Protocol, rationale and design of BE-PEOPLE (Bedaquiline enhanced exposure prophylaxis for LEprosy in the Comoros): a cluster randomized trial on effectiveness of rifampicin and bedaquiline as post-exposure prophylaxis of leprosy contacts

Background Leprosy is an ancient infectious disease with an annual global incidence of around 200,000 over the past decade. Since 2018, the World Health Organization (WHO) recommends single-dose rifampicin as post-exposure prophylaxis (SDR-PEP) for contacts of leprosy patients. The Post ExpOsure Pro...

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Bibliographic Details
Published in:	BMC infectious diseases Vol. 23; no. 1; pp. 310 - 9
Main Authors:	Younoussa, Assoumani, Samidine, Said Nourdine, Bergeman, Auke T., Piubello, Alberto, Attoumani, Nissad, Grillone, Silahi Halifa, Braet, Sofie Marijke, Tsoumanis, Achilleas, Baco, Abdallah, Mzembaba, Aboubacar, Salim, Zahara, Amidy, Mohamed, Grillone, Saverio, Snijders, Rian, Corstjens, Paul, Ortuno-Gutierrez, Nimer, Hoof, Carolien, Geluk, Annemieke, de Jong, Bouke C., Hasker, Epco
Format:	Journal Article
Language:	English
Published:	London BioMed Central 09.05.2023 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	(AM)resistance Antibodies Bedaquiline Clusters Comoros Disease prevention Drug dosages Drug therapy Effectiveness Exposure Humans Immunoglobulin M Infectious Diseases Internal Medicine Leprosy Leprosy - drug therapy Leprosy - epidemiology Leprosy - prevention & control Medical Microbiology Medicine Medicine & Public Health Mycobacterium leprae Parasitology Patient outcomes Post exposure Prophylaxis Prophylaxis Randomized Controlled Trials as Topic Reduction Rifampin Rifampin - therapeutic use Serology Single dose rifampicin Study Protocol Surveillance Towns Tropical Medicine Tuberculosis Villages Comoros Belgium Madagascar Comoro Islands Leprosy Surveillance Post exposure Prophylaxis (AM)resistance Single dose rifampicin Bedaquiline
ISSN:	1471-2334, 1471-2334
Online Access:	Get full text
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