Nuclear reprogramming to a pluripotent state by three approaches

The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three di...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Nature (London) Ročník 465; číslo 7299; s. 704 - 712
Hlavní autori:	Yamanaka, Shinya, Blau, Helen M.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 10.06.2010 Nature Publishing Group
Predmet:	631/136/2444 631/136/532/2064 631/136/532/2435 631/1647/1513 Amphibians - embryology Animals Cell Fusion Cellular Reprogramming - genetics Cellular Reprogramming - physiology Deoxyribonucleic acid DNA DNA methylation Embryonic development Embryonic stem cells Gene expression Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mammals multidisciplinary Nuclear Transfer Techniques review-article Science Science (multidisciplinary) Stem cells Studies Transcription Factors - genetics Transcription Factors - metabolism Transduction, Genetic
ISSN:	0028-0836, 1476-4687, 1476-4687
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three distinct experimental approaches to nuclear reprogramming: nuclear transfer, cell fusion and transcription-factor transduction. Using these approaches, nuclei from 'terminally differentiated' somatic cells can be induced to express genes that are typical of embryonic stem cells, which can differentiate to form all of the cell types in the body. This remarkable discovery of cellular plasticity has important medical applications.
AbstractList	The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three distinct experimental approaches to nuclear reprogramming: nuclear transfer, cell fusion and transcription-factor transduction. Using these approaches, nuclei from 'terminally differentiated' somatic cells can be induced to express genes that are typical of embryonic stem cells, which can differentiate to form all of the cell types in the body. This remarkable discovery of cellular plasticity has important medical applications.The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three distinct experimental approaches to nuclear reprogramming: nuclear transfer, cell fusion and transcription-factor transduction. Using these approaches, nuclei from 'terminally differentiated' somatic cells can be induced to express genes that are typical of embryonic stem cells, which can differentiate to form all of the cell types in the body. This remarkable discovery of cellular plasticity has important medical applications. The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three distinct experimental approaches to nuclear reprogramming: nuclear transfer, cell fusion and transcription-factor transduction. Using these approaches, nuclei from 'terminally differentiated' somatic cells can be induced to express genes that are typical of embryonic stem cells, which can differentiate to form all of the cell types in the body. This remarkable discovery of cellular plasticity has important medical applications. The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be reprogrammed, altering its pattern of gene expression, and hence its fate, to that typical of another cell type. This has been shown by three distinct experimental approaches to nuclear reprogramming: nuclear transfer, cell fusion and transcription-factor transduction. Using these approaches, nuclei from 'terminally differentiated' somatic cells can be induced to express genes that are typical of embryonic stem cells, which can differentiate to form all of the cell types in the body. This remarkable discovery of cellular plasticity has important medical applications. [PUBLICATION ABSTRACT]
Audience	Academic
Author	Yamanaka, Shinya Blau, Helen M.
AuthorAffiliation	2 Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA 1 Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan 3 Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California 94305, USA
AuthorAffiliation_xml	– name: 3 Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, California 94305, USA – name: 1 Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan – name: 2 Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
Author_xml	– sequence: 1 givenname: Shinya surname: Yamanaka fullname: Yamanaka, Shinya organization: Center for iPS Cell Research and Application, Kyoto University, Gladstone Institute of Cardiovascular Disease – sequence: 2 givenname: Helen M. surname: Blau fullname: Blau, Helen M. email: hblau2@stanford.edu organization: Department of Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20535199$$D View this record in MEDLINE/PubMed
BookMark	eNpt0t9r1TAUB_AgE_dDn3yXMh9EtDNJ07R5Ecfwx2Ao-OM55KYnvRlt0iWpuP_eXO6m946Sh0L7Od-kJ-cYHTjvAKHnBJ8RXLXvnEpzACwoFY_QEWENLxlvmwN0hDFtS9xW_BAdx3iNMa5Jw56gQ4rrqiZCHKEPX2c9gApFgCn4PqhxtK4vki9UMQ1zsJNP4FIRk0pQrG6LtA4AhZqyVnoN8Sl6bNQQ4dnd8wT9-vTx58WX8urb58uL86tS84an0mjTAKu7zjBmuFIgOs4r1ilCtcJQAdVG02ZFO-DAeCMaIjCuKoaZIbg21Ql6v82d5tUInc6HCmqQU7CjCrfSKyv3vzi7lr3_LanAhNQsB7y6Cwj-ZoaY5GijhmFQDvwcZVNVlBMuqixPH8hrPweX_07WpCX1ZmX0cot6NYC0zvi8q95EyvN8E5i3VIisygXVg4N8xHyNxubXe_50wevJ3shddLaA8upgtHox9fVeQTYJ_qRezTHKyx_f9-2L3T7_a_D9yGRAtkAHH2MAI7XNw2H9pu12kATLzVjKnbHMNW8e1NzHLuu3Wx2zcj2E__1f4n8Bvy3w9g
CODEN	NATUAS
CitedBy_id	crossref_primary_10_1016_j_trim_2023_101903 crossref_primary_10_1056_NEJMra1716145 crossref_primary_10_1016_j_neuroscience_2012_09_076 crossref_primary_10_1038_nmeth_1549 crossref_primary_10_1096_fj_12_222125 crossref_primary_10_1371_journal_pgen_1003112 crossref_primary_10_5966_sctm_2013_0127 crossref_primary_10_1007_s00232_012_9470_2 crossref_primary_10_1093_abbs_gmr099 crossref_primary_10_1016_j_tig_2015_11_001 crossref_primary_10_2174_0122117385300234240522100826 crossref_primary_10_1161_CIRCRESAHA_116_302832 crossref_primary_10_1093_hmg_ddq404 crossref_primary_10_1038_ncb2366 crossref_primary_10_1177_03008916231158411 crossref_primary_10_1007_s40495_016_0054_1 crossref_primary_10_1371_journal_pone_0033945 crossref_primary_10_1093_eurheartj_ehw341 crossref_primary_10_1371_journal_pone_0032612 crossref_primary_10_1016_j_yexcr_2013_12_013 crossref_primary_10_1016_j_diff_2012_02_003 crossref_primary_10_1016_j_bbagen_2014_02_004 crossref_primary_10_1016_j_radonc_2016_01_025 crossref_primary_10_1057_s41292_016_0027_y crossref_primary_10_1089_scd_2013_0576 crossref_primary_10_3389_fbioe_2017_00034 crossref_primary_10_1139_gen_2020_0135 crossref_primary_10_1371_journal_pone_0019743 crossref_primary_10_5966_sctm_2013_0111 crossref_primary_10_1089_cell_2015_0039 crossref_primary_10_1016_j_drudis_2011_04_007 crossref_primary_10_1016_j_dnarep_2016_05_013 crossref_primary_10_3389_fimmu_2019_02809 crossref_primary_10_1113_JP270874 crossref_primary_10_1016_j_it_2014_02_003 crossref_primary_10_1038_s43587_025_00857_7 crossref_primary_10_1016_S2095_3119_14_60882_0 crossref_primary_10_1038_nrcardio_2010_159 crossref_primary_10_1002_stem_1121 crossref_primary_10_1530_REP_10_0394 crossref_primary_10_1089_scd_2010_0385 crossref_primary_10_1089_cell_2015_0001 crossref_primary_10_1161_CIRCRESAHA_114_305567 crossref_primary_10_1371_journal_pone_0021801 crossref_primary_10_1155_2014_740926 crossref_primary_10_1017_S146114571300117X crossref_primary_10_1016_j_biomaterials_2014_04_074 crossref_primary_10_1016_j_cell_2011_01_032 crossref_primary_10_1038_s41563_020_00829_9 crossref_primary_10_1038_gt_2011_38 crossref_primary_10_1186_1471_2202_15_95 crossref_primary_10_1007_s12015_012_9348_9 crossref_primary_10_1016_j_theriogenology_2016_04_022 crossref_primary_10_4065_mcp_2011_0054 crossref_primary_10_1038_s41388_018_0370_5 crossref_primary_10_1038_nsmb_2510 crossref_primary_10_1073_pnas_1219124110 crossref_primary_10_1038_nchembio_477 crossref_primary_10_1186_scrt73 crossref_primary_10_1016_j_cub_2010_06_027 crossref_primary_10_1371_journal_pone_0076422 crossref_primary_10_1007_s12033_013_9702_4 crossref_primary_10_1007_s42764_021_00058_7 crossref_primary_10_3109_10409238_2012_697125 crossref_primary_10_1155_2016_8415010 crossref_primary_10_1002_cyto_a_21081 crossref_primary_10_1016_j_stem_2011_11_012 crossref_primary_10_1016_j_stem_2014_01_003 crossref_primary_10_1016_j_stem_2011_11_015 crossref_primary_10_1016_j_compbiolchem_2011_05_002 crossref_primary_10_1089_cell_2012_0043 crossref_primary_10_2174_0929867330666230503144619 crossref_primary_10_1002_stem_1307 crossref_primary_10_1016_j_ddtec_2011_04_001 crossref_primary_10_3389_fped_2016_00080 crossref_primary_10_3390_cells11203266 crossref_primary_10_1038_nrg2969 crossref_primary_10_1186_s13072_018_0244_7 crossref_primary_10_1038_cr_2011_190 crossref_primary_10_1038_s41598_018_29129_8 crossref_primary_10_3727_096368913X670958 crossref_primary_10_1089_cell_2011_0050 crossref_primary_10_1002_iub_1213 crossref_primary_10_1016_j_gde_2013_06_005 crossref_primary_10_1371_journal_pcbi_1002300 crossref_primary_10_1371_journal_pcbi_1002543 crossref_primary_10_1002_adfm_201806694 crossref_primary_10_1080_10520295_2023_2248880 crossref_primary_10_1007_s11302_011_9282_3 crossref_primary_10_1038_nrg2951 crossref_primary_10_1242_dev_091603 crossref_primary_10_5966_sctm_2013_0151 crossref_primary_10_1038_ncomms3174 crossref_primary_10_1038_467039a crossref_primary_10_1089_scd_2018_0034 crossref_primary_10_7554_eLife_03573 crossref_primary_10_1002_bies_201000090 crossref_primary_10_1016_j_bbr_2016_12_039 crossref_primary_10_3389_fnins_2014_00102 crossref_primary_10_3390_scipharm87010006 crossref_primary_10_3390_ijms160715531 crossref_primary_10_1089_cell_2011_0069 crossref_primary_10_1038_nbt1010_1033 crossref_primary_10_1016_j_stem_2010_07_005 crossref_primary_10_1111_dom_12717 crossref_primary_10_3390_ijms24010140 crossref_primary_10_1002_adma_202410908 crossref_primary_10_1161_CIRCRESAHA_111_243394 crossref_primary_10_3727_096368912X657477 crossref_primary_10_1155_2016_6180487 crossref_primary_10_1063_1_4871036 crossref_primary_10_1111_rda_12977 crossref_primary_10_3389_fimmu_2025_1640935 crossref_primary_10_1038_s41418_018_0177_5 crossref_primary_10_1074_jbc_M111_324368 crossref_primary_10_1155_2021_6241600 crossref_primary_10_1038_ncomms5697 crossref_primary_10_1002_wdev_206 crossref_primary_10_14348_molcells_2014_2212 crossref_primary_10_1089_cell_2012_0058 crossref_primary_10_1146_annurev_bioeng_071910_124733 crossref_primary_10_1186_s12885_016_2094_7 crossref_primary_10_1056_NEJMoa1101324 crossref_primary_10_1002_mrd_22531 crossref_primary_10_1016_j_bbagrm_2017_07_009 crossref_primary_10_1002_stem_1628 crossref_primary_10_1016_j_diff_2014_07_001 crossref_primary_10_1016_j_addr_2014_11_023 crossref_primary_10_1161_CIRCRESAHA_111_247213 crossref_primary_10_1016_j_mad_2018_05_009 crossref_primary_10_1038_ncomms13396 crossref_primary_10_1016_j_celrep_2023_112897 crossref_primary_10_1074_jbc_M112_391441 crossref_primary_10_1083_jcb_201611012 crossref_primary_10_1007_s12015_015_9620_x crossref_primary_10_1038_s41598_017_13916_w crossref_primary_10_1126_science_1239278 crossref_primary_10_1097_MOT_0000000000000144 crossref_primary_10_1016_j_stem_2014_09_015 crossref_primary_10_1146_annurev_biophys_042910_155319 crossref_primary_10_1002_jctb_4803 crossref_primary_10_1016_j_cbi_2019_108919 crossref_primary_10_1089_scd_2011_0150 crossref_primary_10_1161_CIRCRESAHA_113_301053 crossref_primary_10_1084_jem_20101866 crossref_primary_10_1038_nrg3209 crossref_primary_10_1016_j_gde_2020_05_016 crossref_primary_10_1186_2001_1326_2_11 crossref_primary_10_1007_s10304_012_0493_7 crossref_primary_10_1016_j_scr_2015_11_002 crossref_primary_10_1371_journal_pone_0068627 crossref_primary_10_1038_emboj_2013_132 crossref_primary_10_1016_j_actbio_2011_11_019 crossref_primary_10_1186_s13073_016_0342_8 crossref_primary_10_1038_emboj_2011_50 crossref_primary_10_1007_s00417_015_3128_6 crossref_primary_10_1016_j_yjmcc_2014_06_016 crossref_primary_10_1038_cr_2016_9 crossref_primary_10_1016_j_bbagen_2012_08_010 crossref_primary_10_1038_cr_2012_175 crossref_primary_10_1016_j_stem_2012_05_005 crossref_primary_10_7554_eLife_48767 crossref_primary_10_1007_s10616_020_00416_5 crossref_primary_10_1007_s40778_015_0018_0 crossref_primary_10_1186_s13148_021_01131_4 crossref_primary_10_1016_j_stem_2018_06_018 crossref_primary_10_1007_s11515_013_1275_x crossref_primary_10_1016_j_arr_2023_102113 crossref_primary_10_1177_1073858414547538 crossref_primary_10_1089_scd_2014_0120 crossref_primary_10_1016_j_bbagen_2012_08_025 crossref_primary_10_1002_stem_603 crossref_primary_10_1016_j_cell_2011_08_042 crossref_primary_10_17816_ACEN_2017_2_5 crossref_primary_10_3390_cancers11020185 crossref_primary_10_1038_s41423_022_00842_9 crossref_primary_10_1016_j_jbiosc_2011_07_005 crossref_primary_10_1038_aja_2011_88 crossref_primary_10_3390_v3050429 crossref_primary_10_1038_s41588_025_02303_1 crossref_primary_10_2217_rme_11_6 crossref_primary_10_3389_fimmu_2014_00229 crossref_primary_10_1557_mrs2010_527 crossref_primary_10_3390_ph4101355 crossref_primary_10_1038_s41576_021_00341_z crossref_primary_10_1016_j_bpg_2012_01_001 crossref_primary_10_1002_ajmg_a_36455 crossref_primary_10_1038_ncb2311 crossref_primary_10_1038_s41467_024_55286_8 crossref_primary_10_1038_nrc3087 crossref_primary_10_1111_gtc_12763 crossref_primary_10_1016_j_neulet_2012_02_086 crossref_primary_10_1016_j_coph_2014_02_002 crossref_primary_10_1242_dev_182170 crossref_primary_10_1134_S2079086414040069 crossref_primary_10_1016_j_biomaterials_2019_119743 crossref_primary_10_1038_nature12942 crossref_primary_10_1073_pnas_1518244113 crossref_primary_10_3390_mi13030402 crossref_primary_10_1093_mutage_gey041 crossref_primary_10_3389_fonc_2020_01657 crossref_primary_10_1016_j_ydbio_2014_04_015 crossref_primary_10_1038_s41594_020_0445_1 crossref_primary_10_1016_j_stem_2012_03_003 crossref_primary_10_1016_j_bbrc_2015_07_070 crossref_primary_10_1073_pnas_1100733108 crossref_primary_10_1038_clpt_2010_341 crossref_primary_10_3390_cancers14163871 crossref_primary_10_1016_j_mayocp_2013_04_017 crossref_primary_10_1089_scd_2011_0471 crossref_primary_10_1126_science_abl8679 crossref_primary_10_1186_1471_2164_15_978 crossref_primary_10_1016_j_drup_2012_02_001 crossref_primary_10_1016_j_biotechadv_2018_01_016 crossref_primary_10_3109_10408363_2012_742487 crossref_primary_10_1089_cell_2014_0089 crossref_primary_10_1002_stem_770 crossref_primary_10_1016_j_gde_2022_101999 crossref_primary_10_1073_pnas_1009412107 crossref_primary_10_1007_s10549_018_5023_4 crossref_primary_10_1007_s00018_012_1137_8 crossref_primary_10_1242_dev_132928 crossref_primary_10_1101_gad_1963010 crossref_primary_10_3892_mmr_2022_12886 crossref_primary_10_4061_2011_212487 crossref_primary_10_1007_s00018_012_1235_7 crossref_primary_10_1038_s41598_021_90653_1 crossref_primary_10_1002_stem_1600 crossref_primary_10_1042_BJ20101707 crossref_primary_10_2492_inflammregen_31_33 crossref_primary_10_1007_s00132_018_3630_8 crossref_primary_10_1016_j_clon_2017_03_005 crossref_primary_10_1016_j_gde_2021_07_006 crossref_primary_10_1038_s41467_023_40496_3 crossref_primary_10_3390_ijms151221840 crossref_primary_10_1002_cyto_a_24726 crossref_primary_10_1016_j_molcel_2013_01_032 crossref_primary_10_1038_nbt_1946 crossref_primary_10_4161_epi_28600 crossref_primary_10_1371_journal_pone_0131966 crossref_primary_10_1016_j_diff_2011_01_003 crossref_primary_10_1161_CIRCRESAHA_112_270637 crossref_primary_10_1007_s11517_011_0776_5 crossref_primary_10_1038_nature12749 crossref_primary_10_1002_cne_23620 crossref_primary_10_1088_1758_5090_aa7e9a crossref_primary_10_7717_peerj_10346 crossref_primary_10_1146_annurev_pathol_011110_130237 crossref_primary_10_1242_jcs_082446 crossref_primary_10_1161_CIRCRESAHA_112_271452 crossref_primary_10_4161_cc_29704 crossref_primary_10_1016_j_bpj_2012_08_062 crossref_primary_10_1161_CIRCRESAHA_111_249235 crossref_primary_10_1089_scd_2015_0359 crossref_primary_10_1186_s13000_015_0263_7 crossref_primary_10_1007_s12026_010_8190_x crossref_primary_10_1186_1471_2164_15_488 crossref_primary_10_1126_science_1190614 crossref_primary_10_1002_msj_20233 crossref_primary_10_1134_S0006297915110024 crossref_primary_10_1038_srep06996 crossref_primary_10_1016_j_mehy_2013_01_009 crossref_primary_10_1146_annurev_physiol_021113_170301 crossref_primary_10_1111_joim_12024 crossref_primary_10_1016_j_semcdb_2011_02_025 crossref_primary_10_1016_j_stem_2013_10_005 crossref_primary_10_3389_fcell_2017_00070 crossref_primary_10_1007_s12015_010_9216_4 crossref_primary_10_1038_nrm3140 crossref_primary_10_1016_j_tcb_2012_04_002 crossref_primary_10_1111_j_1749_6632_2012_06487_x crossref_primary_10_3390_ijms18030552 crossref_primary_10_1016_j_cell_2013_01_012 crossref_primary_10_1073_pnas_1019743108 crossref_primary_10_1089_cell_2017_0022 crossref_primary_10_1016_j_gde_2021_04_004 crossref_primary_10_1016_j_tcb_2010_08_003 crossref_primary_10_1016_j_molcel_2012_02_013 crossref_primary_10_1016_j_ymthe_2025_08_013 crossref_primary_10_1146_annurev_cellbio_101512_122422 crossref_primary_10_1038_mt_2015_41 crossref_primary_10_1503_jpn_230112 crossref_primary_10_4161_cc_27305 crossref_primary_10_1007_s13238_015_0180_2 crossref_primary_10_1016_j_molcel_2012_09_008 crossref_primary_10_3760_cma_j_issn_0366_6999_20122755 crossref_primary_10_1002_cbf_3892 crossref_primary_10_1007_s10529_014_1580_8 crossref_primary_10_1016_j_gde_2012_09_002 crossref_primary_10_1038_ncb2717 crossref_primary_10_3390_genes2010081 crossref_primary_10_1016_j_compbiolchem_2022_107689 crossref_primary_10_1038_ncb2835 crossref_primary_10_1093_nsr_nwv009 crossref_primary_10_1242_dev_092049 crossref_primary_10_1002_stem_684 crossref_primary_10_3389_fcimb_2024_1457323 crossref_primary_10_1016_j_theriogenology_2012_08_012 crossref_primary_10_1111_febs_12665 crossref_primary_10_1016_j_jgg_2013_04_011 crossref_primary_10_3390_ijms18030577 crossref_primary_10_1016_j_micron_2011_10_002 crossref_primary_10_1038_mi_2012_6 crossref_primary_10_1007_s12072_011_9300_0 crossref_primary_10_1016_j_cell_2010_10_008 crossref_primary_10_1186_s12885_015_1935_0 crossref_primary_10_1242_jcs_133082 crossref_primary_10_1038_nrm3043 crossref_primary_10_1002_hep_24143 crossref_primary_10_1016_j_stem_2012_01_001 crossref_primary_10_1155_2016_9464591 crossref_primary_10_1002_adma_202211609 crossref_primary_10_3390_ijms20215495 crossref_primary_10_1007_s10522_013_9455_2 crossref_primary_10_1084_jem_20121044 crossref_primary_10_1016_j_addr_2017_09_010 crossref_primary_10_1089_scd_2010_0525 crossref_primary_10_1016_j_exphem_2020_08_003 crossref_primary_10_4161_fly_23969 crossref_primary_10_1242_dev_050849 crossref_primary_10_1016_j_bbamcr_2013_03_025 crossref_primary_10_1159_000326623 crossref_primary_10_1182_blood_2010_07_298596 crossref_primary_10_1017_S1462399410001626 crossref_primary_10_1038_ng_2491 crossref_primary_10_1038_s41467_018_03008_2 crossref_primary_10_1007_s00281_011_0265_9 crossref_primary_10_1134_S036211971808011X crossref_primary_10_3389_fonc_2018_00475 crossref_primary_10_1038_s41467_022_35199_0 crossref_primary_10_1186_s13287_022_03028_2 crossref_primary_10_3390_foods10102318 crossref_primary_10_1016_j_molcel_2013_03_014 crossref_primary_10_1002_stem_3181 crossref_primary_10_1002_term_414 crossref_primary_10_1371_journal_pone_0232759 crossref_primary_10_3389_fimmu_2023_1214425 crossref_primary_10_3103_S0095452725040024 crossref_primary_10_1371_journal_pone_0036471 crossref_primary_10_1111_jnc_12084 crossref_primary_10_1007_s11596_018_1907_0 crossref_primary_10_1371_journal_pone_0189974 crossref_primary_10_3390_jcm3041511 crossref_primary_10_1038_nature10106 crossref_primary_10_1016_j_mrrev_2012_09_001 crossref_primary_10_1088_0034_4885_78_3_036602 crossref_primary_10_1016_j_brainres_2012_01_069 crossref_primary_10_1111_j_1749_6632_2012_06508_x crossref_primary_10_1002_stem_3290 crossref_primary_10_1016_j_biomaterials_2021_121273 crossref_primary_10_1016_j_semcancer_2014_07_001 crossref_primary_10_1038_nrm3036 crossref_primary_10_1186_gm252 crossref_primary_10_1038_nrg3473 crossref_primary_10_1016_j_theriogenology_2012_03_031 crossref_primary_10_1074_jbc_M113_465443 crossref_primary_10_1016_j_jcyt_2015_02_001 crossref_primary_10_1002_term_2405 crossref_primary_10_1073_pnas_1102454108 crossref_primary_10_1038_s41586_023_06424_7 crossref_primary_10_1124_pr_112_007393 crossref_primary_10_1038_s41418_018_0181_9 crossref_primary_10_1016_j_ajpath_2011_10_036 crossref_primary_10_1016_j_jcyt_2018_01_002 crossref_primary_10_1038_nmeth_1703 crossref_primary_10_1016_j_pneurobio_2015_09_009 crossref_primary_10_1016_j_devcel_2015_09_005 crossref_primary_10_1007_s00018_014_1829_3 crossref_primary_10_1371_journal_pone_0018265 crossref_primary_10_3390_cells10112863 crossref_primary_10_1093_biolre_ioaa053 crossref_primary_10_1136_jitc_2022_005126 crossref_primary_10_1007_s12015_011_9325_8 crossref_primary_10_5694_j_1326_5377_2011_tb03760_x crossref_primary_10_3390_ijms24032710 crossref_primary_10_1371_journal_pcbi_1003165 crossref_primary_10_1038_nchembio_611 crossref_primary_10_1016_j_ejmech_2023_115513 crossref_primary_10_1038_cr_2015_74 crossref_primary_10_1002_emmm_201200220 crossref_primary_10_2217_epi_11_15 crossref_primary_10_1016_j_jgeb_2018_09_002 crossref_primary_10_1007_s12038_019_9923_1 crossref_primary_10_1016_j_scr_2019_101387 crossref_primary_10_1016_j_chembiol_2013_06_005 crossref_primary_10_1134_S0362119717080114 crossref_primary_10_1371_journal_pone_0038454 crossref_primary_10_1161_CIRCRESAHA_112_278820 crossref_primary_10_1038_s41551_023_01140_z crossref_primary_10_4065_mcp_2011_0325 crossref_primary_10_1073_pnas_1908180116 crossref_primary_10_1371_journal_pone_0037129 crossref_primary_10_1016_j_addr_2018_06_020 crossref_primary_10_1016_j_biomaterials_2022_121939 crossref_primary_10_1016_j_marenvres_2017_06_018 crossref_primary_10_1038_srep46276 crossref_primary_10_1002_prp2_56 crossref_primary_10_1016_j_febslet_2012_08_018 crossref_primary_10_1161_CIRCRESAHA_111_249052 crossref_primary_10_1155_2012_365932 crossref_primary_10_1161_ATVBAHA_110_213959 crossref_primary_10_1002_jcp_25067 crossref_primary_10_1038_s43587_022_00233_9 crossref_primary_10_3390_biom9120813 crossref_primary_10_1038_mtm_2015_30 crossref_primary_10_1161_CIRCRESAHA_112_277863 crossref_primary_10_1111_j_1365_2443_2012_01595_x crossref_primary_10_1002_stem_1382 crossref_primary_10_1016_j_bmcl_2012_02_085 crossref_primary_10_1016_j_biopsych_2013_10_027 crossref_primary_10_1002_zoo_21284 crossref_primary_10_1007_s00005_021_00640_7 crossref_primary_10_1007_s12015_011_9313_z crossref_primary_10_1111_cpr_13425 crossref_primary_10_1073_pnas_1708991114 crossref_primary_10_1016_j_stem_2010_05_022 crossref_primary_10_1038_nmeth_1989 crossref_primary_10_1007_s00018_018_2841_9 crossref_primary_10_1016_j_phrs_2015_03_003 crossref_primary_10_1186_s12987_020_00183_7 crossref_primary_10_1161_CIRCGENETICS_113_000298 crossref_primary_10_3390_biom10010142 crossref_primary_10_4252_wjsc_v4_i8_87 crossref_primary_10_3390_ph4060848 crossref_primary_10_1215_18752160_4202323 crossref_primary_10_1016_j_yjmcc_2010_10_027 crossref_primary_10_1080_07391102_2020_1860822 crossref_primary_10_1002_biot_201200201 crossref_primary_10_1089_rej_2010_1140 crossref_primary_10_2217_rme_16_5 crossref_primary_10_1007_s00281_011_0262_z crossref_primary_10_1016_j_tcb_2015_08_006 crossref_primary_10_1113_JP271769 crossref_primary_10_1038_nature11044 crossref_primary_10_1242_dev_083279 crossref_primary_10_1038_nature12253 crossref_primary_10_1177_0271678X18788769 crossref_primary_10_1007_s12015_013_9429_4 crossref_primary_10_1038_s41598_017_06569_2 crossref_primary_10_3727_096368912X655208 crossref_primary_10_1002_stem_1497 crossref_primary_10_1371_journal_pone_0146791 crossref_primary_10_1016_j_neo_2020_12_007 crossref_primary_10_1089_cell_2020_0024 crossref_primary_10_1016_j_scr_2015_09_012 crossref_primary_10_3390_cells9030557 crossref_primary_10_1038_scibx_2013_481 crossref_primary_10_1038_srep15014 crossref_primary_10_1016_j_scitotenv_2020_144565 crossref_primary_10_1186_scrt44 crossref_primary_10_1002_stem_1169 crossref_primary_10_1016_j_csbj_2020_02_004 crossref_primary_10_1242_dev_146506 crossref_primary_10_1371_journal_pone_0076875 crossref_primary_10_3109_01677063_2013_789512 crossref_primary_10_1146_annurev_pathol_020117_043935 crossref_primary_10_1016_j_mrfmmm_2011_05_018 crossref_primary_10_1002_stem_3453 crossref_primary_10_3389_fendo_2025_1591152 crossref_primary_10_1002_stem_2243 crossref_primary_10_1073_pnas_1112664108 crossref_primary_10_1089_ten_teb_2012_0723 crossref_primary_10_1016_j_leukres_2011_10_010 crossref_primary_10_1016_j_devcel_2014_06_022 crossref_primary_10_4049_jimmunol_1502266 crossref_primary_10_3390_ijms12128661 crossref_primary_10_1007_s00441_019_03164_x crossref_primary_10_1038_micronano_2017_13 crossref_primary_10_3109_01677063_2015_1053478
Cites_doi	10.1242/jcs.1.1.1 10.1038/325816a0 10.1038/nature04914 10.1038/nature05944 10.1016/0092-8674(79)90317-9 10.1016/j.stem.2009.12.001 10.1038/nature06159 10.1038/nature08533 10.1016/j.stem.2008.12.010 10.1083/jcb.112.5.781 10.1016/j.cell.2007.11.019 10.1038/nature08285 10.1038/nbt.1535 10.1038/nature07314 10.1016/0092-8674(86)90885-8 10.1016/0012-1606(67)90058-9 10.1038/28615 10.1073/pnas.68.12.3026 10.1128/MCB.24.13.5710-5720.2004 10.1038/nature08235 10.1073/pnas.78.12.7634 10.1371/journal.pgen.1000170 10.1016/j.stem.2007.05.014 10.1038/nature02375 10.1126/science.1151526 10.1038/nature07863 10.1038/nature08592 10.1016/S0022-2836(61)80072-7 10.1073/pnas.0806166105 10.1038/nature06357 10.1242/jcs.041376 10.1126/science.290.5496.1578 10.1038/35030301 10.1038/nature08752 10.1096/fj.08-122903 10.1038/nature08797 10.1016/j.stem.2009.08.001 10.1093/emboj/16.21.6510 10.1016/S0960-9822(01)00459-6 10.1073/pnas.0700181104 10.1038/cr.2010.30 10.1242/jcs.02945 10.1038/223363a0 10.1016/j.cell.2009.03.034 10.1046/j.1365-2443.1996.11011.x 10.1126/science.1158799 10.1038/nature08287 10.1083/jcb.102.1.124 10.1126/science.1063206 10.1146/annurev.bi.61.070192.010025 10.1172/JCI41801 10.1073/pnas.38.5.455 10.1016/0092-8674(87)90585-X 10.1016/j.cell.2006.07.024 10.1016/0012-1606(62)90043-X 10.1073/pnas.56.5.1437 10.1126/science.1116447 10.1038/292154a0 10.1038/344454a0 10.1128/MCB.23.8.2699-2708.2003 10.1038/nature08180 10.1073/pnas.69.3.571 10.1073/pnas.0337659100 10.1038/385810a0 10.1038/nbt1374 10.1126/science.2414846 10.1016/j.cell.2008.07.041 10.1038/ncb1720 10.1262/jrd.09-221A 10.1038/ng.428 10.1101/gad.2.3.330 10.1016/0092-8674(83)90300-8 10.1038/nbt.1503 10.1038/ng1973 10.1038/nature718 10.1126/science.1153069 10.1038/nature08311 10.1016/0012-1606(66)90058-3 10.1016/0092-8674(85)90155-2 10.1038/nature05879 10.1073/pnas.69.4.951 10.1038/ncb1176 10.1242/dev.127.4.693 10.1038/nature05934 10.1016/j.stem.2007.12.001 10.1038/nbt1483 10.1016/j.stem.2007.05.012 10.1083/jcb.98.2.427 10.1016/j.ydbio.2005.01.016 10.1016/0092-8674(84)90423-9 10.1038/nature06534 10.1038/nature08290 10.1016/S0092-8674(04)00419-2
ContentType	Journal Article
Copyright	Springer Nature Limited 2010 COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Jun 10, 2010 2010 Macmillan Publishers Limited. All rights reserved 2010
Copyright_xml	– notice: Springer Nature Limited 2010 – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Jun 10, 2010 – notice: 2010 Macmillan Publishers Limited. All rights reserved 2010
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QG 7QL 7QP 7QR 7RV 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7X2 7X7 7XB 88A 88E 88G 88I 8AF 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK 8G5 ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BEC BENPR BGLVJ BHPHI BKSAR C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M2M M2O M2P M7N M7P M7S MBDVC NAPCQ P5Z P62 P64 PATMY PCBAR PDBOC PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS PSYQQ PTHSS PYCSY Q9U R05 RC3 S0X SOI 7X8 5PM
DOI	10.1038/nature09229
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Nursing & Allied Health Database (ProQuest) Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Meteorological & Geoastrophysical Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection (Proquest) ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Psychology Database (Alumni) Science Database (Alumni Edition) STEM Database ProQuest Pharma Collection Public Health Database (Proquest) Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection eLibrary ProQuest Central ProQuest Technology Collection Natural Science Collection Earth, Atmospheric & Aquatic Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Korea Engineering Research Database ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Research Library AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection ProQuest Biological Science Collection Agricultural Science Database ProQuest Health & Medical Collection Medical Database Psychology Database (ProQuest) Research Library Science Database (ProQuest) Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Research Library (Corporate) Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Earth, Atmospheric & Aquatic Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology Engineering Collection Environmental Science Collection ProQuest Central Basic University of Michigan Genetics Abstracts SIRS Editorial Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database ProQuest One Psychology Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts elibrary ProQuest AP Science SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Earth, Atmospheric & Aquatic Science Database Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) University of Michigan Technology Collection Technology Research Database ProQuest One Academic Middle East (New) SIRS Editorial Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Earth, Atmospheric & Aquatic Science Collection ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Research Library ProQuest Materials Science Collection ProQuest Public Health ProQuest Central Basic ProQuest Science Journals ProQuest Nursing & Allied Health Source ProQuest Psychology Journals (Alumni) ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library ProQuest Psychology Journals Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE Agricultural Science Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PATMY name: Environmental Science Database url: http://search.proquest.com/environmentalscience sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Sciences (General) Physics
EISSN	1476-4687
EndPage	712
ExternalDocumentID	PMC2901154 2065591851 A229068299 20535199 10_1038_nature09229
Genre	Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NHLBI NIH HHS grantid: HL096113 – fundername: NIA NIH HHS grantid: R37 AG009521 – fundername: NHLBI NIH HHS grantid: U01 HL100397 – fundername: NIA NIH HHS grantid: AG020961 – fundername: NIA NIH HHS grantid: AG009521 – fundername: NIA NIH HHS grantid: R01 AG009521 – fundername: NHLBI NIH HHS grantid: R01 HL096113 – fundername: NIA NIH HHS grantid: R01 AG020961
GroupedDBID	--- --Z -DZ -ET -~X .-4 .55 .CO .HR .XZ 00M 07C 0R~ 0WA 123 186 1OL 1VR 29M 2KS 2XV 39C 3O- 3V. 4.4 41X 53G 5RE 6TJ 70F 7RV 7X2 7X7 7XC 85S 88A 88E 88I 8AF 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ 8G5 8R4 8R5 8WZ 97F 97L A6W A7Z A8Z AAEEF AAHBH AAHTB AAIKC AAKAB AAKAS AAMNW AASDW AAYEP AAYZH ABAWZ ABDBF ABDQB ABFSI ABIVO ABJCF ABJNI ABLJU ABNNU ABOCM ABPEJ ABPPZ ABUWG ABWJO ABZEH ACBEA ACBWK ACGFO ACGFS ACGOD ACIWK ACKOT ACMJI ACNCT ACPRK ACRPL ACUHS ACWUS ADBBV ADFRT ADNMO ADUKH ADYSU ADZCM AENEX AEUYN AFFDN AFFNX AFKRA AFLOW AFRAH AFSHS AGAYW AGCDD AGGDT AGHSJ AGHTU AGNAY AGSOS AHMBA AHSBF AIDAL AIDUJ AIYXT ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH APEBS ARAPS ARMCB ARTTT ASPBG ATCPS ATWCN AVWKF AXYYD AZFZN AZQEC B0M BBNVY BCR BCU BDKGC BEC BENPR BES BGLVJ BHPHI BIN BKEYQ BKKNO BKSAR BLC BPHCQ BVXVI CCPQU CJ0 CS3 D1I D1J D1K DO4 DU5 DWQXO E.- E.L EAD EAP EAS EAZ EBC EBD EBO EBS ECC EE. EJD EMB EMF EMH EMK EMOBN EPL EPS ESE ESN ESX EX3 EXGXG F5P FEDTE FQGFK FSGXE FYUFA GNUQQ GUQSH HCIFZ HMCUK HVGLF HZ~ I-F IAO ICQ IEA IEP IGS IH2 IHR INH INR IOF IPY ISR ITC K6- KB. KOO L-9 L6V L7B LK5 LK8 LSO M0K M0L M1P M2M M2O M2P M7P M7R M7S N9A NAPCQ NEJ NEPJS O9- OBC OES OHH OHT OMK OVD P-O P2P P62 PATMY PCBAR PDBOC PEA PKN PM3 PQQKQ PROAC PSQYO PSYQQ PTHSS PYCSY Q2X R05 RND RNS RNT RNTTT RXW S0X SC5 SHXYY SIXXV SJFOW SJN SNYQT SOJ SV3 TAE TAOOD TBHMF TDRGL TEORI TH9 TN5 TSG TUS TWZ U5U UIG UKHRP UKR UMD UQL VQA VVN WH7 WOW X7M XIH XKW XZL Y6R YAE YCJ YFH YIF YIN YNT YOC YQT YR2 YR5 YXB YYP YZZ Z5M ZCA ZE2 ZKB ~02 ~7V ~88 ~8M ~G0 ~KM AARCD AAYXX ABFSG ABUFD ACSTC ADXHL AETEA AFANA AFFHD AGQPQ ALPWD ATHPR CITATION PHGZM PHGZT PJZUB PPXIY PQGLB ACMFV CGR CUY CVF ECM EIF NPM PMFND AEIIB 7QG 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7TG 7TK 7TM 7TO 7U9 7XB 8FD 8FK C1K ESTFP FR3 H94 K9. KL. M7N MBDVC P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 5PM
ID	FETCH-LOGICAL-c676t-fcf7e45ddf44f6aae9d6634da12ca0e3e2cfc27b2de6e46797190033404f105f3
IEDL.DBID	M2M
ISICitedReferencesCount	573
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000278551800032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0028-0836 1476-4687
IngestDate	Tue Nov 04 01:59:58 EST 2025 Sun Nov 09 10:54:06 EST 2025 Thu Dec 04 04:21:35 EST 2025 Mon Nov 24 16:08:36 EST 2025 Mon Nov 24 15:55:17 EST 2025 Tue Jun 10 15:37:12 EDT 2025 Sun Nov 23 08:59:15 EST 2025 Wed Nov 26 11:08:59 EST 2025 Sat May 31 02:09:39 EDT 2025 Tue Nov 18 21:02:58 EST 2025 Sat Nov 29 03:17:58 EST 2025 Fri Feb 21 02:37:58 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	7299
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c676t-fcf7e45ddf44f6aae9d6634da12ca0e3e2cfc27b2de6e46797190033404f105f3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
OpenAccessLink	https://www.ncbi.nlm.nih.gov/pmc/articles/2901154
PMID	20535199
PQID	518151515
PQPubID	40569
PageCount	9
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_2901154 proquest_miscellaneous_733261693 proquest_journals_518151515 gale_infotracmisc_A229068299 gale_infotracgeneralonefile_A229068299 gale_infotraccpiq_229068299 gale_infotracacademiconefile_A229068299 gale_incontextgauss_ISR_A229068299 pubmed_primary_20535199 crossref_citationtrail_10_1038_nature09229 crossref_primary_10_1038_nature09229 springer_journals_10_1038_nature09229
PublicationCentury	2000
PublicationDate	2010-06-10
PublicationDateYYYYMMDD	2010-06-10
PublicationDate_xml	– month: 06 year: 2010 text: 2010-06-10 day: 10
PublicationDecade	2010
PublicationPlace	London
PublicationPlace_xml	– name: London – name: England
PublicationSubtitle	International weekly journal of science
PublicationTitle	Nature (London)
PublicationTitleAbbrev	Nature
PublicationTitleAlternate	Nature
PublicationYear	2010
Publisher	Nature Publishing Group UK Nature Publishing Group
Publisher_xml	– name: Nature Publishing Group UK – name: Nature Publishing Group
References	Le Lievre, Le Douarin (CR5) 1975; 34 Pavlath, Blau (CR30) 1986; 102 Farah (CR54) 2000; 127 Gurdon (CR8) 1962; 4 Aasen (CR65) 2008; 26 Takahashi, Yamanaka (CR56) 2006; 126 Hadorn (CR3) 1966; 13 Schafer, Blakely, Darlington, Blau (CR55) 1990; 344 Kucharski, Maleszka, Foret, Maleszka (CR19) 2008; 319 Xie, Ye, Feng, Graf (CR51) 2004; 117 Daley (CR98) 2010; 120 Kawamura (CR73) 2009; 460 Hanna (CR79) 2009; 462 Eggan (CR12) 2004; 428 Wakayama (CR15) 2008; 105 Palermo (CR83) 2009; 23 Tokuzawa (CR58) 2003; 23 Taylor, Jones (CR50) 1979; 17 Rideout, Eggan, Jaenisch (CR90) 2001; 293 Zhang, Pomerantz, Sen, Palermo, Blau (CR84) 2007; 104 Gehring (CR4) 1967; 16 Peterson, Weiss (CR27) 1972; 69 Simonsson, Gurdon (CR18) 2004; 6 Harris, Miller, Klein, Worst, Tachibana (CR26) 1969; 223 Spear, Tilghman (CR36) 1990; 10 Yamanaka (CR80) 2009; 460 Hong (CR74) 2009; 460 Schneuwly, Klemenz, Gehring (CR47) 1987; 325 Judson, Babiarz, Venere, Blelloch (CR75) 2009; 27 Harris, Watkins, Ford, Schoefl (CR29) 1966; 1 Weimann, Charlton, Brazelton, Hackman, Blau (CR38) 2003; 100 Wernig (CR59) 2007; 448 Tada, Tada, Lefebvre, Barton, Surani (CR39) 1997; 16 Park (CR64) 2008; 451 Yamanaka (CR67) 2009; 137 Jacob, Monod (CR87) 1961; 3 Ptashne (CR88) 1986 Yoshida, Takahashi, Okita, Ichisaka, Yamanaka (CR68) 2009; 5 Blau, Baltimore (CR22) 1991; 112 Nakagawa (CR61) 2008; 26 Blau (CR21) 1985; 230 Cowan, Atienza, Melton, Eggan (CR42) 2005; 309 Wakayama, Perry, Zuccotti, Johnson, Yanagimachi (CR10) 1998; 394 Weiss, Chaplain (CR24) 1971; 68 Okita, Ichisaka, Yamanaka (CR60) 2007; 448 Utikal (CR72) 2009; 460 Vierbuchen (CR82) 2010; 463 Kimura, Tada, Nakatsuji, Tada (CR41) 2004; 24 Takahashi (CR63) 2007; 131 Tada, Takahama, Abe, Nakatsuji, Tada (CR40) 2001; 11 Davidson, Ephrussi, Yamamoto (CR23) 1966; 56 Marion (CR71) 2009; 460 Zhou, Brown, Kanarek, Rajagopal, Melton (CR81) 2008; 455 Nolen (CR94) 2005; 279 Blau, Chiu, Webster (CR20) 1983; 32 Yang (CR16) 2007; 39 Esteban (CR69) 2010; 6 Eminli (CR76) 2009; 41 Gehring (CR48) 1996; 1 Graf, Enver (CR53) 2009; 462 Egli, Rosains, Birkhoff, Eggan (CR13) 2007; 447 Terranova, Pereira, Du Roure, Merkenschlager, Fisher (CR86) 2006; 119 Evans, Kaufman (CR1) 1981; 292 Baron, Maniatis (CR35) 1986; 46 Cobaleda, Jochum, Busslinger (CR52) 2007; 449 Wernig, Meissner, Cassady, Jaenisch (CR62) 2008; 2 Wilmut, Schnieke, McWhir, Kind, Campbell (CR9) 1997; 385 Park (CR97) 2008; 134 Wright (CR34) 1984; 98 Blau (CR89) 1992; 61 Silva, Chambers, Pollard, Smith (CR43) 2006; 441 Thuan, Kishigami, Wakayama (CR14) 2010; 56 Ringertz, Savage (CR25) 1977 Dimos (CR96) 2008; 321 Maherali (CR95) 2007; 1 Woltjen (CR78) 2009; 458 Wakayama (CR91) 2000; 407 Martin (CR2) 1981; 78 Hochedlinger, Jaenisch (CR11) 2002; 415 Li (CR70) 2009; 460 Davis, Weintraub, Lassar (CR49) 1987; 51 Wernig (CR77) 2008; 26 Bhutani (CR45) 2010; 463 Johansson (CR37) 2008; 10 Davidson (CR28) 1972; 69 Pereira (CR44) 2008; 4 Chiu, Blau (CR31) 1984; 37 Agarwal, Daley (CR46) 2010; 20 Gurdon (CR7) 1962; 10 Eggan (CR93) 2000; 290 Miller, Pavlath, Blakely, Blau (CR32) 1988; 2 Yamanaka (CR57) 2007; 1 Byrne (CR17) 2007; 450 Marion (CR92) 2009; 4 Briggs, King (CR6) 1952; 38 Chiu, Blau (CR33) 1985; 40 Yu (CR66) 2007; 318 Pomerantz, Mukherjee, Palermo, Blau (CR85) 2009; 122 CP Chiu (BFnature09229_CR33) 1985; 40 K Eggan (BFnature09229_CR93) 2000; 290 BW Schafer (BFnature09229_CR55) 1990; 344 RL Davidson (BFnature09229_CR28) 1972; 69 M Wernig (BFnature09229_CR59) 2007; 448 H Harris (BFnature09229_CR26) 1969; 223 MH Farah (BFnature09229_CR54) 2000; 127 S Eminli (BFnature09229_CR76) 2009; 41 M Wernig (BFnature09229_CR62) 2008; 2 Q Zhou (BFnature09229_CR81) 2008; 455 JA Peterson (BFnature09229_CR27) 1972; 69 T Wakayama (BFnature09229_CR91) 2000; 407 S Yamanaka (BFnature09229_CR57) 2007; 1 CF Pereira (BFnature09229_CR44) 2008; 4 T Kawamura (BFnature09229_CR73) 2009; 460 M Tada (BFnature09229_CR39) 1997; 16 J Silva (BFnature09229_CR43) 2006; 441 JT Dimos (BFnature09229_CR96) 2008; 321 Y Yoshida (BFnature09229_CR68) 2009; 5 BT Spear (BFnature09229_CR36) 1990; 10 LD Nolen (BFnature09229_CR94) 2005; 279 IH Park (BFnature09229_CR97) 2008; 134 K Eggan (BFnature09229_CR12) 2004; 428 T Wakayama (BFnature09229_CR10) 1998; 394 WM Rideout (BFnature09229_CR90) 2001; 293 N Maherali (BFnature09229_CR95) 2007; 1 H Hong (BFnature09229_CR74) 2009; 460 RL Judson (BFnature09229_CR75) 2009; 27 GQ Daley (BFnature09229_CR98) 2010; 120 NR Ringertz (BFnature09229_CR25) 1977 SC Miller (BFnature09229_CR32) 1988; 2 RM Marion (BFnature09229_CR71) 2009; 460 M Tada (BFnature09229_CR40) 2001; 11 WE Wright (BFnature09229_CR34) 1984; 98 S Wakayama (BFnature09229_CR15) 2008; 105 SM Taylor (BFnature09229_CR50) 1979; 17 H Kimura (BFnature09229_CR41) 2004; 24 K Woltjen (BFnature09229_CR78) 2009; 458 MJ Evans (BFnature09229_CR1) 1981; 292 K Takahashi (BFnature09229_CR63) 2007; 131 J Hanna (BFnature09229_CR79) 2009; 462 X Yang (BFnature09229_CR16) 2007; 39 H Harris (BFnature09229_CR29) 1966; 1 T Graf (BFnature09229_CR53) 2009; 462 JB Gurdon (BFnature09229_CR8) 1962; 4 HM Blau (BFnature09229_CR20) 1983; 32 T Vierbuchen (BFnature09229_CR82) 2010; 463 D Egli (BFnature09229_CR13) 2007; 447 A Palermo (BFnature09229_CR83) 2009; 23 W Gehring (BFnature09229_CR4) 1967; 16 MH Baron (BFnature09229_CR35) 1986; 46 HM Blau (BFnature09229_CR21) 1985; 230 M Nakagawa (BFnature09229_CR61) 2008; 26 S Schneuwly (BFnature09229_CR47) 1987; 325 CS Le Lievre (BFnature09229_CR5) 1975; 34 HM Blau (BFnature09229_CR89) 1992; 61 K Takahashi (BFnature09229_CR56) 2006; 126 RM Marion (BFnature09229_CR92) 2009; 4 R Kucharski (BFnature09229_CR19) 2008; 319 R Terranova (BFnature09229_CR86) 2006; 119 M Wernig (BFnature09229_CR77) 2008; 26 K Okita (BFnature09229_CR60) 2007; 448 F Zhang (BFnature09229_CR84) 2007; 104 J Yu (BFnature09229_CR66) 2007; 318 N Bhutani (BFnature09229_CR45) 2010; 463 J Utikal (BFnature09229_CR72) 2009; 460 CA Cowan (BFnature09229_CR42) 2005; 309 MA Esteban (BFnature09229_CR69) 2010; 6 JM Weimann (BFnature09229_CR38) 2003; 100 JH Pomerantz (BFnature09229_CR85) 2009; 122 NV Thuan (BFnature09229_CR14) 2010; 56 E Hadorn (BFnature09229_CR3) 1966; 13 Y Tokuzawa (BFnature09229_CR58) 2003; 23 F Jacob (BFnature09229_CR87) 1961; 3 S Yamanaka (BFnature09229_CR80) 2009; 460 I Wilmut (BFnature09229_CR9) 1997; 385 JB Gurdon (BFnature09229_CR7) 1962; 10 S Yamanaka (BFnature09229_CR67) 2009; 137 CP Chiu (BFnature09229_CR31) 1984; 37 H Xie (BFnature09229_CR51) 2004; 117 GR Martin (BFnature09229_CR2) 1981; 78 JA Byrne (BFnature09229_CR17) 2007; 450 GK Pavlath (BFnature09229_CR30) 1986; 102 MC Weiss (BFnature09229_CR24) 1971; 68 CB Johansson (BFnature09229_CR37) 2008; 10 WJ Gehring (BFnature09229_CR48) 1996; 1 S Simonsson (BFnature09229_CR18) 2004; 6 C Cobaleda (BFnature09229_CR52) 2007; 449 T Aasen (BFnature09229_CR65) 2008; 26 H Li (BFnature09229_CR70) 2009; 460 RL Davidson (BFnature09229_CR23) 1966; 56 M Ptashne (BFnature09229_CR88) 1986 K Hochedlinger (BFnature09229_CR11) 2002; 415 IH Park (BFnature09229_CR64) 2008; 451 R Briggs (BFnature09229_CR6) 1952; 38 HM Blau (BFnature09229_CR22) 1991; 112 S Agarwal (BFnature09229_CR46) 2010; 20 RL Davis (BFnature09229_CR49) 1987; 51
References_xml	– volume: 1 start-page: 1 year: 1966 end-page: 30 ident: CR29 article-title: Artificial heterokaryons of animal cells from different species publication-title: J. Cell Sci. doi: 10.1242/jcs.1.1.1 – volume: 325 start-page: 816 year: 1987 end-page: 818 ident: CR47 article-title: Redesigning the body plan of by ectopic expression of the homoeotic gene publication-title: Nature doi: 10.1038/325816a0 – volume: 441 start-page: 997 year: 2006 end-page: 1001 ident: CR43 article-title: Nanog promotes transfer of pluripotency after cell fusion publication-title: Nature doi: 10.1038/nature04914 – volume: 448 start-page: 318 year: 2007 end-page: 324 ident: CR59 article-title: reprogramming of fibroblasts into a pluripotent ES-cell-like state publication-title: Nature doi: 10.1038/nature05944 – volume: 17 start-page: 771 year: 1979 end-page: 779 ident: CR50 article-title: Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine publication-title: Cell doi: 10.1016/0092-8674(79)90317-9 – volume: 6 start-page: 71 year: 2010 end-page: 79 ident: CR69 article-title: Vitamin C enhances the generation of mouse and human induced pluripotent stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.12.001 – volume: 449 start-page: 473 year: 2007 end-page: 477 ident: CR52 article-title: Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors publication-title: Nature doi: 10.1038/nature06159 – volume: 462 start-page: 587 year: 2009 end-page: 594 ident: CR53 article-title: Forcing cells to change lineages publication-title: Nature doi: 10.1038/nature08533 – year: 1986 ident: CR88 publication-title: A Genetic Switch: Gene Control and Phage Lambda – year: 1977 ident: CR25 publication-title: Cell Hybrids – volume: 4 start-page: 141 year: 2009 end-page: 154 ident: CR92 article-title: Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.12.010 – volume: 112 start-page: 781 year: 1991 end-page: 783 ident: CR22 article-title: Differentiation requires continuous regulation publication-title: J. Cell Biol. doi: 10.1083/jcb.112.5.781 – volume: 131 start-page: 861 year: 2007 end-page: 872 ident: CR63 article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 460 start-page: 1145 year: 2009 end-page: 1148 ident: CR72 article-title: Immortalization eliminates a roadblock during cellular reprogramming into iPS cells publication-title: Nature doi: 10.1038/nature08285 – volume: 10 start-page: 5047 year: 1990 end-page: 5054 ident: CR36 article-title: Role of α-fetoprotein regulatory elements in transcriptional activation in transient heterokaryons publication-title: Mol. Cell Biol. – volume: 27 start-page: 459 year: 2009 end-page: 461 ident: CR75 article-title: Embryonic stem cell-specific microRNAs promote induced pluripotency publication-title: Nature Biotechnol. doi: 10.1038/nbt.1535 – volume: 455 start-page: 627 year: 2008 end-page: 632 ident: CR81 article-title: reprogramming of adult pancreatic exocrine cells to β-cells publication-title: Nature doi: 10.1038/nature07314 – volume: 46 start-page: 591 year: 1986 end-page: 602 ident: CR35 article-title: Rapid reprogramming of globin gene expression in transient heterokaryons publication-title: Cell doi: 10.1016/0092-8674(86)90885-8 – volume: 16 start-page: 438 year: 1967 end-page: 456 ident: CR4 article-title: Clonal analysis of determination dynamics in cultures of imaginal disks in publication-title: Dev. Biol. doi: 10.1016/0012-1606(67)90058-9 – volume: 394 start-page: 369 year: 1998 end-page: 374 ident: CR10 article-title: Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei publication-title: Nature doi: 10.1038/28615 – volume: 68 start-page: 3026 year: 1971 end-page: 3030 ident: CR24 article-title: Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.68.12.3026 – volume: 24 start-page: 5710 year: 2004 end-page: 5720 ident: CR41 article-title: Histone code modifications on pluripotential nuclei of reprogrammed somatic cells publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.13.5710-5720.2004 – volume: 460 start-page: 1132 year: 2009 end-page: 1135 ident: CR74 article-title: Suppression of induced pluripotent stem cell generation by the p53–p21 pathway publication-title: Nature doi: 10.1038/nature08235 – volume: 78 start-page: 7634 year: 1981 end-page: 7638 ident: CR2 article-title: Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.78.12.7634 – volume: 4 start-page: e1000170 year: 2008 ident: CR44 article-title: Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000170 – volume: 1 start-page: 55 year: 2007 end-page: 70 ident: CR95 article-title: Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.05.014 – volume: 428 start-page: 44 year: 2004 end-page: 49 ident: CR12 article-title: Mice cloned from olfactory sensory neurons publication-title: Nature doi: 10.1038/nature02375 – volume: 318 start-page: 1917 year: 2007 end-page: 1920 ident: CR66 article-title: Induced pluripotent stem cell lines derived from human somatic cells publication-title: Science doi: 10.1126/science.1151526 – volume: 458 start-page: 766 year: 2009 end-page: 770 ident: CR78 article-title: transposition reprograms fibroblasts to induced pluripotent stem cells publication-title: Nature doi: 10.1038/nature07863 – volume: 462 start-page: 595 year: 2009 end-page: 601 ident: CR79 article-title: Direct cell reprogramming is a stochastic process amenable to acceleration publication-title: Nature doi: 10.1038/nature08592 – volume: 3 start-page: 318 year: 1961 end-page: 356 ident: CR87 article-title: Genetic regulatory mechanisms in the synthesis of proteins publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(61)80072-7 – volume: 105 start-page: 17318 year: 2008 end-page: 17322 ident: CR15 article-title: Production of healthy cloned mice from bodies frozen at −20 degrees C for 16 years publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0806166105 – volume: 450 start-page: 497 year: 2007 end-page: 502 ident: CR17 article-title: Producing primate embryonic stem cells by somatic cell nuclear transfer publication-title: Nature doi: 10.1038/nature06357 – volume: 122 start-page: 1045 year: 2009 end-page: 1053 ident: CR85 article-title: Reprogramming to a muscle fate by fusion recapitulates differentiation publication-title: J. Cell Sci. doi: 10.1242/jcs.041376 – volume: 290 start-page: 1578 year: 2000 end-page: 1581 ident: CR93 article-title: X-chromosome inactivation in cloned mouse embryos publication-title: Science doi: 10.1126/science.290.5496.1578 – volume: 407 start-page: 318 year: 2000 end-page: 319 ident: CR91 article-title: Cloning of mice to six generations publication-title: Nature doi: 10.1038/35030301 – volume: 463 start-page: 1042 year: 2010 end-page: 1047 ident: CR45 article-title: Reprogramming towards pluripotency requires AID-dependent DNA demethylation publication-title: Nature doi: 10.1038/nature08752 – volume: 23 start-page: 1431 year: 2009 end-page: 1440 ident: CR83 article-title: Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional publication-title: FASEB J. doi: 10.1096/fj.08-122903 – volume: 463 start-page: 1035 year: 2010 end-page: 1041 ident: CR82 article-title: Direct conversion of fibroblasts to functional neurons by defined factors publication-title: Nature doi: 10.1038/nature08797 – volume: 5 start-page: 237 year: 2009 end-page: 241 ident: CR68 article-title: Hypoxia enhances the generation of induced pluripotent stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.08.001 – volume: 16 start-page: 6510 year: 1997 end-page: 6520 ident: CR39 article-title: Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells publication-title: EMBO J. doi: 10.1093/emboj/16.21.6510 – volume: 11 start-page: 1553 year: 2001 end-page: 1558 ident: CR40 article-title: Nuclear reprogramming of somatic cells by hybridization with ES cells publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00459-6 – volume: 104 start-page: 4395 year: 2007 end-page: 4400 ident: CR84 article-title: Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0700181104 – volume: 20 start-page: 253 year: 2010 end-page: 255 ident: CR46 article-title: AID for reprogramming publication-title: Cell Res. doi: 10.1038/cr.2010.30 – volume: 119 start-page: 2065 year: 2006 end-page: 2072 ident: CR86 article-title: Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming publication-title: J. Cell Sci. doi: 10.1242/jcs.02945 – volume: 223 start-page: 363 year: 1969 end-page: 368 ident: CR26 article-title: Suppression of malignancy by cell fusion publication-title: Nature doi: 10.1038/223363a0 – volume: 137 start-page: 13 year: 2009 end-page: 17 ident: CR67 article-title: A fresh look at iPS cells publication-title: Cell doi: 10.1016/j.cell.2009.03.034 – volume: 1 start-page: 11 year: 1996 end-page: 15 ident: CR48 article-title: The master control gene for morphogenesis and evolution of the eye publication-title: Genes Cells doi: 10.1046/j.1365-2443.1996.11011.x – volume: 321 start-page: 1218 year: 2008 end-page: 1221 ident: CR96 article-title: Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons publication-title: Science doi: 10.1126/science.1158799 – volume: 34 start-page: 125 year: 1975 end-page: 154 ident: CR5 article-title: Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos publication-title: J. Embryol. Exp. Morphol. – volume: 460 start-page: 1149 year: 2009 end-page: 1153 ident: CR71 article-title: A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity publication-title: Nature doi: 10.1038/nature08287 – volume: 102 start-page: 124 year: 1986 end-page: 130 ident: CR30 article-title: Expression of muscle genes in heterokaryons depends on gene dosage publication-title: J. Cell Biol. doi: 10.1083/jcb.102.1.124 – volume: 293 start-page: 1093 year: 2001 end-page: 1098 ident: CR90 article-title: Nuclear cloning and epigenetic reprogramming of the genome publication-title: Science doi: 10.1126/science.1063206 – volume: 61 start-page: 1213 year: 1992 end-page: 1230 ident: CR89 article-title: Differentiation requires continuous active control publication-title: Annu. Rev.Biochem. doi: 10.1146/annurev.bi.61.070192.010025 – volume: 120 start-page: 8 year: 2010 end-page: 10 ident: CR98 article-title: Stem cells: roadmap to the clinic publication-title: J. Clin. Invest. doi: 10.1172/JCI41801 – volume: 38 start-page: 455 year: 1952 end-page: 463 ident: CR6 article-title: Transplantation of living nuclei from blastula cells into enucleated frogs' eggs publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.38.5.455 – volume: 51 start-page: 987 year: 1987 end-page: 1000 ident: CR49 article-title: Expression of a single transfected cDNA converts fibroblasts to myoblasts publication-title: Cell doi: 10.1016/0092-8674(87)90585-X – volume: 126 start-page: 663 year: 2006 end-page: 676 ident: CR56 article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 4 start-page: 256 year: 1962 end-page: 273 ident: CR8 article-title: Adult frogs derived from the nuclei of single somatic cells publication-title: Dev. Biol. doi: 10.1016/0012-1606(62)90043-X – volume: 56 start-page: 1437 year: 1966 end-page: 1440 ident: CR23 article-title: Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.56.5.1437 – volume: 309 start-page: 1369 year: 2005 end-page: 1373 ident: CR42 article-title: Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells publication-title: Science doi: 10.1126/science.1116447 – volume: 292 start-page: 154 year: 1981 end-page: 156 ident: CR1 article-title: Establishment in culture of pluripotential cells from mouse embryos publication-title: Nature doi: 10.1038/292154a0 – volume: 344 start-page: 454 year: 1990 end-page: 458 ident: CR55 article-title: Effect of cell history on response to helix–loop–helix family of myogenic regulators publication-title: Nature doi: 10.1038/344454a0 – volume: 23 start-page: 2699 year: 2003 end-page: 2708 ident: CR58 article-title: is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.8.2699-2708.2003 – volume: 460 start-page: 49 year: 2009 end-page: 52 ident: CR80 article-title: Elite and stochastic models for induced pluripotent stem cell generation publication-title: Nature doi: 10.1038/nature08180 – volume: 69 start-page: 571 year: 1972 end-page: 575 ident: CR27 article-title: Expression of differentiated functions in hepatoma cell hybrids: induction of mouse albumin production in rat hepatoma–mouse fibroblast hybrids publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.69.3.571 – volume: 100 start-page: 2088 year: 2003 end-page: 2093 ident: CR38 article-title: Contribution of transplanted bone marrow cells to Purkinje neurons in human adult brains publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0337659100 – volume: 385 start-page: 810 year: 1997 end-page: 813 ident: CR9 article-title: Viable offspring derived from fetal and adult mammalian cells publication-title: Nature doi: 10.1038/385810a0 – volume: 26 start-page: 101 year: 2008 end-page: 106 ident: CR61 article-title: Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts publication-title: Nature Biotechnol. doi: 10.1038/nbt1374 – volume: 230 start-page: 758 year: 1985 end-page: 766 ident: CR21 article-title: Plasticity of the differentiated state publication-title: Science doi: 10.1126/science.2414846 – volume: 134 start-page: 877 year: 2008 end-page: 886 ident: CR97 article-title: Disease-specific induced pluripotent stem cells publication-title: Cell doi: 10.1016/j.cell.2008.07.041 – volume: 10 start-page: 575 year: 2008 end-page: 583 ident: CR37 article-title: Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation publication-title: Nature Cell Biol. doi: 10.1038/ncb1720 – volume: 56 start-page: 20 year: 2010 end-page: 30 ident: CR14 article-title: How to improve the success rate of mouse cloning technology publication-title: J. Reprod. Dev. doi: 10.1262/jrd.09-221A – volume: 41 start-page: 968 year: 2009 end-page: 976 ident: CR76 article-title: Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells publication-title: Nature Genet. doi: 10.1038/ng.428 – volume: 10 start-page: 622 year: 1962 end-page: 640 ident: CR7 article-title: The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles publication-title: J. Embryol. Exp. Morphol. – volume: 2 start-page: 330 year: 1988 end-page: 340 ident: CR32 article-title: Muscle cell components dictate hepatocyte gene expression and the distribution of the Golgi apparatus in heterokaryons publication-title: Genes Dev. doi: 10.1101/gad.2.3.330 – volume: 32 start-page: 1171 year: 1983 end-page: 1180 ident: CR20 article-title: Cytoplasmic activation of human nuclear genes in stable heterocaryons publication-title: Cell doi: 10.1016/0092-8674(83)90300-8 – volume: 26 start-page: 1276 year: 2008 end-page: 1284 ident: CR65 article-title: Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes publication-title: Nature Biotechnol. doi: 10.1038/nbt.1503 – volume: 39 start-page: 295 year: 2007 end-page: 302 ident: CR16 article-title: Nuclear reprogramming of cloned embryos and its implications for therapeutic cloning publication-title: Nature Genet. doi: 10.1038/ng1973 – volume: 415 start-page: 1035 year: 2002 end-page: 1038 ident: CR11 article-title: Monoclonal mice generated by nuclear transfer from mature B and T donor cells publication-title: Nature doi: 10.1038/nature718 – volume: 319 start-page: 1827 year: 2008 end-page: 1830 ident: CR19 article-title: Nutritional control of reproductive status in honeybees via DNA methylation publication-title: Science doi: 10.1126/science.1153069 – volume: 460 start-page: 1140 year: 2009 end-page: 1144 ident: CR73 article-title: Linking the p53 tumour suppressor pathway to somatic cell reprogramming publication-title: Nature doi: 10.1038/nature08311 – volume: 13 start-page: 424 year: 1966 end-page: 509 ident: CR3 article-title: Constancy, variation and type of determination and differentiation in cells from male genitalia rudiments of in permanent culture [in German with English abstract] publication-title: Dev. Biol. doi: 10.1016/0012-1606(66)90058-3 – volume: 40 start-page: 417 year: 1985 end-page: 424 ident: CR33 article-title: 5-Azacytidine permits gene activation in a previously noninducible cell type publication-title: Cell doi: 10.1016/0092-8674(85)90155-2 – volume: 447 start-page: 679 year: 2007 end-page: 685 ident: CR13 article-title: Developmental reprogramming after chromosome transfer into mitotic mouse zygotes publication-title: Nature doi: 10.1038/nature05879 – volume: 69 start-page: 951 year: 1972 end-page: 955 ident: CR28 article-title: Regulation of melanin synthesis in mammalian cells: effect of gene dosage on the expression of differentiation publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.69.4.951 – volume: 6 start-page: 984 year: 2004 end-page: 990 ident: CR18 article-title: DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei publication-title: Nature Cell Biol. doi: 10.1038/ncb1176 – volume: 127 start-page: 693 year: 2000 end-page: 702 ident: CR54 article-title: Generation of neurons by transient expression of neural bHLH proteins in mammalian cells publication-title: Development doi: 10.1242/dev.127.4.693 – volume: 448 start-page: 313 year: 2007 end-page: 317 ident: CR60 article-title: Generation of germline-competent induced pluripotent stem cells publication-title: Nature doi: 10.1038/nature05934 – volume: 2 start-page: 10 year: 2008 end-page: 12 ident: CR62 article-title: c-Myc is dispensable for direct reprogramming of mouse fibroblasts publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.12.001 – volume: 26 start-page: 916 year: 2008 end-page: 924 ident: CR77 article-title: A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types publication-title: Nature Biotechnol. doi: 10.1038/nbt1483 – volume: 1 start-page: 39 year: 2007 end-page: 49 ident: CR57 article-title: Strategies and new developments in the generation of patient-specific 57 stem cells publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.05.012 – volume: 98 start-page: 427 year: 1984 end-page: 435 ident: CR34 article-title: Induction of muscle genes in neural cells publication-title: J. Cell Biol. doi: 10.1083/jcb.98.2.427 – volume: 279 start-page: 525 year: 2005 end-page: 540 ident: CR94 article-title: X chromosome reactivation and regulation in cloned embryos publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2005.01.016 – volume: 37 start-page: 879 year: 1984 end-page: 887 ident: CR31 article-title: Reprogramming cell differentiation in the absence of DNA synthesis publication-title: Cell doi: 10.1016/0092-8674(84)90423-9 – volume: 451 start-page: 141 year: 2008 end-page: 146 ident: CR64 article-title: Reprogramming of human somatic cells to pluripotency with defined factors publication-title: Nature doi: 10.1038/nature06534 – volume: 460 start-page: 1136 year: 2009 end-page: 1139 ident: CR70 article-title: The locus is a barrier for iPS cell reprogramming publication-title: Nature doi: 10.1038/nature08290 – volume: 117 start-page: 663 year: 2004 end-page: 676 ident: CR51 article-title: Stepwise reprogramming of B cells into macrophages publication-title: Cell doi: 10.1016/S0092-8674(04)00419-2 – volume: 32 start-page: 1171 year: 1983 ident: BFnature09229_CR20 publication-title: Cell doi: 10.1016/0092-8674(83)90300-8 – volume: 117 start-page: 663 year: 2004 ident: BFnature09229_CR51 publication-title: Cell doi: 10.1016/S0092-8674(04)00419-2 – volume: 120 start-page: 8 year: 2010 ident: BFnature09229_CR98 publication-title: J. Clin. Invest. doi: 10.1172/JCI41801 – volume: 16 start-page: 438 year: 1967 ident: BFnature09229_CR4 publication-title: Dev. Biol. doi: 10.1016/0012-1606(67)90058-9 – volume: 38 start-page: 455 year: 1952 ident: BFnature09229_CR6 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.38.5.455 – volume: 40 start-page: 417 year: 1985 ident: BFnature09229_CR33 publication-title: Cell doi: 10.1016/0092-8674(85)90155-2 – volume: 23 start-page: 2699 year: 2003 ident: BFnature09229_CR58 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.23.8.2699-2708.2003 – volume: 4 start-page: 141 year: 2009 ident: BFnature09229_CR92 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2008.12.010 – volume: 460 start-page: 1140 year: 2009 ident: BFnature09229_CR73 publication-title: Nature doi: 10.1038/nature08311 – volume: 39 start-page: 295 year: 2007 ident: BFnature09229_CR16 publication-title: Nature Genet. doi: 10.1038/ng1973 – volume: 10 start-page: 5047 year: 1990 ident: BFnature09229_CR36 publication-title: Mol. Cell Biol. – volume: 309 start-page: 1369 year: 2005 ident: BFnature09229_CR42 publication-title: Science doi: 10.1126/science.1116447 – volume: 137 start-page: 13 year: 2009 ident: BFnature09229_CR67 publication-title: Cell doi: 10.1016/j.cell.2009.03.034 – volume: 230 start-page: 758 year: 1985 ident: BFnature09229_CR21 publication-title: Science doi: 10.1126/science.2414846 – volume-title: Cell Hybrids year: 1977 ident: BFnature09229_CR25 – volume: 344 start-page: 454 year: 1990 ident: BFnature09229_CR55 publication-title: Nature doi: 10.1038/344454a0 – volume: 451 start-page: 141 year: 2008 ident: BFnature09229_CR64 publication-title: Nature doi: 10.1038/nature06534 – volume: 293 start-page: 1093 year: 2001 ident: BFnature09229_CR90 publication-title: Science doi: 10.1126/science.1063206 – volume: 13 start-page: 424 year: 1966 ident: BFnature09229_CR3 publication-title: Dev. Biol. doi: 10.1016/0012-1606(66)90058-3 – volume: 20 start-page: 253 year: 2010 ident: BFnature09229_CR46 publication-title: Cell Res. doi: 10.1038/cr.2010.30 – volume: 56 start-page: 20 year: 2010 ident: BFnature09229_CR14 publication-title: J. Reprod. Dev. doi: 10.1262/jrd.09-221A – volume: 127 start-page: 693 year: 2000 ident: BFnature09229_CR54 publication-title: Development doi: 10.1242/dev.127.4.693 – volume: 4 start-page: e1000170 year: 2008 ident: BFnature09229_CR44 publication-title: PLoS Genet. doi: 10.1371/journal.pgen.1000170 – volume: 321 start-page: 1218 year: 2008 ident: BFnature09229_CR96 publication-title: Science doi: 10.1126/science.1158799 – volume: 460 start-page: 1149 year: 2009 ident: BFnature09229_CR71 publication-title: Nature doi: 10.1038/nature08287 – volume: 441 start-page: 997 year: 2006 ident: BFnature09229_CR43 publication-title: Nature doi: 10.1038/nature04914 – volume: 462 start-page: 595 year: 2009 ident: BFnature09229_CR79 publication-title: Nature doi: 10.1038/nature08592 – volume: 10 start-page: 622 year: 1962 ident: BFnature09229_CR7 publication-title: J. Embryol. Exp. Morphol. – volume: 455 start-page: 627 year: 2008 ident: BFnature09229_CR81 publication-title: Nature doi: 10.1038/nature07314 – volume: 122 start-page: 1045 year: 2009 ident: BFnature09229_CR85 publication-title: J. Cell Sci. doi: 10.1242/jcs.041376 – volume: 462 start-page: 587 year: 2009 ident: BFnature09229_CR53 publication-title: Nature doi: 10.1038/nature08533 – volume: 34 start-page: 125 year: 1975 ident: BFnature09229_CR5 publication-title: J. Embryol. Exp. Morphol. – volume: 24 start-page: 5710 year: 2004 ident: BFnature09229_CR41 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.13.5710-5720.2004 – volume: 119 start-page: 2065 year: 2006 ident: BFnature09229_CR86 publication-title: J. Cell Sci. doi: 10.1242/jcs.02945 – volume: 51 start-page: 987 year: 1987 ident: BFnature09229_CR49 publication-title: Cell doi: 10.1016/0092-8674(87)90585-X – volume: 1 start-page: 55 year: 2007 ident: BFnature09229_CR95 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.05.014 – volume: 1 start-page: 11 year: 1996 ident: BFnature09229_CR48 publication-title: Genes Cells doi: 10.1046/j.1365-2443.1996.11011.x – volume: 6 start-page: 71 year: 2010 ident: BFnature09229_CR69 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.12.001 – volume: 450 start-page: 497 year: 2007 ident: BFnature09229_CR17 publication-title: Nature doi: 10.1038/nature06357 – volume: 102 start-page: 124 year: 1986 ident: BFnature09229_CR30 publication-title: J. Cell Biol. doi: 10.1083/jcb.102.1.124 – volume: 11 start-page: 1553 year: 2001 ident: BFnature09229_CR40 publication-title: Curr. Biol. doi: 10.1016/S0960-9822(01)00459-6 – volume: 1 start-page: 39 year: 2007 ident: BFnature09229_CR57 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.05.012 – volume: 69 start-page: 951 year: 1972 ident: BFnature09229_CR28 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.69.4.951 – volume: 134 start-page: 877 year: 2008 ident: BFnature09229_CR97 publication-title: Cell doi: 10.1016/j.cell.2008.07.041 – volume: 448 start-page: 313 year: 2007 ident: BFnature09229_CR60 publication-title: Nature doi: 10.1038/nature05934 – volume: 5 start-page: 237 year: 2009 ident: BFnature09229_CR68 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2009.08.001 – volume: 415 start-page: 1035 year: 2002 ident: BFnature09229_CR11 publication-title: Nature doi: 10.1038/nature718 – volume: 37 start-page: 879 year: 1984 ident: BFnature09229_CR31 publication-title: Cell doi: 10.1016/0092-8674(84)90423-9 – volume: 98 start-page: 427 year: 1984 ident: BFnature09229_CR34 publication-title: J. Cell Biol. doi: 10.1083/jcb.98.2.427 – volume: 61 start-page: 1213 year: 1992 ident: BFnature09229_CR89 publication-title: Annu. Rev.Biochem. doi: 10.1146/annurev.bi.61.070192.010025 – volume: 407 start-page: 318 year: 2000 ident: BFnature09229_CR91 publication-title: Nature doi: 10.1038/35030301 – volume: 460 start-page: 1145 year: 2009 ident: BFnature09229_CR72 publication-title: Nature doi: 10.1038/nature08285 – volume: 394 start-page: 369 year: 1998 ident: BFnature09229_CR10 publication-title: Nature doi: 10.1038/28615 – volume: 279 start-page: 525 year: 2005 ident: BFnature09229_CR94 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2005.01.016 – volume: 10 start-page: 575 year: 2008 ident: BFnature09229_CR37 publication-title: Nature Cell Biol. doi: 10.1038/ncb1720 – volume: 290 start-page: 1578 year: 2000 ident: BFnature09229_CR93 publication-title: Science doi: 10.1126/science.290.5496.1578 – volume: 458 start-page: 766 year: 2009 ident: BFnature09229_CR78 publication-title: Nature doi: 10.1038/nature07863 – volume: 447 start-page: 679 year: 2007 ident: BFnature09229_CR13 publication-title: Nature doi: 10.1038/nature05879 – volume: 319 start-page: 1827 year: 2008 ident: BFnature09229_CR19 publication-title: Science doi: 10.1126/science.1153069 – volume: 325 start-page: 816 year: 1987 ident: BFnature09229_CR47 publication-title: Nature doi: 10.1038/325816a0 – volume: 449 start-page: 473 year: 2007 ident: BFnature09229_CR52 publication-title: Nature doi: 10.1038/nature06159 – volume: 78 start-page: 7634 year: 1981 ident: BFnature09229_CR2 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.78.12.7634 – volume: 17 start-page: 771 year: 1979 ident: BFnature09229_CR50 publication-title: Cell doi: 10.1016/0092-8674(79)90317-9 – volume: 385 start-page: 810 year: 1997 ident: BFnature09229_CR9 publication-title: Nature doi: 10.1038/385810a0 – volume: 56 start-page: 1437 year: 1966 ident: BFnature09229_CR23 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.56.5.1437 – volume: 460 start-page: 1136 year: 2009 ident: BFnature09229_CR70 publication-title: Nature doi: 10.1038/nature08290 – volume: 26 start-page: 1276 year: 2008 ident: BFnature09229_CR65 publication-title: Nature Biotechnol. doi: 10.1038/nbt.1503 – volume: 318 start-page: 1917 year: 2007 ident: BFnature09229_CR66 publication-title: Science doi: 10.1126/science.1151526 – volume: 463 start-page: 1035 year: 2010 ident: BFnature09229_CR82 publication-title: Nature doi: 10.1038/nature08797 – volume: 27 start-page: 459 year: 2009 ident: BFnature09229_CR75 publication-title: Nature Biotechnol. doi: 10.1038/nbt.1535 – volume: 26 start-page: 101 year: 2008 ident: BFnature09229_CR61 publication-title: Nature Biotechnol. doi: 10.1038/nbt1374 – volume: 2 start-page: 330 year: 1988 ident: BFnature09229_CR32 publication-title: Genes Dev. doi: 10.1101/gad.2.3.330 – volume: 46 start-page: 591 year: 1986 ident: BFnature09229_CR35 publication-title: Cell doi: 10.1016/0092-8674(86)90885-8 – volume: 26 start-page: 916 year: 2008 ident: BFnature09229_CR77 publication-title: Nature Biotechnol. doi: 10.1038/nbt1483 – volume: 223 start-page: 363 year: 1969 ident: BFnature09229_CR26 publication-title: Nature doi: 10.1038/223363a0 – volume: 104 start-page: 4395 year: 2007 ident: BFnature09229_CR84 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0700181104 – volume: 6 start-page: 984 year: 2004 ident: BFnature09229_CR18 publication-title: Nature Cell Biol. doi: 10.1038/ncb1176 – volume: 4 start-page: 256 year: 1962 ident: BFnature09229_CR8 publication-title: Dev. Biol. doi: 10.1016/0012-1606(62)90043-X – volume: 23 start-page: 1431 year: 2009 ident: BFnature09229_CR83 publication-title: FASEB J. doi: 10.1096/fj.08-122903 – volume: 292 start-page: 154 year: 1981 ident: BFnature09229_CR1 publication-title: Nature doi: 10.1038/292154a0 – volume: 105 start-page: 17318 year: 2008 ident: BFnature09229_CR15 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0806166105 – volume: 460 start-page: 1132 year: 2009 ident: BFnature09229_CR74 publication-title: Nature doi: 10.1038/nature08235 – volume: 428 start-page: 44 year: 2004 ident: BFnature09229_CR12 publication-title: Nature doi: 10.1038/nature02375 – volume: 112 start-page: 781 year: 1991 ident: BFnature09229_CR22 publication-title: J. Cell Biol. doi: 10.1083/jcb.112.5.781 – volume: 1 start-page: 1 year: 1966 ident: BFnature09229_CR29 publication-title: J. Cell Sci. doi: 10.1242/jcs.1.1.1 – volume: 463 start-page: 1042 year: 2010 ident: BFnature09229_CR45 publication-title: Nature doi: 10.1038/nature08752 – volume: 460 start-page: 49 year: 2009 ident: BFnature09229_CR80 publication-title: Nature doi: 10.1038/nature08180 – volume: 3 start-page: 318 year: 1961 ident: BFnature09229_CR87 publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(61)80072-7 – volume: 131 start-page: 861 year: 2007 ident: BFnature09229_CR63 publication-title: Cell doi: 10.1016/j.cell.2007.11.019 – volume: 41 start-page: 968 year: 2009 ident: BFnature09229_CR76 publication-title: Nature Genet. doi: 10.1038/ng.428 – volume: 448 start-page: 318 year: 2007 ident: BFnature09229_CR59 publication-title: Nature doi: 10.1038/nature05944 – volume-title: A Genetic Switch: Gene Control and Phage Lambda year: 1986 ident: BFnature09229_CR88 – volume: 68 start-page: 3026 year: 1971 ident: BFnature09229_CR24 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.68.12.3026 – volume: 16 start-page: 6510 year: 1997 ident: BFnature09229_CR39 publication-title: EMBO J. doi: 10.1093/emboj/16.21.6510 – volume: 126 start-page: 663 year: 2006 ident: BFnature09229_CR56 publication-title: Cell doi: 10.1016/j.cell.2006.07.024 – volume: 69 start-page: 571 year: 1972 ident: BFnature09229_CR27 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.69.3.571 – volume: 2 start-page: 10 year: 2008 ident: BFnature09229_CR62 publication-title: Cell Stem Cell doi: 10.1016/j.stem.2007.12.001 – volume: 100 start-page: 2088 year: 2003 ident: BFnature09229_CR38 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0337659100
SSID	ssj0005174
Score	2.5441267
SecondaryResourceType	review_article
Snippet	The stable states of differentiated cells are now known to be controlled by dynamic mechanisms that can easily be perturbed. An adult cell can therefore be...
SourceID	pubmedcentral proquest gale pubmed crossref springer
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	704
SubjectTerms	631/136/2444 631/136/532/2064 631/136/532/2435 631/1647/1513 Amphibians - embryology Animals Cell Fusion Cellular Reprogramming - genetics Cellular Reprogramming - physiology Deoxyribonucleic acid DNA DNA methylation Embryonic development Embryonic stem cells Gene expression Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Mammals multidisciplinary Nuclear Transfer Techniques review-article Science Science (multidisciplinary) Stem cells Studies Transcription Factors - genetics Transcription Factors - metabolism Transduction, Genetic
Title	Nuclear reprogramming to a pluripotent state by three approaches
URI	https://link.springer.com/article/10.1038/nature09229 https://www.ncbi.nlm.nih.gov/pubmed/20535199 https://www.proquest.com/docview/518151515 https://www.proquest.com/docview/733261693 https://pubmed.ncbi.nlm.nih.gov/PMC2901154
Volume	465
WOSCitedRecordID	wos000278551800032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAQT databaseName: Nature customDbUrl: eissn: 1476-4687 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: RNT dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.nature.com providerName: Nature Publishing – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: P5Z dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M0K dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7P dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Earth, Atmospheric & Aquatic Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PCBAR dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/eaasdb providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M7S dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: PATMY dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7X7 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: KB. dateStart: 19880107 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 7RV dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: BENPR dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Psychology Database (ProQuest) customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2M dateStart: 19880107 isFulltext: true titleUrlDefault: https://www.proquest.com/psychology providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: 8C1 dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Research Library customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2O dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/pqrl providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1476-4687 dateEnd: 20241212 omitProxy: false ssIdentifier: ssj0005174 issn: 0028-0836 databaseCode: M2P dateStart: 19880107 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bb9MwFLbYBhIvwMYtbFQWGlcpLHc7T7BNm0CjpdoGqniJXMcelUbSNSkS_55zHPeSquIFRTpS5JPEic9N8efPhOwjw4rkHneHkJ_dSEapm8aRcnmci8DTvhS-WSj8hfV6fDBI-xabU1lY5SwmmkCdlxL_kR_EkIpiPD6Mb1zcNAonV-0OGhtkC-pkjn7ZDboLhMcKCbNdnueF_KBhzfTSwJSWi4S0GpaX8tIqZnJl4tTko9P7__kmD8g9W4jSw8ZytsktVeyQOwYQKqsdsm2dvqJvLDP124fkYw_Zj8WEIhWmwXX9gr7RuqSCjq-nEH9KKMFralYp0eEfWoOlKDrjLVfVI_Lt9OTy-JNrt2BwZcKS2tVSMxXFea6jSCdCqDSHEiXKhR9I4alQBVLLgA2DXCUKYm7KfPw1GkZepKFy0-FjslmUhXpKqB56SqQylSEHzUSK2JeBr8IkHIbaF8wh72bjkEnLT47bZFxnZp485NnSoDlkf648bmg51qu9wAHNkOiiQCTNlZhWVfb54jw7NET3HLKxQ15bJV3CA6WwCxOg28iN1dLcbWnK8egmW2p91Wq9akZn3W32Worg0LL9lJndZDagVNncaBxC5614IWLkClVOq4yFUIojt45DnjS2Ov80AbL4-Hhr1rLiuQKSjLdbitFPQzaO8-zgxg55ObP3RafWfPFn_-z8LrnboC8SSP97ZLOeTNVzclv-rkfVpEM22Pl3lANmJAfJj_0O2To66fXP4ezs6D3IrnfWMZ5u5Fcj-yhZIy9A9uMffwGWG1p8
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwFD4aAwQvwMYtbICFNi6ToiXO_QHBBEyrVgoaQ9qb5zj2qDSSrklB-1H8R3ycpG2qirc9oDz6xHHsc3Pync8AW8iwImIntlMdn21f-ImdBL604yDj1FGu4K4pFO5Hg0F8cpJ8XYE_bS0Mwipbn2gcdVYI_Ea-G-hQFOD1bnRh46FR-HO1PUGj1opDeflb79jKt72Penm3Kd3_dPzhwG4OFbBFGIWVrYSKpB9kmfJ9FXIuk0wHXT_jLhXckZ6kQgkapTSTodReJIlc_Njn-Y6vdC6iPN3vNbju40YIkYL0ywxRskD63JQDOl68W7N0Ogk1qewsAC6Ggbk4uIjRXPhRa-Lf_t3_bObuwZ0m0SZ7tWWswYrM1-GmAbyKch3WGqdWktcN8_ab-_B-gOzOfEyQ6tPg1n7quSBVQTgZnU-0fy30FqMipgqLpJek0pYgScvLLssH8P1K3ukhrOZFLh8DUakjeSIS4cVaMhQ8cAV1pRd6qadcHlmw0647Ew3_Oh4Dcs4MDsCL2ZySWLA1FR7VtCPLxV6gAjEk8sgRKXTGJ2XJet-O2J4h8o91tmHBq0ZIFfqBgjeFF3rYyP3VkdzoSIrR8ILNtb7stJ7Vq7Osm82OoHZYovuUVk9Z4zBLNlVSC8i0FW9EDGAui0nJIk9vNZA7yIJHtW1Mp4YiS5GLXUcdq5kKIIl6tyUf_jBk6ogj0G7Kgu3WvmaDWjLjT_45-Odw6-D4c5_1e4PDDbhdI01Cnepswmo1nsincEP8qobl-JnxHAROr9rg_gIr4a0F
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9NAFH4qZREXoGUzLTBCLZtkxftyQFBRIqJWUcQiVVyG8XimRCp2Gjug_jT-He95SeIo4tYD8nGex-OZt439vW8A9ohhRUZWZCYYn01PerEZ-54yIz8VjqVtKeyqUPg4HA6jk5N4tAF_2loYglW2PrFy1Gku6Rt5z8dQ5NPV0w0qYnTYfzs5N-kAKfrR2p6mUWvIkbr4jbu34s3gEJd633H6H768_2g2BwyYMgiD0tRSh8rz01R7ng6EUHGKAdhLhe1IYSlXOVJLJ0ycVAUKPUoc2vThz_UsT2Neol3s9wpcDXGLSWjCkf9tgS5ZIYBuSgMtN-rVjJ1W7FRp7SIYroaEpZi4itdc-WlbxcL-7f94Fu_ArSYBZwe1xWzBhsq24XoFhJXFNmw1zq5gLxtG7ld34d2QWJ_FlBEFaIVn-4nzwsqcCTY5m6HfzXHrUbKqOoslF6xEC1Gs5WtXxT34einvdB82szxTD4HpxFIilrF0I5QMpPBt6djKDdzE1bYIDXjd6gCXDS87HQ9yxit8gBvxJYUxYG8uPKnpSNaLPSNl4kTwkdEqn4pZUfDB50_8oCL4jzALMeBFI6RzfKAUTUEGDps4wTqSOx1JORmf86XW553W03p11nWz2xFERya7T2l1ljeOtOBzhTWAzVvpRsIGZiqfFTx0cQtCnEIGPKjtZD41DrEX2dR12LGguQCRq3dbsvGPimSd8AXovgzYb21tMag1M_7on4N_CjfQzvjxYHi0AzdrAEqAGdAubJbTmXoM1-SvclxMn1ROhMH3y7a3v7YTtfQ
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nuclear+reprogramming+to+a+pluripotent+state+by+three+approaches&rft.jtitle=Nature+%28London%29&rft.au=Yamanaka%2C+Shinya&rft.au=Blau%2C+Helen+M&rft.date=2010-06-10&rft.pub=Nature+Publishing+Group&rft.issn=0028-0836&rft.volume=465&rft.issue=7299&rft.spage=704&rft_id=info:doi/10.1038%2Fnature09229&rft.externalDocID=A229068299
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0028-0836&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0028-0836&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0028-0836&client=summon