Management of severe acute exacerbations of COPD: an updated narrative review
Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status wit...
Uložené v:
| Vydané v: | Multidisciplinary respiratory medicine Ročník 13; číslo 1; s. 36 - 15 |
|---|---|
| Hlavní autori: | , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
BioMed Central
02.10.2018
BioMed Central Ltd PAGEPress Publications Mattioli 1885 |
| Predmet: | |
| ISSN: | 2049-6958, 1828-695X, 2049-6958 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background
Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital.
Main body
In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD.
Conclusion
Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. |
|---|---|
| AbstractList | Abstract Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. Main body In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Conclusion Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. Main body In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Conclusion Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. Keywords: COPD, Acute exacerbation, Hospitalization, Steroids, Antibiotics, Oxygen, High flow nasal cannulae oxygen therapy, Non-invasive mechanical ventilation, Pulmonary rehabilitation Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. Main body In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Conclusion Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital.BACKGROUNDPatients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital.In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD.MAIN BODYIn this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD.Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs.CONCLUSIONSeveral treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. Background: Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. Main body: In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Conclusion: Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this event is defined as a COPD exacerbation (AECOPD). Hospitalization for AECOPD is accompanied by a rapid decline in health status with a high risk of mortality or other negative outcomes such as need for endotracheal intubation or intensive care unit (ICU) admission. Treatments for AECOPD aim to minimize the negative impact of the current exacerbation and to prevent subsequent events, such as relapse or readmission to hospital. In this narrative review, we update the scientific evidence about the in-hospital pharmacological and non-pharmacological treatments used in the management of a severe AECOPD. We review inhaled bronchodilators, steroids, and antibiotics for the pharmacological approach, and oxygen, high flow nasal cannulae (HFNC) oxygen therapy, non-invasive mechanical ventilation (NIMV) and pulmonary rehabilitation (PR) as non-pharmacological treatments. We also review some studies of non-conventional drugs that have been proposed for severe AECOPD. Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. Main body Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a hypercapnic acute respiratory failure and respiratory acidosis) are supported by strong evidence of their efficacy. HFNC oxygen therapy needs further prospective studies. Although antibiotics are preferred in ICU patients, there is a lack of evidence regarding the preferred drugs and optimal duration of treatment for non-ICU patients. Early rehabilitation, if associated with standard treatment of patients, is recommended due to its feasibility and safety. There are currently few promising new drugs or new applications of existing drugs. |
| ArticleNumber | 36 |
| Audience | Academic |
| Author | Crisafulli, Ernesto Barbeta, Enric Ielpo, Antonella Torres, Antoni |
| Author_xml | – sequence: 1 givenname: Ernesto surname: Crisafulli fullname: Crisafulli, Ernesto organization: Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma – sequence: 2 givenname: Enric surname: Barbeta fullname: Barbeta, Enric organization: Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona – sequence: 3 givenname: Antonella surname: Ielpo fullname: Ielpo, Antonella organization: Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma – sequence: 4 givenname: Antoni surname: Torres fullname: Torres, Antoni email: ATORRES@clinic.cat organization: Pneumology Department, Clinic Institute of Thorax, Hospital Clinic of Barcelona - Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30302247$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Ul1v0zAUjdAQG2U_gBcUCQnx0uFvuzwgTeVr0qbxAM-W61y3rlK72EmBf4_Tjq6dgFhWbN9zznVOztPqJMQAVfUcowuMlXiTGSJMjREeJpuM0aPqjKCyEBOuTg7Wp9V5zktUHsEx5exJdUoRRYQweVbd3Jhg5rCC0NXR1Rk2kKA2tu-ghp_GQpqZzseQh-r09sv7t7UJdb9uTAdNHUxKpbyBOsHGw49n1WNn2gznd-9R9e3jh6_Tz-Pr209X08vrsRVSdGNHG0ImjbTYSASNsAI11jBGDLXEIaUcFhYUUkxIzjBhDhA2BjAoy5Gb0FF1tdNtolnqdfIrk37paLzeHsQ01yZ13raglUV4JqxrRHFJNDMFlhnaUOo45RMsita7nda6n62gscWJZNoj0eNK8As9jxstsJBSqSKAdwI291YnKJ5Z022J-80wCZJEUy4wR4Xz-q5pit97yJ1e-WyhbU2A2GdNMJaKUFJ-2Kh6-QC6jH0Kxd6CIoRgpoS8R81N-WgfXCx3tYOovuRcCsEVHdpe_AVVRgMrb0u-nC_nR4RXB4QFmLZb5Nj220gcA18curi370_SDlxKMecEbg_BSA-B1rtA6xJoPQRaD6LyAcf6bhvHcm3f_pdJdsxcuoQ5pHvT_k36DQFCBWE |
| CitedBy_id | crossref_primary_10_1097_NJH_0000000000000858 crossref_primary_10_1111_crj_13251 crossref_primary_10_1007_s00223_019_00591_4 crossref_primary_10_3389_fmed_2020_595450 crossref_primary_10_1371_journal_pone_0256866 crossref_primary_10_1097_MD_0000000000037792 crossref_primary_10_1016_j_jiac_2019_03_018 crossref_primary_10_2147_COPD_S436326 crossref_primary_10_1007_s11739_020_02420_1 crossref_primary_10_3390_jcm12103369 crossref_primary_10_1097_01_JAA_0000944636_06231_f0 crossref_primary_10_3390_ijerph18189905 crossref_primary_10_1080_17520363_2025_2548189 crossref_primary_10_1016_j_jemermed_2020_07_001 crossref_primary_10_1183_23120541_00188_2020 crossref_primary_10_3390_jcm12186106 crossref_primary_10_1080_00325481_2021_2018257 crossref_primary_10_5005_jp_journals_10071_24806 crossref_primary_10_1016_j_rmed_2024_107661 crossref_primary_10_3390_antibiotics11111577 crossref_primary_10_2196_16343 crossref_primary_10_1183_23120541_00194_2023 crossref_primary_10_1007_s00405_020_06521_7 crossref_primary_10_12998_wjcc_v11_i26_6040 crossref_primary_10_7759_cureus_79288 crossref_primary_10_1016_j_vaccine_2022_08_053 crossref_primary_10_2147_COPD_S512096 crossref_primary_10_1055_s_0040_1702196 crossref_primary_10_1016_j_arbr_2019_03_021 crossref_primary_10_1016_j_chemosphere_2020_128905 crossref_primary_10_1186_s12890_023_02635_w crossref_primary_10_2147_COPD_S477268 crossref_primary_10_1080_17476348_2020_1732823 crossref_primary_10_1177_14799731221140797 crossref_primary_10_3390_jpm12020299 crossref_primary_10_3390_toxics10110667 crossref_primary_10_2147_COPD_S444888 crossref_primary_10_3390_ijms20184329 crossref_primary_10_1016_j_chest_2023_07_021 crossref_primary_10_1080_17476348_2019_1635459 crossref_primary_10_1055_s_0040_1709139 crossref_primary_10_1097_CCM_0000000000005807 crossref_primary_10_1016_j_emc_2022_05_007 crossref_primary_10_3390_medicina61071288 crossref_primary_10_3390_clinpract14060180 crossref_primary_10_1016_j_arbres_2019_03_009 crossref_primary_10_1063_5_0189452 crossref_primary_10_1055_a_2693_0577 crossref_primary_10_1111_crj_13409 crossref_primary_10_1186_s12873_025_01267_z crossref_primary_10_1186_s12931_020_1328_z crossref_primary_10_1155_2022_4457740 crossref_primary_10_1155_carj_3647362 crossref_primary_10_7759_cureus_43694 crossref_primary_10_1080_15412555_2022_2029834 crossref_primary_10_1016_j_advms_2023_04_001 crossref_primary_10_1080_17476348_2024_2375426 crossref_primary_10_1016_j_rmed_2023_107425 crossref_primary_10_1186_s12890_020_1083_4 crossref_primary_10_2147_COPD_S418162 |
| Cites_doi | 10.1016/j.jcrc.2011.07.075 10.1136/bmj.c5462 10.1016/j.jcrc.2008.08.007 10.1016/0140-6736(93)90696-E 10.2147/COPD.S153631 10.2147/COPD.S145253 10.1016/j.pupt.2013.03.020 10.1111/crj.12772 10.1164/ajrccm.151.6.7767523 10.1159/000324259 10.1016/0007-0971(72)90016-2 10.1007/s00134-011-2354-6 10.1164/ajrccm.157.5.9711044 10.1136/bmj.2.5607.735 10.1136/bmj.326.7382.185 10.1016/j.rmed.2012.05.005 10.1136/thorax.56.9.708 10.1007/s11739-011-0727-z 10.1016/j.rmed.2003.09.001 10.1371/journal.pone.0191243 10.1086/653527 10.1001/archinte.1997.00440360162018 10.1378/chest.114.6.1636 10.1136/thx.47.1.34 10.1164/rccm.201001-0054ED 10.1016/j.rmed.2016.10.013 10.1513/AnnalsATS.201310-358OC 10.1183/13993003.00426-2016 10.1186/1471-2466-14-98 10.1136/thx.2007.086371 10.1183/09031936.00053814 10.1016/j.ejim.2014.01.003 10.1183/09031936.00002913 10.1183/13993003.02426-2016 10.1016/S0140-6736(01)07097-0 10.1136/bmj.g4315 10.1183/09031936.00042111 10.1164/rccm.200906-0837OC 10.1002/14651858.CD010172.pub2. 10.1016/S0924-8579(01)00435-6 10.1378/chest.10-3058 10.1164/ajrccm.161.4.9904065 10.1016/j.pupt.2016.01.002 10.1136/bmj.326.7396.956 10.1097/CPM.0000000000000090 10.1164/ajrccm.165.5.2109093 10.1183/09031936.02.00287402 10.7326/0003-4819-106-2-196 10.1016/j.pupt.2013.03.004 10.1001/jama.2013.5023 10.1513/AnnalsATS.201308-254OC 10.1183/13993003.00791-2016 10.1186/s12890-017-0486-3 10.1111/j.1440-1843.2008.01418.x 10.1164/rccm.200908-1203OC 10.5603/ARM.27674 10.1056/NEJM199906243402502 10.1378/chest.06-1500 10.4187/respcare.03036 10.1186/cc10567 10.1056/NEJMoa023161 10.1136/thorax.58.1.73 10.3109/15412555.2010.540273 10.1371/journal.pone.0158727 10.1378/chest.15-1504 10.1097/HCR.0b013e3181ac7bb8 10.1183/09031936.00203809 10.1183/09031936.00088611 10.12659/MSM.895027 10.1016/j.rmed.2013.10.022 10.1080/15412555.2016.1209476 10.1183/13993003.01312-2017 10.4187/respcare.04597 10.1183/09031936.00109906 10.1016/S0140-6736(00)02323-0 10.2146/ajhp160979 10.1378/chest.07-0208 10.2147/COPD.S115581 10.1016/S0140-6736(07)61382-8 10.1016/S1094-5539(03)00025-7 10.1136/thx.50.7.755 10.1164/rccm.201610-2102ED 10.1164/rccm.201401-0058OC 10.1016/j.pupt.2017.12.007 10.4187/respcare.03009 10.1001/jama.2010.796 10.1136/thx.2010.152876 10.1378/chest.119.3.726 10.1016/j.rmed.2016.05.003 10.1016/S0140-6736(98)11326-0 10.2147/COPD.S112820 10.1183/09031936.05.00085304 10.3109/15412555.2014.933954 10.1371/journal.pone.0150737 10.1164/rccm.201106-1094OC 10.1186/s13613-017-0273-6 10.1183/13993003.01432-2017 10.1183/09031936.00043710 10.1164/rccm.201309-1634ST 10.1056/NEJMoa0909883 10.1111/resp.13050 10.1136/thorax.55.7.550 10.1007/s11255-016-1272-5 10.1002/pri.1541 10.1378/chest.14-0655 10.21037/atm.2017.06.52 10.1001/jama.2009.1297 10.2147/COPD.S85831 10.4187/respcare.02086 10.1164/rccm.201601-0083OC 10.1097/CCM.0b013e3181b78abe 10.1016/j.rmed.2009.04.011 10.1186/s13054-018-2033-x 10.1016/S0140-6736(09)60496-7 10.3109/15412555.2015.1101435 10.1164/rccm.200604-506OC 10.1159/000192773 10.1016/j.rmed.2017.08.005 10.1586/erp.13.9 10.1186/2049-6958-5-3-202 10.1136/thoraxjnl-2011-201518 10.3390/medsci6020050 10.2147/COPD.S104616 10.1136/thx.2003.008730 10.1136/thoraxjnl-2016-208460 10.1183/09031936.00112909 10.1056/NEJMra0800353 10.1016/j.apmr.2014.05.007 10.1186/s12931-018-0820-1 10.1111/crj.12942 10.1157/13091646 10.1056/NEJMoa1516385 10.3109/15412555.2015.1057276 10.1164/ajrccm.161.3.9808143 10.1097/HCR.0b013e318252f0b2 10.1136/thx.2010.153114 10.1183/13993003.00075-2017 10.5588/ijtld.10.0540 10.4187/respcare.02160 10.1001/archinternmed.2011.530 10.1016/j.ijid.2016.04.024 10.1056/NEJM199509283331301 10.1378/chest.13-0488 10.1513/AnnalsATS.201208-043OC 10.1136/thorax.58.9.752 10.1136/thorax.58.7.589 |
| ContentType | Journal Article |
| Contributor | Universitat de Barcelona |
| Contributor_xml | – sequence: 1 fullname: Universitat de Barcelona |
| Copyright | The Author(s). 2018 COPYRIGHT 2018 BioMed Central Ltd. Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. cc-by (c) Crisafulli, Ernesto et al., 2018 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/3.0/es |
| Copyright_xml | – notice: The Author(s). 2018 – notice: COPYRIGHT 2018 BioMed Central Ltd. – notice: Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: cc-by (c) Crisafulli, Ernesto et al., 2018 info:eu-repo/semantics/openAccess <a href="http://creativecommons.org/licenses/by/3.0/es">http://creativecommons.org/licenses/by/3.0/es</a> |
| DBID | C6C AAYXX CITATION NPM 3V. 7X7 7XB 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH K9. M0S PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 XX2 5PM DOA |
| DOI | 10.1186/s40248-018-0149-0 |
| DatabaseName | SpringerOpen Free (Free internet resource, activated by CARLI) CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic Recercat PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest One Health & Nursing ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete ProQuest Health & Medical Research Collection Health Research Premium Collection ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest Central Korea ProQuest Central (New) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed Publicly Available Content Database |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database (ProQuest) url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 2049-6958 |
| EndPage | 15 |
| ExternalDocumentID | oai_doaj_org_article_8c01b6cfd60146db8ec4a3d33f535916 PMC6167788 oai_recercat_cat_2072_356150 A557665830 30302247 10_1186_s40248_018_0149_0 |
| Genre | Journal Article Review |
| GroupedDBID | --- 123 4.4 53G 5VS 7X7 8FI 8FJ AAFWJ ABDBF ABUWG ACGFS ACUHS ADBBV ADRAZ ADUKV AFKRA AFPKN AHBYD AHMBA AHYZX ALMA_UNASSIGNED_HOLDINGS AMKLP AOIJS BAWUL BCNDV BENPR BFQNJ BMC BPHCQ BVXVI C6C CCPQU DIK EBS EJD FYUFA GROUPED_DOAJ H13 HMCUK HYE IAO IHR IHW INH INR ITC KQ8 M48 OK1 PGMZT PHGZM PHGZT PIMPY PQQKQ PROAC PUEGO RBZ RNS ROL RPM RSV SOJ UKHRP AAYXX AFFHD CITATION AHSBF ALIPV IPNFZ NPM RIG 3V. 7XB 8FK AZQEC DWQXO K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8 XX2 5PM |
| ID | FETCH-LOGICAL-c676t-f3d229d7c1a70ed6c60dca442a3c2f088f16ce80846754124fe01aae1e8c50f93 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 69 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000446483100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2049-6958 1828-695X |
| IngestDate | Tue Oct 14 18:04:33 EDT 2025 Tue Nov 04 01:58:31 EST 2025 Fri Nov 07 13:52:52 EST 2025 Sun Nov 09 11:34:53 EST 2025 Tue Oct 07 07:01:23 EDT 2025 Tue Nov 11 10:14:04 EST 2025 Tue Nov 04 17:24:50 EST 2025 Thu May 22 21:19:58 EDT 2025 Thu Apr 03 07:06:40 EDT 2025 Tue Nov 18 20:57:45 EST 2025 Sat Nov 29 05:55:43 EST 2025 Sat Sep 06 07:26:34 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Oxygen Antibiotics Hospitalization Acute exacerbation Non-invasive mechanical ventilation Pulmonary rehabilitation High flow nasal cannulae oxygen therapy COPD Steroids |
| Language | English |
| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c676t-f3d229d7c1a70ed6c60dca442a3c2f088f16ce80846754124fe01aae1e8c50f93 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://doaj.org/article/8c01b6cfd60146db8ec4a3d33f535916 |
| PMID | 30302247 |
| PQID | 2122214867 |
| PQPubID | 2040200 |
| PageCount | 15 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_8c01b6cfd60146db8ec4a3d33f535916 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6167788 csuc_recercat_oai_recercat_cat_2072_356150 proquest_miscellaneous_2117823251 proquest_journals_2122214867 gale_infotracmisc_A557665830 gale_infotracacademiconefile_A557665830 gale_healthsolutions_A557665830 pubmed_primary_30302247 crossref_primary_10_1186_s40248_018_0149_0 crossref_citationtrail_10_1186_s40248_018_0149_0 springer_journals_10_1186_s40248_018_0149_0 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-10-02 |
| PublicationDateYYYYMMDD | 2018-10-02 |
| PublicationDate_xml | – month: 10 year: 2018 text: 2018-10-02 day: 02 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: Italy – name: Pavia |
| PublicationTitle | Multidisciplinary respiratory medicine |
| PublicationTitleAbbrev | Multidiscip Respir Med |
| PublicationTitleAlternate | Multidiscip Respir Med |
| PublicationYear | 2018 |
| Publisher | BioMed Central BioMed Central Ltd PAGEPress Publications Mattioli 1885 |
| Publisher_xml | – name: BioMed Central – name: BioMed Central Ltd – name: PAGEPress Publications – name: Mattioli 1885 |
| References | B Sztrymf (149_CR87) 2011; 37 A Pines (149_CR79) 1968; 2 SM Maggiore (149_CR123) 2010; 38 JR Hurst (149_CR3) 2006; 174 Y Ceviker (149_CR57) 2014; 27 SD Aaron (149_CR50) 2003; 348 MA Spruit (149_CR129) 2013; 188 SM Lin (149_CR90) 2017; 131 M Mantero (149_CR29) 2017; 12 Z Jiang (149_CR64) 2016; 37 M Santibáñez (149_CR20) 2016; 11 PK Plant (149_CR84) 2000; 55 P Schuetz (149_CR72) 2009; 302 NR Anthonisen (149_CR8) 1987; 106 E Crisafulli (149_CR37) 2016; 13 AN Amin (149_CR39) 2018; 75 A Segreti (149_CR46) 2013; 26 JV Lightowler (149_CR106) 2003; 326 I Vogiatzis (149_CR139) 2010; 36 L Brochard (149_CR99) 1995; 333 A Sayiner (149_CR60) 2001; 119 A Corley (149_CR91) 2017; 5 S Nouira (149_CR77) 2001; 358 S Nava (149_CR114) 2009; 54 A Singanayagam (149_CR21) 2013; 10 MO Turner (149_CR40) 1997; 157 S Suissa (149_CR5) 2012; 67 B Sztrymf (149_CR88) 2012; 27 JL Alonso Martínez (149_CR78) 1992; 9 M Sadatsafavi (149_CR17) 2018; 13 M Maddocks (149_CR138) 2016; 71 CY Tang (149_CR146) 2012; 32 H Vogelsinger (149_CR92) 2017; 17 V Prieto-Centurion (149_CR30) 2014; 11 A Huerta (149_CR68) 2013; 144 F Lellouche (149_CR85) 2016; 11 M Miravitlles (149_CR152) 2004; 59 149_CR1 AI Papaioannou (149_CR42) 2018; 48 M Miravitlles (149_CR67) 2012; 39 E Crisafulli (149_CR33) 2015; 22 E Crisafulli (149_CR35) 2016; 48 S Nava (149_CR113) 2009; 374 T Celikel (149_CR100) 1998; 114 149_CR127 R Pauwels (149_CR6) 2004; 98 149_CR128 F Maltais (149_CR62) 2002; 165 J Bräunlich (149_CR93) 2016; 11 A Marchioni (149_CR126) 2018; 22 V Antonaglia (149_CR116) 2011; 82 C Estirado (149_CR70) 2018; 19 EM Clini (149_CR140) 2009; 103 M Aliyali (149_CR26) 2015; 14 RC Borges (149_CR142) 2014; 95 R Sharif (149_CR31) 2014; 11 M He (149_CR145) 2015; 21 J Bott (149_CR109) 1993; 341 T Troosters (149_CR141) 2010; 181 EJ Chaplin (149_CR154) 2013; 18 JM Daniels (149_CR81) 2010; 181 Maria Montes de Oca (149_CR7) 2018; 6 H Kilic (149_CR16) 2015; 10 I Torres-Sánchez (149_CR143) 2017; 14 EM Clini (149_CR130) 2009; 77 J Bourbeau (149_CR44) 2016; 13 PM Calverley (149_CR36) 2018; 13 JA Wedzicha (149_CR47) 2016; 374 Z Ding (149_CR63) 2016; 121 J Abreu González (149_CR159) 2006; 42 149_CR9 YP de Jong (149_CR53) 2007; 132 A Nicolini (149_CR117) 2014; 59 SA Antoniu (149_CR14) 2013; 13 E Crisafulli (149_CR131) 2010; 5 F Di Marco (149_CR118) 2011; 15 M Cazzola (149_CR43) 2003; 16 149_CR96 S Sethi (149_CR65) 2008; 359 E Crisafulli (149_CR61) 2014; 59 E Crisafulli (149_CR134) 2014; 9 MA Spruit (149_CR157) 2018; 51 AA Jeffrey (149_CR98) 1992; 47 D Stolz (149_CR71) 2007; 131 PK Lindenauer (149_CR58) 2010; 303 E Crisafulli (149_CR136) 2008; 63 E Clini (149_CR147) 2011; 79 E Clini (149_CR153) 2010; 181 TJ Martin (149_CR103) 2000; 161 P Jolliet (149_CR120) 2017; 195 BR Celli (149_CR13) 2007; 29 N Ambrosino (149_CR124) 1995; 50 SJ Carr (149_CR151) 2009; 29 JR Hurst (149_CR18) 2010; 363 JD Leuppi (149_CR52) 2013; 309 MA Spruit (149_CR150) 2003; 58 JA Wedzicha (149_CR66) 2007; 370 RG Masterton (149_CR75) 2001; 18 PK Plant (149_CR112) 2003; 326 S Nouira (149_CR82) 2010; 51 F Thys (149_CR101) 2002; 20 F Abroug (149_CR56) 2014; 43 MA Austin (149_CR83) 2010; 341 J Garcia-Aymerich (149_CR15) 2011; 66 S Spencer (149_CR4) 2003; 58 JW Kocks (149_CR38) 2013; 8 R Chalela (149_CR24) 2016; 117 S Giavedoni (149_CR155) 2012; 106 E Crisafulli (149_CR137) 2010; 36 M Hoogendoorn (149_CR23) 2011; 37 CM Roberts (149_CR97) 2011; 66 WH van Geffen (149_CR41) 2016; 8 CR Osadnik (149_CR107) 2017; 7 J Riera (149_CR89) 2013; 58 R Garrod (149_CR132) 2011; 38 E Crisafulli (149_CR32) 2015; 12 L Davies (149_CR48) 1999; 354 N Soler (149_CR69) 1998; 157 M Ferrer (149_CR122) 2017; 195 S Jaber (149_CR119) 2000; 161 JX Wang (149_CR74) 2016; 48 E Crisafulli (149_CR135) 2014; 25 AD Alahmari (149_CR148) 2014; 14 NJ Greening (149_CR156) 2014; 349 JM Wells (149_CR28) 2016; 149 PG Woodruff (149_CR160) 2011; 8 F Fabbian (149_CR27) 2016; 48 F Abroug (149_CR121) 2017; 7 JP Frat (149_CR86) 2017; 5 Bram Rochwerg (149_CR105) 2017; 50 Guillaume Noell (149_CR11) 2017; 50 P Aggarwal (149_CR54) 2011; 15 I Alía (149_CR51) 2011; 171 L Pisani (149_CR115) 2015; 45 MK Lee (149_CR95) 2018; 12 A Pines (149_CR80) 1972; 66 I Vogiatzis (149_CR133) 2011; 140 CW Chen (149_CR25) 2015; 10 H Müllerova (149_CR19) 2015; 147 DE Niewoehner (149_CR49) 1999; 340 Jadwiga A. Wedzicha (149_CR10) 2017; 49 P Schuetz (149_CR73) 2017; 10 M Carrera (149_CR102) 2009; 24 AJ White (149_CR2) 2003; 58 SH Jeong (149_CR22) 2016; 11 TH Kiser (149_CR59) 2014; 189 PK Plant (149_CR108) 2000; 355 M Confalonieri (149_CR125) 2005; 25 H Sheikh Motahar Vahedi (149_CR158) 2013; 58 I Torres-Sánchez (149_CR149) 2017; 62 JA Walters (149_CR55) 2018; 3 N Kramer (149_CR110) 1995; 151 D Chandra (149_CR104) 2012; 185 DJ Vollenweider (149_CR76) 2012; 12 P Rogliani (149_CR45) 2014; 108 J Pilcher (149_CR94) 2017; 22 M Guerrero (149_CR34) 2016; 11 PK Plant (149_CR111) 2001; 56 Bartolome R. Celli (149_CR12) 2017; 50 T Eaton (149_CR144) 2009; 14 |
| References_xml | – volume: 27 start-page: 324 issue: 3 year: 2012 ident: 149_CR88 publication-title: J Crit Care doi: 10.1016/j.jcrc.2011.07.075 – volume: 341 start-page: c5462 year: 2010 ident: 149_CR83 publication-title: BMJ doi: 10.1136/bmj.c5462 – volume: 24 start-page: 473 issue: 3 year: 2009 ident: 149_CR102 publication-title: J Crit Care doi: 10.1016/j.jcrc.2008.08.007 – volume: 341 start-page: 1555 issue: 8860 year: 1993 ident: 149_CR109 publication-title: Lancet doi: 10.1016/0140-6736(93)90696-E – volume: 13 start-page: 1297 year: 2018 ident: 149_CR36 publication-title: Int J Chron Obstruct Pulmon Dis. doi: 10.2147/COPD.S153631 – volume: 12 start-page: 2687 year: 2017 ident: 149_CR29 publication-title: Int J Chron Obstruct Pulmon Dis doi: 10.2147/COPD.S145253 – volume: 26 start-page: 630 year: 2013 ident: 149_CR46 publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2013.03.020 – volume: 12 start-page: 2046 issue: 6 year: 2018 ident: 149_CR95 publication-title: Clin Respir J doi: 10.1111/crj.12772 – volume: 151 start-page: 1799 issue: 6 year: 1995 ident: 149_CR110 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.151.6.7767523 – volume: 82 start-page: 148 issue: 2 year: 2011 ident: 149_CR116 publication-title: Respiration doi: 10.1159/000324259 – volume: 66 start-page: 107 issue: 2 year: 1972 ident: 149_CR80 publication-title: Br J Dis Chest doi: 10.1016/0007-0971(72)90016-2 – volume: 37 start-page: 1780 issue: 11 year: 2011 ident: 149_CR87 publication-title: Intensive Care Med doi: 10.1007/s00134-011-2354-6 – ident: 149_CR9 – volume: 3 start-page: CD006897 year: 2018 ident: 149_CR55 publication-title: Cochrane Database Syst Rev – volume: 157 start-page: 1498 year: 1998 ident: 149_CR69 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.157.5.9711044 – volume: 2 start-page: 735 issue: 5607 year: 1968 ident: 149_CR79 publication-title: Br Med J doi: 10.1136/bmj.2.5607.735 – volume: 326 start-page: 185 issue: 7382 year: 2003 ident: 149_CR106 publication-title: BMJ doi: 10.1136/bmj.326.7382.185 – volume: 106 start-page: 1429 issue: 10 year: 2012 ident: 149_CR155 publication-title: Respir Med doi: 10.1016/j.rmed.2012.05.005 – volume: 56 start-page: 708 issue: 9 year: 2001 ident: 149_CR111 publication-title: Thorax doi: 10.1136/thorax.56.9.708 – volume: 9 start-page: 23 issue: 1 year: 2014 ident: 149_CR134 publication-title: Intern Emerg Med doi: 10.1007/s11739-011-0727-z – volume: 98 start-page: 99 issue: 2 year: 2004 ident: 149_CR6 publication-title: Respir Med doi: 10.1016/j.rmed.2003.09.001 – volume: 13 start-page: e0191243 issue: 1 year: 2018 ident: 149_CR17 publication-title: PLoS One doi: 10.1371/journal.pone.0191243 – volume: 51 start-page: 143 issue: 2 year: 2010 ident: 149_CR82 publication-title: Clin Infect Dis doi: 10.1086/653527 – ident: 149_CR1 – volume: 157 start-page: 1736 issue: 15 year: 1997 ident: 149_CR40 publication-title: A meta-analysis Arch Intern Med doi: 10.1001/archinte.1997.00440360162018 – volume: 114 start-page: 1636 issue: 6 year: 1998 ident: 149_CR100 publication-title: Chest doi: 10.1378/chest.114.6.1636 – volume: 47 start-page: 34 issue: 1 year: 1992 ident: 149_CR98 publication-title: Thorax doi: 10.1136/thx.47.1.34 – volume: 181 start-page: 1016 issue: 10 year: 2010 ident: 149_CR153 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201001-0054ED – volume: 121 start-page: 39 year: 2016 ident: 149_CR63 publication-title: Respir Med doi: 10.1016/j.rmed.2016.10.013 – volume: 11 start-page: 685 year: 2014 ident: 149_CR31 publication-title: Ann Am Thorac Soc. doi: 10.1513/AnnalsATS.201310-358OC – volume: 48 start-page: 279 issue: 1 year: 2016 ident: 149_CR35 publication-title: Eur Respir J doi: 10.1183/13993003.00426-2016 – volume: 14 start-page: 98 year: 2014 ident: 149_CR148 publication-title: BMC Pulm Med doi: 10.1186/1471-2466-14-98 – volume: 63 start-page: 487 issue: 6 year: 2008 ident: 149_CR136 publication-title: Thorax doi: 10.1136/thx.2007.086371 – volume: 45 start-page: 691 issue: 3 year: 2015 ident: 149_CR115 publication-title: Eur Respir J doi: 10.1183/09031936.00053814 – volume: 25 start-page: 329 issue: 4 year: 2014 ident: 149_CR135 publication-title: Eur J Intern Med doi: 10.1016/j.ejim.2014.01.003 – volume: 43 start-page: 717 issue: 3 year: 2014 ident: 149_CR56 publication-title: Eur Respir J doi: 10.1183/09031936.00002913 – volume: 50 start-page: 1602426 issue: 2 year: 2017 ident: 149_CR105 publication-title: European Respiratory Journal doi: 10.1183/13993003.02426-2016 – volume: 358 start-page: 2020 issue: 9298 year: 2001 ident: 149_CR77 publication-title: Lancet doi: 10.1016/S0140-6736(01)07097-0 – volume: 349 start-page: g4315 year: 2014 ident: 149_CR156 publication-title: BMJ doi: 10.1136/bmj.g4315 – volume: 39 start-page: 1354 issue: 6 year: 2012 ident: 149_CR67 publication-title: Eur Respir J doi: 10.1183/09031936.00042111 – volume: 181 start-page: 150 issue: 2 year: 2010 ident: 149_CR81 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200906-0837OC – volume: 5 start-page: CD010172 year: 2017 ident: 149_CR91 publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD010172.pub2. – volume: 18 start-page: 503 issue: 6 year: 2001 ident: 149_CR75 publication-title: Int J Antimicrob Agents doi: 10.1016/S0924-8579(01)00435-6 – volume: 140 start-page: 744 issue: 3 year: 2011 ident: 149_CR133 publication-title: Chest doi: 10.1378/chest.10-3058 – volume: 161 start-page: 1191 issue: 4 Pt 1 year: 2000 ident: 149_CR119 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.161.4.9904065 – volume: 37 start-page: 1 year: 2016 ident: 149_CR64 publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2016.01.002 – volume: 326 start-page: 956 issue: 7396 year: 2003 ident: 149_CR112 publication-title: BMJ doi: 10.1136/bmj.326.7396.956 – volume: 22 start-page: 172 issue: 4 year: 2015 ident: 149_CR33 publication-title: Clin Pulm Med doi: 10.1097/CPM.0000000000000090 – volume: 165 start-page: 698 issue: 5 year: 2002 ident: 149_CR62 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.165.5.2109093 – volume: 20 start-page: 545 issue: 3 year: 2002 ident: 149_CR101 publication-title: Eur Respir J doi: 10.1183/09031936.02.00287402 – volume: 106 start-page: 196 year: 1987 ident: 149_CR8 publication-title: Ann Intern Med doi: 10.7326/0003-4819-106-2-196 – volume: 27 start-page: 179 issue: 2 year: 2014 ident: 149_CR57 publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2013.03.004 – volume: 309 start-page: 2223 issue: 21 year: 2013 ident: 149_CR52 publication-title: JAMA doi: 10.1001/jama.2013.5023 – volume: 11 start-page: 417 year: 2014 ident: 149_CR30 publication-title: Ann Am Thorac Soc doi: 10.1513/AnnalsATS.201308-254OC – volume: 49 start-page: 1600791 issue: 3 year: 2017 ident: 149_CR10 publication-title: European Respiratory Journal doi: 10.1183/13993003.00791-2016 – volume: 17 start-page: 143 issue: 1 year: 2017 ident: 149_CR92 publication-title: BMC Pulm Med. doi: 10.1186/s12890-017-0486-3 – volume: 14 start-page: 230 issue: 2 year: 2009 ident: 149_CR144 publication-title: Respirology doi: 10.1111/j.1440-1843.2008.01418.x – volume: 181 start-page: 1072 issue: 10 year: 2010 ident: 149_CR141 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200908-1203OC – volume: 79 start-page: 116 issue: 2 year: 2011 ident: 149_CR147 publication-title: Pneumonol Alergol Pol doi: 10.5603/ARM.27674 – volume: 340 start-page: 1941 issue: 25 year: 1999 ident: 149_CR49 publication-title: N Engl J Med doi: 10.1056/NEJM199906243402502 – volume: 131 start-page: 9 issue: 1 year: 2007 ident: 149_CR71 publication-title: Chest doi: 10.1378/chest.06-1500 – volume: 59 start-page: 1550 issue: 10 year: 2014 ident: 149_CR61 publication-title: Respir Care doi: 10.4187/respcare.03036 – volume: 15 start-page: R283 issue: 6 year: 2011 ident: 149_CR118 publication-title: Crit Care doi: 10.1186/cc10567 – volume: 348 start-page: 2618 issue: 26 year: 2003 ident: 149_CR50 publication-title: N Engl J Med doi: 10.1056/NEJMoa023161 – ident: 149_CR128 – volume: 58 start-page: 73 year: 2003 ident: 149_CR2 publication-title: Thorax doi: 10.1136/thorax.58.1.73 – volume: 8 start-page: 21 issue: 1 year: 2011 ident: 149_CR160 publication-title: COPD. doi: 10.3109/15412555.2010.540273 – volume: 11 start-page: e0158727 issue: 6 year: 2016 ident: 149_CR20 publication-title: PLoS One doi: 10.1371/journal.pone.0158727 – volume: 149 start-page: 1197 issue: 5 year: 2016 ident: 149_CR28 publication-title: Chest doi: 10.1378/chest.15-1504 – volume: 29 start-page: 318 issue: 5 year: 2009 ident: 149_CR151 publication-title: J Cardiopulm Rehabil Prev. doi: 10.1097/HCR.0b013e3181ac7bb8 – volume: 36 start-page: 1042 issue: 5 year: 2010 ident: 149_CR137 publication-title: Eur Respir J doi: 10.1183/09031936.00203809 – volume: 38 start-page: 1215 issue: 5 year: 2011 ident: 149_CR132 publication-title: Eur Respir J doi: 10.1183/09031936.00088611 – volume: 21 start-page: 806 year: 2015 ident: 149_CR145 publication-title: Med Sci Monit doi: 10.12659/MSM.895027 – volume: 108 start-page: 307 year: 2014 ident: 149_CR45 publication-title: Respir Med doi: 10.1016/j.rmed.2013.10.022 – volume: 14 start-page: 37 issue: 1 year: 2017 ident: 149_CR143 publication-title: COPD. doi: 10.1080/15412555.2016.1209476 – volume: 51 start-page: 1701312 year: 2018 ident: 149_CR157 publication-title: Eur Respir J doi: 10.1183/13993003.01312-2017 – volume: 62 start-page: 209 issue: 2 year: 2017 ident: 149_CR149 publication-title: Respir Care doi: 10.4187/respcare.04597 – volume: 29 start-page: 1224 issue: 6 year: 2007 ident: 149_CR13 publication-title: Eur Respir J doi: 10.1183/09031936.00109906 – volume: 355 start-page: 1931 issue: 9219 year: 2000 ident: 149_CR108 publication-title: Lancet doi: 10.1016/S0140-6736(00)02323-0 – volume: 75 start-page: 359 issue: 6 year: 2018 ident: 149_CR39 publication-title: Am J Health Syst Pharm doi: 10.2146/ajhp160979 – ident: 149_CR127 – volume: 132 start-page: 1741 issue: 6 year: 2007 ident: 149_CR53 publication-title: Chest doi: 10.1378/chest.07-0208 – volume: 11 start-page: 1857 year: 2016 ident: 149_CR22 publication-title: Int J Chron Obstruct Pulmon Dis. doi: 10.2147/COPD.S115581 – volume: 370 start-page: 786 year: 2007 ident: 149_CR66 publication-title: Lancet doi: 10.1016/S0140-6736(07)61382-8 – volume: 12 start-page: CD010257 year: 2012 ident: 149_CR76 publication-title: Cochrane Database Syst Rev – volume: 16 start-page: 197 year: 2003 ident: 149_CR43 publication-title: Pulm Pharmacol Ther doi: 10.1016/S1094-5539(03)00025-7 – volume: 50 start-page: 755 issue: 7 year: 1995 ident: 149_CR124 publication-title: Thorax doi: 10.1136/thx.50.7.755 – volume: 195 start-page: 843 issue: 7 year: 2017 ident: 149_CR122 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201610-2102ED – volume: 189 start-page: 1052 issue: 9 year: 2014 ident: 149_CR59 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201401-0058OC – volume: 48 start-page: 211 year: 2018 ident: 149_CR42 publication-title: Pulm Pharmacol Ther doi: 10.1016/j.pupt.2017.12.007 – volume: 59 start-page: 1825 issue: 12 year: 2014 ident: 149_CR117 publication-title: Respir Care doi: 10.4187/respcare.03009 – volume: 303 start-page: 2359 issue: 23 year: 2010 ident: 149_CR58 publication-title: JAMA doi: 10.1001/jama.2010.796 – volume: 66 start-page: 585 year: 2011 ident: 149_CR15 publication-title: Thorax doi: 10.1136/thx.2010.152876 – volume: 119 start-page: 726 issue: 3 year: 2001 ident: 149_CR60 publication-title: Chest doi: 10.1378/chest.119.3.726 – volume: 117 start-page: 237 year: 2016 ident: 149_CR24 publication-title: Respir Med doi: 10.1016/j.rmed.2016.05.003 – volume: 354 start-page: 456 issue: 9177 year: 1999 ident: 149_CR48 publication-title: Lancet doi: 10.1016/S0140-6736(98)11326-0 – volume: 11 start-page: 1983 year: 2016 ident: 149_CR85 publication-title: Int J Chron Obstruct Pulmon Dis. doi: 10.2147/COPD.S112820 – volume: 25 start-page: 348 issue: 2 year: 2005 ident: 149_CR125 publication-title: Eur Respir J doi: 10.1183/09031936.05.00085304 – volume: 12 start-page: 306 issue: 3 year: 2015 ident: 149_CR32 publication-title: COPD. doi: 10.3109/15412555.2014.933954 – volume: 11 start-page: e0150737 issue: 3 year: 2016 ident: 149_CR34 publication-title: PLoS One doi: 10.1371/journal.pone.0150737 – volume: 185 start-page: 152 issue: 2 year: 2012 ident: 149_CR104 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201106-1094OC – volume: 7 start-page: 59 issue: 1 year: 2017 ident: 149_CR121 publication-title: Ann Intensive Care doi: 10.1186/s13613-017-0273-6 – volume: 10 start-page: CD007498 year: 2017 ident: 149_CR73 publication-title: Cochrane Database Syst Rev – volume: 50 start-page: 1701432 issue: 3 year: 2017 ident: 149_CR12 publication-title: European Respiratory Journal doi: 10.1183/13993003.01432-2017 – volume: 37 start-page: 508 issue: 3 year: 2011 ident: 149_CR23 publication-title: Eur Respir J doi: 10.1183/09031936.00043710 – volume: 188 start-page: e13 issue: 8 year: 2013 ident: 149_CR129 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201309-1634ST – volume: 363 start-page: 1128 issue: 12 year: 2010 ident: 149_CR18 publication-title: N Engl J Med doi: 10.1056/NEJMoa0909883 – volume: 22 start-page: 1149 issue: 6 year: 2017 ident: 149_CR94 publication-title: Respirology doi: 10.1111/resp.13050 – volume: 55 start-page: 550 issue: 7 year: 2000 ident: 149_CR84 publication-title: Thorax doi: 10.1136/thorax.55.7.550 – volume: 48 start-page: 1121 issue: 7 year: 2016 ident: 149_CR27 publication-title: Int Urol Nephrol doi: 10.1007/s11255-016-1272-5 – volume: 18 start-page: 148 issue: 3 year: 2013 ident: 149_CR154 publication-title: Physiother Res Int doi: 10.1002/pri.1541 – volume: 147 start-page: 999 issue: 4 year: 2015 ident: 149_CR19 publication-title: Chest doi: 10.1378/chest.14-0655 – volume: 8 start-page: CD011826 year: 2016 ident: 149_CR41 publication-title: Cochrane Database Syst Rev – volume: 5 start-page: 297 issue: 14 year: 2017 ident: 149_CR86 publication-title: Ann Transl Med doi: 10.21037/atm.2017.06.52 – volume: 302 start-page: 1059 issue: 10 year: 2009 ident: 149_CR72 publication-title: JAMA doi: 10.1001/jama.2009.1297 – volume: 10 start-page: 1147 year: 2015 ident: 149_CR25 publication-title: Int J Chron Obstruct Pulmon Dis. doi: 10.2147/COPD.S85831 – volume: 58 start-page: 589 issue: 4 year: 2013 ident: 149_CR89 publication-title: Respir Care doi: 10.4187/respcare.02086 – volume: 195 start-page: 871 issue: 7 year: 2017 ident: 149_CR120 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201601-0083OC – volume: 10 start-page: 823 year: 2015 ident: 149_CR16 publication-title: Int J Chron Obstruct Pulmon Dis. – volume: 38 start-page: 145 issue: 1 year: 2010 ident: 149_CR123 publication-title: Crit Care Med doi: 10.1097/CCM.0b013e3181b78abe – volume: 103 start-page: 1526 issue: 10 year: 2009 ident: 149_CR140 publication-title: Respir Med doi: 10.1016/j.rmed.2009.04.011 – volume: 22 start-page: 109 issue: 1 year: 2018 ident: 149_CR126 publication-title: Crit Care doi: 10.1186/s13054-018-2033-x – volume: 374 start-page: 250 issue: 9685 year: 2009 ident: 149_CR113 publication-title: Lancet doi: 10.1016/S0140-6736(09)60496-7 – volume: 13 start-page: 439 issue: 4 year: 2016 ident: 149_CR44 publication-title: COPD. doi: 10.3109/15412555.2015.1101435 – volume: 9 start-page: 377 issue: 8 year: 1992 ident: 149_CR78 publication-title: An Med Interna – volume: 54 start-page: 71 issue: 1 year: 2009 ident: 149_CR114 publication-title: Respir Care – volume: 174 start-page: 867 year: 2006 ident: 149_CR3 publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200604-506OC – volume: 77 start-page: 121 issue: 2 year: 2009 ident: 149_CR130 publication-title: Respiration doi: 10.1159/000192773 – volume: 8 start-page: 273 year: 2013 ident: 149_CR38 publication-title: Int J Chron Obstruct Pulmon Dis. – volume: 131 start-page: 58 year: 2017 ident: 149_CR90 publication-title: Respir Med doi: 10.1016/j.rmed.2017.08.005 – volume: 13 start-page: 187 issue: 2 year: 2013 ident: 149_CR14 publication-title: Expert Rev Pharmacoecon Outcomes Res doi: 10.1586/erp.13.9 – volume: 5 start-page: 202 issue: 3 year: 2010 ident: 149_CR131 publication-title: Multidiscip Respir Med doi: 10.1186/2049-6958-5-3-202 – volume: 67 start-page: 957 issue: 11 year: 2012 ident: 149_CR5 publication-title: Thorax doi: 10.1136/thoraxjnl-2011-201518 – volume: 6 start-page: 50 issue: 2 year: 2018 ident: 149_CR7 publication-title: Medical Sciences doi: 10.3390/medsci6020050 – volume: 11 start-page: 1077 year: 2016 ident: 149_CR93 publication-title: Int J Chron Obstruct Pulmon Dis. doi: 10.2147/COPD.S104616 – volume: 59 start-page: 387 issue: 5 year: 2004 ident: 149_CR152 publication-title: Thorax doi: 10.1136/thx.2003.008730 – volume: 71 start-page: 988 issue: 11 year: 2016 ident: 149_CR138 publication-title: Thorax doi: 10.1136/thoraxjnl-2016-208460 – volume: 36 start-page: 301 issue: 2 year: 2010 ident: 149_CR139 publication-title: Eur Respir J doi: 10.1183/09031936.00112909 – volume: 359 start-page: 2355 year: 2008 ident: 149_CR65 publication-title: N Engl J Med doi: 10.1056/NEJMra0800353 – volume: 95 start-page: 1638 issue: 9 year: 2014 ident: 149_CR142 publication-title: Arch Phys Med Rehabil doi: 10.1016/j.apmr.2014.05.007 – volume: 19 start-page: 119 issue: 1 year: 2018 ident: 149_CR70 publication-title: Respir Res doi: 10.1186/s12931-018-0820-1 – ident: 149_CR96 doi: 10.1111/crj.12942 – volume: 42 start-page: 384 issue: 8 year: 2006 ident: 149_CR159 publication-title: Arch Bronconeumol doi: 10.1157/13091646 – volume: 374 start-page: 2222 issue: 23 year: 2016 ident: 149_CR47 publication-title: N Engl J Med doi: 10.1056/NEJMoa1516385 – volume: 7 start-page: CD004104 year: 2017 ident: 149_CR107 publication-title: Cochrane Database Syst Rev – volume: 13 start-page: 82 issue: 1 year: 2016 ident: 149_CR37 publication-title: COPD doi: 10.3109/15412555.2015.1057276 – volume: 161 start-page: 807 issue: 3 Pt 1 year: 2000 ident: 149_CR103 publication-title: Am J Respir Crit Care Med doi: 10.1164/ajrccm.161.3.9808143 – volume: 32 start-page: 163 issue: 3 year: 2012 ident: 149_CR146 publication-title: J Cardiopulm Rehabil Prev doi: 10.1097/HCR.0b013e318252f0b2 – volume: 66 start-page: 43 issue: 1 year: 2011 ident: 149_CR97 publication-title: Thorax doi: 10.1136/thx.2010.153114 – volume: 50 start-page: 1700075 issue: 3 year: 2017 ident: 149_CR11 publication-title: European Respiratory Journal doi: 10.1183/13993003.00075-2017 – volume: 15 start-page: 687 issue: 5 year: 2011 ident: 149_CR54 publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.10.0540 – volume: 58 start-page: 1873 issue: 11 year: 2013 ident: 149_CR158 publication-title: Respir Care doi: 10.4187/respcare.02160 – volume: 171 start-page: 1939 issue: 21 year: 2011 ident: 149_CR51 publication-title: Arch Intern Med doi: 10.1001/archinternmed.2011.530 – volume: 48 start-page: 40 year: 2016 ident: 149_CR74 publication-title: Int J Infect Dis doi: 10.1016/j.ijid.2016.04.024 – volume: 333 start-page: 817 issue: 13 year: 1995 ident: 149_CR99 publication-title: N Engl J Med doi: 10.1056/NEJM199509283331301 – volume: 144 start-page: 1134 issue: 4 year: 2013 ident: 149_CR68 publication-title: Chest doi: 10.1378/chest.13-0488 – volume: 10 start-page: 81 issue: 2 year: 2013 ident: 149_CR21 publication-title: Ann Am Thorac Soc. doi: 10.1513/AnnalsATS.201208-043OC – volume: 58 start-page: 752 issue: 9 year: 2003 ident: 149_CR150 publication-title: Thorax doi: 10.1136/thorax.58.9.752 – volume: 58 start-page: 589 issue: 7 year: 2003 ident: 149_CR4 publication-title: Thorax doi: 10.1136/thorax.58.7.589 – volume: 14 start-page: 165 issue: 3 year: 2015 ident: 149_CR26 publication-title: Tanaffos |
| SSID | ssj0000651354 |
| Score | 2.3861718 |
| SecondaryResourceType | review_article |
| Snippet | Background
Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional... Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional therapy; this... Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional... Main body Several treatments exist for severe AECOPD patients requiring hospitalization. Some treatments such as steroids and NIMV (in patients admitted with a... Background: Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in additional... Abstract Background Patients with chronic obstructive pulmonary disease (COPD) may experience an acute worsening of respiratory symptoms that results in... |
| SourceID | doaj pubmedcentral csuc proquest gale pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 36 |
| SubjectTerms | Acute exacerbation Adult respiratory distress syndrome Antibiotics Antibiòtics Artificial respiration Bronchodilators Care and treatment Chronic obstructive lung disease Chronic obstructive pulmonary disease Chronic obstructive pulmonary diseases COPD Critical Care Medicine Drugs Dyspnea Health aspects Hospital patients Hospitalization Hospitals Intensive Intensive care Malalties pulmonars obstructives cròniques Medicine Medicine & Public Health Mortality Oxigen Oxygen Oxygen therapy Patients Pneumology/Respiratory System Rehabilitation Respiració artificial Respiratory system agents Respiratory therapy Review Steroids Thoracic Surgery Ventilators |
| SummonAdditionalLinks | – databaseName: ProQuest Central dbid: BENPR link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELegQ4iX8TkIDAgSEhIoWmI7jsML2sYmHlipEEh9s1znDJNQ2qUt4s_nLnFTMsReeMhD43NS5853P3_9jrGXDjINGAkSQCyaSLAy0egSEimdknY281q0B4U_FuOxnk7LSZhwW4ZtlRuf2Drqau5ojvwAXSznGfHDvVtcJJQ1ilZXQwqN62yHmMrkiO0cnYwnn_tZFgywmWhToSGO1okq82lY2sy0OlhKYvTC0TRdskzSQXAaueXaBSr_vx32HxHr8m7KS0uqbaQ6vf2_bbzDdgNGjQ87o7rLrkF9j908C6vw99nZds9MPPcxxlZoILZuvYIYflmHmurmAan0-NPk_dvY1vF6QZMLVVzbpmMbj7tjMw_Y19OTL8cfkpCWIXGqUKvEi4rzsipcZosUKuVUWjkrJbfCcY9ey2fKgU4J2eSU3NpDmlkLGWiXp74Ue2xUz2t4xOKyknomtQXwQMhRK1mC58KWIEXhVcTSjT6MC5zllDrjh2nHLlqZToUGVWhIhSaN2Ou-yqIj7LhaGJVsMLhA4-zKENl2_4MunhbciJxo8yN2RKbQP5Vk2xvz5psJ_dxol2Yz5XyliJWnmmlw0opKCJ-LHKF4xJ6TIZnulGvvXsxhjgM_RIMCX_OqlSAHg211NpyTwC9GVF0Dyf2BJDoGNyzeWJkJjmlptiYWsRd9MdWkzXY1zNckkyFuFIh8I_aws-2-0Yh4CPVh7WJg9YOvMiypz7-3tOUqI7JCHbE3m_6x_Vv_1NDjqxvxhN3i1H1pRwffZ6NVs4an7Ib7uTpfNs-CN_gNZv1i8Q priority: 102 providerName: ProQuest – databaseName: SpringerLINK Contemporary 1997-Present dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Zb9QwELbQghAv3EegQJCQkEBRE9txHN5KoeKBlopLfbO8kzFUQtkq2SB-PjNJNiXlkOAhD7seb9b2HJ-P-SzEY8DMIkWCBAmLJhq9Tiy5hERrMNovl8GqPlH4TXFwYI-OysMxj7vdnHbfbEn2nro3a2u2W830WzT15UeXCc3Tz1O0s2yN795_mhZWKKZmKtfjDuZva85i0ALaDkbG_l_98k-B6eyhyTM7p31A2rvyX025Ki6P-DPeGRTmmjiH9XVxcX_cYb8h9k_Pw8SrEFPcxAZjD90aY_zugUZhWOPj0t23hy-fx76OuxNeOKji2jcDk3g8pMTcFB_3Xn3YfZ2MVy4kYAqzToKqpCyrAjJfpFgZMGkFXmvpFchAHilkBtCmjFpyvrg6YJp5jxlayNNQqltiUa9qvCPistJ2qa1HDMio0BpdYpDKl6hVEUwk0s0gOBj5yPlajK-un5dY44ZuctRNjrvJpZF4OlU5Gcg4_i5MI-socGADfu2YSHv6wI9MC-lUzpT4kXjB4z_9Ksv2X6yaz260YWchzZYGQmWYcadaWgTtVaVUyFVOMDsSD1l73JDBOrkOt5PTpI6QnqLXPOkl2HlQW8GPORDUY0zDNZPcmkmS0cO8eKOhbnQ6rSMUImXGFIqReDQVc00-SFfjqmOZjDChIlQbiduDQk-NJjTDiI5qFzNVn_XKvKQ-_tJTkpuMiQhtJJ5tFP70b_1xhO7-k_Q9cUmyxfDhDbklFuumw_viAnxbH7fNg94H_AAXQVUj priority: 102 providerName: Springer Nature |
| Title | Management of severe acute exacerbations of COPD: an updated narrative review |
| URI | https://link.springer.com/article/10.1186/s40248-018-0149-0 https://www.ncbi.nlm.nih.gov/pubmed/30302247 https://www.proquest.com/docview/2122214867 https://www.proquest.com/docview/2117823251 https://recercat.cat/handle/2072/356150 https://pubmed.ncbi.nlm.nih.gov/PMC6167788 https://doaj.org/article/8c01b6cfd60146db8ec4a3d33f535916 |
| Volume | 13 |
| WOSCitedRecordID | wos000446483100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVADU databaseName: BioMed Central Open Access Free customDbUrl: eissn: 2049-6958 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0000651354 issn: 2049-6958 databaseCode: RBZ dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.biomedcentral.com/search/ providerName: BioMedCentral – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2049-6958 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0000651354 issn: 2049-6958 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2049-6958 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0000651354 issn: 2049-6958 databaseCode: 7X7 dateStart: 20101201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2049-6958 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0000651354 issn: 2049-6958 databaseCode: BENPR dateStart: 20101201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database (ProQuest) customDbUrl: eissn: 2049-6958 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0000651354 issn: 2049-6958 databaseCode: PIMPY dateStart: 20101201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 2049-6958 dateEnd: 20191231 omitProxy: false ssIdentifier: ssj0000651354 issn: 2049-6958 databaseCode: RSV dateStart: 20101201 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3db9MwELegILQXxOcIjBIkJCRQtMR2HIe3bWwCiZZqfKg8Wa5zFpOmdOoH4s_nLk6zZgh44SGVUp_T-u5893Ns_8zYCweZBswECSAWTSRYmWgMCYmUTkk7m3ktmo3CH4rxWE-n5WTrqC9aExbogYPi9rVLs5lyvlJEc1LNNDhpRSWEz0WO2IaiL6KercFUiMF5JnLZTmNmWu0vJbF34ciZLlkmaS8RDdxy7Vra_t-D81Z2urpy8sr0aZOVTu6w2y2cjA9CM-6ya1DfY7dG7YT5fTa6XN4Sz32MaRAWEFu3XkEMP61DpYZXdlR69HHy9k1s63h9Qe8Bqri2i0AMHocdLg_Yl5Pjz0fvkvYEhcSpQq0SLyrOy6pwmS1SqJRTaeWslNwKxz0GGJ8pBzolEJLTOdQe0sxayEC7PPWleMgG9byGRywuK6lnUlsADwTytJIleC5sCVIUXkUs3ajTuJZenE65ODfNMEMrEyxg0AKGLGDSiL3qqlwEbo2_C6ONDOYBWDi7MsSL3d3QxdOCG5ETw33EDsmS3VNJtvkCPcu0nmX-5VkRe0Z-YMKG1C4SmIMcx2gI3AT-zMtGgmIBttXZdksDaoxYtXqSez1J7MOuX7zxNdPGkKVBUMF5RoyIEXveFVNNWhdXw3xNMhlCPIEgNWK7wTW7RiM4IYCGtYue0_a00i-pz743DOMqI15BHbHXG_e-_Ft_tNDj_6H0J2yHUx-lJRp8jw1WizU8ZTfdj9XZcjFk14tp0XzqIbtxeDyenA6bjo93k_ejyTe8O_309RevxFfY |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3db9MwELemDgEvfH8EBgsSCAkULbEdx0FCaGxMq9aWPgypezKuc4FJKC394OOf4m_kLklTMsTe9sBDHlqfm9q--92dfb5j7KmDSANqggDQFg0kWBlohIRASqekHY9zLcqLwr1kMNCjUTrcYL9Wd2EorHKFiSVQZxNHe-Q7CLGcR5Qf7s30a0BVo-h0dVVCo2KLI_j5HV22-evuPq7vM84P3h3vHQZ1VYHAqUQtglxknKdZ4iKbhJApp8LMWSm5FY7nKHR5pBzokBRzTLWZcwgjayEC7eIwp-RLCPmb2CHWHbY57PaHJ82uDir0SJSl19Bu14FK41F9lBpptTOXlEEMvXd6ZBqELWXYcfOlq0sH_K0g_tCQZ6M3zxzhlprx4Pr_Nqc32LXaBvd3K6G5yTaguMUu9-sog9usv44J8ie5j7YDzMC3brkAH35Yh5xY7XNS69774f4r3xb-ckqbJ5lf2FmVTd2vrgXdYR8uZDB3WaeYFHCf-Wkm9VhqC5ADWcZayRRyLmwKUiS58li4Wn_j6pzsVBrkiyl9M61MxTIGWcYQy5jQYy-aLtMqIcn5xMhUBpUnzJxdGEom3nygh4cJNyKmsgAee0us1_wq0ZZfTGafTI1jRrswGiuXZ4qyDmVjDU5akQmRxyJGV8Nj28S4prrF28Cn2Y3RsUVrV-BrnpcUBKA4VmfreyA4Y5SKrEW51aJE4HPt5hVXmxp452bN0h570jRTTwomLGCyJJoI7WKBlr3H7lWy1AwaLTqyarF30pKy1qy0W4rTz2VadhVRMkbtsZcreVz_rX-u0IPzB7HNrhwe93um1x0cPWRXOUEHRa_wLdZZzJbwiF1y3xan89njGol89vGiBfU3acLAPg |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdQQRMv43sLDBYkJCRQtMR2HIe3sVGB2EolPrQ3y3HOMAmlVZoi_nzukjQj40NCPOSh9bmpz-e7n79-x9gTB4kGjAQRIBaNJFgZaXQJkZROSVsUXov2ovBJNpvps7N83uc5XW1Ou2-2JLs7DcTSVDUHy9J3Q1yrg5UkKi6cBtMj8wjn7Fcl5Qyi6fr7T8MiC8bXRKSy3838bc1RPJq41dr17P2_-uifgtTlA5SXdlHb4DS98d_Nusm2e1waHnaGdItdgeo22zrtd97vsNOLczLhwocYT6GG0Lp1AyF8tw57p1v7o9Kjd_PjF6GtwvWSFhTKsLJ1xzAedldl7rKP01cfjl5HfSqGyKlMNZEXJed5mbnEZjGUyqm4dFZKboXjHj2VT5QDHROaSSmhtYc4sRYS0C6NfS7usUm1qGCXhXkpdSG1BfBAaFErmYPnwuYgReZVwOJNhxjX85RTuoyvpp2vaGU6NRlUkyE1mThgz4Yqy46k4-_C2MsGAwrUzjaGCLaHD_TwOONGpESVH7CXZAvDr5Js-8Wi_mz6sW20i5NCOV8qYuIpCw1OWlEK4VORIvwO2D5Zkulutg4uxRymONlDBCjwNU9bCXIq2FZn-7sRqDGi5xpJ7o0k0Rm4cfHGWk3vjFYG0QnnCVErBuzxUEw16YBdBYs1ySSIFQWi3YDtdMY9NBpRDiE9rJ2NzH6klXFJdf6lpSpXCREU6oA93xj_xd_6Yw_d_yfpfbY1P56akzeztw_YdU6Dh8538D02aeo1PGTX3LfmfFU_al3DD_ugYOs |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Management+of+severe+acute+exacerbations+of+COPD%3A+an+updated+narrative+review&rft.jtitle=Multidisciplinary+respiratory+medicine&rft.au=Crisafulli%2C+Ernesto&rft.au=Barbeta%2C+Enric&rft.au=Ielpo%2C+Antonella&rft.au=Torres%2C+Antoni&rft.date=2018-10-02&rft.pub=BioMed+Central+Ltd&rft.issn=1828-695X&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1186%2Fs40248-018-0149-0&rft.externalDocID=A557665830 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2049-6958&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2049-6958&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2049-6958&client=summon |