Galectin-3 Deficiency Accelerates High-Fat Diet–Induced Obesity and Amplifies Inflammation in Adipose Tissue and Pancreatic Islets

Obesity-induced diabetes is associated with low-grade inflammation in adipose tissue and macrophage infiltration of islets. We show that ablation of galectin-3 (Gal-3), a galactoside-binding lectin, accelerates high-fat diet–induced obesity and diabetes. Obese LGALS3−/− mice have increased body weig...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 62; no. 6; pp. 1932 - 1944
Main Authors:	Pejnovic, Nada N., Pantic, Jelena M., Jovanovic, Ivan P., Radosavljevic, Gordana D., Milovanovic, Marija Z., Nikolic, Ivana G., Zdravkovic, Nemanja S., Djukic, Aleksandar L., Arsenijevic, Nebojsa N., Lukic, Miodrag L.
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01.06.2013
Subjects:	Ablation Adipose Tissue - immunology Adipose Tissue - metabolism Age Analysis Animals Antibodies Biological and medical sciences Blotting, Western Body fat Body Weight - genetics Body Weight - physiology Cells, Cultured Cytokines Diabetes Diabetes. Impaired glucose tolerance Diet Diet, High-Fat - adverse effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Flow Cytometry Galectin 3 - deficiency Galectin 3 - genetics Glucose Homeostasis Immunohistochemistry Inflammation Inflammation - genetics Inflammation - metabolism Insulin resistance Islets of Langerhans - immunology Islets of Langerhans - metabolism Lectins Medical sciences Metabolic diseases Metabolism Mice Mice, Inbred C57BL Mice, Mutant Strains Obesity Obesity - etiology Obesity - immunology Obesity - metabolism Original Research RNA, Small Interfering Endocrinopathy Obesity Adipose tissue Diet Diabetes mellitus Deficiency Nutrition disorder Inflammation Pancreas Nutritional status Feeding
ISSN:	0012-1797, 1939-327X, 1939-327X
Online Access:	Get full text
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