Nuclear reprogramming to a pluripotent state by three approaches

The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three di...

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Veröffentlicht in:	Nature (London) Jg. 465; H. 7299; S. 704 - 712
Hauptverfasser:	Yamanaka, Shinya, Blau, Helen M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 10.06.2010 Nature Publishing Group
Schlagworte:	631/136/2444 631/136/532/2064 631/136/532/2435 631/1647/1513 Amphibians - embryology Animals Cell Fusion Cellular Reprogramming - genetics Cellular Reprogramming - physiology Deoxyribonucleic acid DNA DNA methylation Embryonic development Embryonic stem cells Gene expression Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mammals multidisciplinary Nuclear Transfer Techniques review-article Science Science (multidisciplinary) Stem cells Studies Transcription Factors - genetics Transcription Factors - metabolism Transduction, Genetic
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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