Reprogramming of murine and human somatic cells using a single polycistronic vector

Directed reprogramming of somatic cells by defined factors provides a novel method for the generation of patient-specific stem cells with the potential to bypass both the practical and ethical concerns associated with somatic cell nuclear transfer (SCNT) and human embryonic stem (hES) cells. Althoug...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 106; číslo 1; s. 157
Hlavní autoři:	Carey, Bryce W, Markoulaki, Styliani, Hanna, Jacob, Saha, Kris, Gao, Qing, Mitalipova, Maisam, Jaenisch, Rudolf
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.01.2009
Témata:	Animals Cells Cells, Cultured Cellular Reprogramming - genetics Fibroblasts - cytology Genetic Vectors - genetics Keratinocytes - cytology Kruppel-Like Transcription Factors - genetics Mice Octamer Transcription Factor-3 - genetics Pluripotent Stem Cells - cytology Proto-Oncogene Proteins c-myc - genetics SOXB1 Transcription Factors - genetics Transfection - methods Transgenes - genetics
ISSN:	1091-6490, 1091-6490
On-line přístup:	Zjistit podrobnosti o přístupu
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