Anthracyclines/trastuzumab: new aspects of cardiotoxicity and molecular mechanisms

•Anthracyclines and trastuzumab are effective chemotherapies that can cause cardiotoxicity.•Cardiotoxicity is due to a combination of ‘on-target’ and ‘off-target’ effects.•Neuregulin-1 in the microvascular endothelium is involved in cardiotoxicity.•ErbB2 could be a potential target for anticancer th...

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Bibliographic Details
Published in:	Trends in pharmacological sciences (Regular ed.) Vol. 36; no. 6; pp. 326 - 348
Main Authors:	Rochette, Luc, Guenancia, Charles, Gudjoncik, Aurélie, Hachet, Olivier, Zeller, Marianne, Cottin, Yves, Vergely, Catherine
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.06.2015 Elsevier
Subjects:	Advanced Basic Science Animals anthracyclines Anthracyclines - adverse effects Anthracyclines - pharmacology Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacology Cancer Cardiology and cardiovascular system Cardiotoxicity Drug Synergism Human health and pathology Humans Life Sciences Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidative Stress Pharmaceutical sciences Pharmacology trastuzumab Trastuzumab - adverse effects Trastuzumab - pharmacology trastuzumab cardiotoxicity anthracyclines oxidative stress
ISSN:	0165-6147, 1873-3735, 1873-3735
Online Access:	Get full text
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