A genetically encoded photoactivatable Rac controls the motility of living cells

A light touch on proteins Many aspects of cellular function depend on when and where in the cell various protein activities are turned 'on' or 'off' at the molecular level. A new technique that uses light to manipulate the activity of a protein at precise times and places within...

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Vydáno v:	Nature (London) Ročník 461; číslo 7260; s. 104 - 108
Hlavní autoři:	Wu, Yi I., Frey, Daniel, Lungu, Oana I., Jaehrig, Angelika, Schlichting, Ilme, Kuhlman, Brian, Hahn, Klaus M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 03.09.2009 Nature Publishing Group
Témata:	Animals Avena - genetics Binding sites Biological and medical sciences Cell Line Cell Movement - radiation effects Cell physiology Cell Surface Extensions Cell Survival Cells Cryptochromes Crystal structure Crystallization Crystallography, X-Ray Embryo, Mammalian - cytology Enzyme Activation - radiation effects Fibroblasts Flavoproteins - chemistry Flavoproteins - genetics Flavoproteins - metabolism Fluorescence Recovery After Photobleaching Fundamental and applied biological sciences. Psychology Genetic Engineering - methods HeLa Cells Humanities and Social Sciences Humans Hydrogen bonds letter Measurement Mice Models, Molecular Molecular and cellular biology Motility Motility and taxis Motion pictures multidisciplinary Mutation Myosins - metabolism Physiological aspects Protein Conformation Proteins rac1 GTP-Binding Protein - chemistry rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism rac1 GTP-Binding Protein - radiation effects rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism rhoA GTP-Binding Protein Science Studies United States Germany Motility Enzyme Triphosphoric monoester hydrolases Photoactivation Rodentia dGTPase Esterases Recombinant cell Metazoa Cellular motility Vertebrata Regulation(control) Mammalia Mouse Embryonic cell Dynamics Hydrolases Cytoskeleton Mutation Fibroblast
ISSN:	0028-0836, 1476-4687, 1476-4687
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