The glymphatic system: Current understanding and modeling

We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, str...

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Bibliographic Details
Published in:iScience Vol. 25; no. 9; p. 104987
Main Authors: Bohr, Tomas, Hjorth, Poul G., Holst, Sebastian C., Hrabětová, Sabina, Kiviniemi, Vesa, Lilius, Tuomas, Lundgaard, Iben, Mardal, Kent-Andre, Martens, Erik A., Mori, Yuki, Nägerl, U. Valentin, Nicholson, Charles, Tannenbaum, Allen, Thomas, John H., Tithof, Jeffrey, Benveniste, Helene, Iliff, Jeffrey J., Kelley, Douglas H., Nedergaard, Maiken
Format: Journal Article
Language:English
Published: United States Elsevier Inc 16.09.2022
Elsevier
Subjects:
Basic Medicine
Medical and Health Sciences
Medicin och hälsovetenskap
Medicinska och farmaceutiska grundvetenskaper
Neuroanatomy
Neuroscience
Neurosciences
Neurovetenskaper
Review
Systems biology
Systems biology
Neuroscience
Neuroanatomy
ISSN:2589-0042, 2589-0042
Online Access:Get full text
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Summary:We review theoretical and numerical models of the glymphatic system, which circulates cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models enable hypothesis development and predictions of transport, with clinical applications including drug delivery, stroke, cardiac arrest, and neurodegenerative disorders like Alzheimer’s disease. We sort existing models into broad categories by anatomical function: Perivascular flow, transport in brain parenchyma, interfaces to perivascular spaces, efflux routes, and links to neuronal activity. Needs and opportunities for future work are highlighted wherever possible; new models, expanded models, and novel experiments to inform models could all have tremendous value for advancing the field. [Display omitted] Neuroscience; Neuroanatomy; Systems biology
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ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2022.104987