denmark, Richard Petersens Plads, 2800 Kgs. Lyngby, Denmark
– sequence: 3
  givenname: Sebastian C.
  surname: Holst
  fullname: Holst, Sebastian C.
  organization: Neuroscience and Rare Diseases Discovery and Translational Area, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070 Basel, Switzerland
– sequence: 4
  givenname: Sabina
  surname: Hrabětová
  fullname: Hrabětová, Sabina
  organization: Department of Cell Biology and The Robert Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, NY, USA
– sequence: 5
  givenname: Vesa
  surname: Kiviniemi
  fullname: Kiviniemi, Vesa
  organization: Oulu Functional NeuroImaging, Department of Diagnostic Radiology, MRC, Oulu University Hospital, Oulu, Finland
– sequence: 6
  givenname: Tuomas
  surname: Lilius
  fullname: Lilius, Tuomas
  organization: Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
– sequence: 7
  givenname: Iben
  surname: Lundgaard
  fullname: Lundgaard, Iben
  organization: Department of Experimental Medical Science, Lund University, Lund, Sweden
– sequence: 8
  givenname: Kent-Andre
  surname: Mardal
  fullname: Mardal, Kent-Andre
  organization: Department of Mathematics, University of Oslo, Oslo, Norway
– sequence: 9
  givenname: Erik A.
  surname: Martens
  fullname: Martens, Erik A.
  organization: Centre for Mathematical Sciences, Lund University, Sweden
– sequence: 10
  givenname: Yuki
  surname: Mori
  fullname: Mori, Yuki
  organization: Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
– sequence: 11
  givenname: U. Valentin
  surname: Nägerl
  fullname: Nägerl, U. Valentin
  organization: Instítut Interdisciplinaire de Neurosciences, Université de Bordeaux / CNRS UMR 5297, Centre Broca Nouvelle-Aquitaine, 146 rue Léo Saignat, CS 61292 Case 130, 33076 Bordeaux Cedex France
– sequence: 12
  givenname: Charles
  surname: Nicholson
  fullname: Nicholson, Charles
  organization: Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, NY, USA
– sequence: 13
  givenname: Allen
  surname: Tannenbaum
  fullname: Tannenbaum, Allen
  organization: Departments of Computer Science/ Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, USA
– sequence: 14
  givenname: John H.
  surname: Thomas
  fullname: Thomas, John H.
  organization: Department of Mechanical Engineering, University of Rochester, Rochester, 14627 NY, USA
– sequence: 15
  givenname: Jeffrey
  surname: Tithof
  fullname: Tithof, Jeffrey
  organization: Department of Mechanical Engineering, University of Minnesota, Minneapolis, USA
– sequence: 16
  givenname: Helene
  surname: Benveniste
  fullname: Benveniste, Helene
  organization: Department of Anesthesiology, Yale School of Medicine, New Haven, CT, USA
– sequence: 17
  givenname: Jeffrey J.
  surname: Iliff
  fullname: Iliff, Jeffrey J.
  organization: VISN 20 Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA, USA
– sequence: 18
  givenname: Douglas H.
  surname: Kelley
  fullname: Kelley, Douglas H.
  email: d.h.kelley@rochester.edu
  organization: Department of Mechanical Engineering, University of Rochester, Rochester, 14627 NY, USA
– sequence: 19
  givenname: Maiken
  surname: Nedergaard
  fullname: Nedergaard, Maiken
  email: maiken_nedergaard@urmc.rochester.edu
  organization: Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36093063$$D View this record in MEDLINE/PubMed
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Snippet We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating...
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SubjectTerms Basic Medicine
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Neuroanatomy
Neuroscience
Neurosciences
Neurovetenskaper
Review
Systems biology
Title The glymphatic system: Current understanding and modeling
URI https://dx.doi.org/10.1016/j.isci.2022.104987
https://www.ncbi.nlm.nih.gov/pubmed/36093063
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