Dissociation of local and global skeletal muscle oxygen transport metrics in type 2 diabetes

Exercise capacity is impaired in type 2 diabetes, and this impairment predicts excess morbidity and mortality. This defect appears to involve excess skeletal muscle deoxygenation, but the underlying mechanisms remain unclear. We hypothesized that reduced blood flow, reduced local recruitment of bloo...

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Bibliographic Details
Published in:	Journal of diabetes and its complications Vol. 31; no. 8; pp. 1311 - 1317
Main Authors:	Mason McClatchey, P., Bauer, Timothy A., Regensteiner, Judith G., Schauer, Irene E., Huebschmann, Amy G., Reusch, Jane E.B.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.08.2017 Elsevier Limited
Subjects:	Adult Aerobics Aging Bicycling Blood Blood Vessels - physiopathology Capillary Resistance Diabetes Diabetes Mellitus, Type 2 - complications Diabetic Angiopathies - blood Diabetic Angiopathies - metabolism Diabetic Angiopathies - physiopathology Diabetic retinopathy Endocrinology & Metabolism Exercise Exercise capacity Exercise Tolerance Female Hemoglobins - analysis Humans Leg Male Metabolic syndrome Microcirculation Microvessels - physiopathology Middle Aged Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Musculoskeletal system Near-infrared spectroscopy Oxygen Oxygen - blood Oxygen - metabolism Oxygen Consumption Oxygen delivery Oxygen transport Oxyhemoglobins - metabolism Perfusion heterogeneity Physical fitness Regional Blood Flow Spectroscopy, Near-Infrared Spectrum analysis Type 2 diabetes Vascular Resistance Type 2 diabetes Perfusion heterogeneity Oxygen delivery Exercise capacity Oxygen transport Near-infrared spectroscopy exercise capacity oxygen transport oxygen delivery near-infrared spectroscopy type 2 diabetes perfusion heterogeneity
ISSN:	1056-8727, 1873-460X, 1873-460X
Online Access:	Get full text
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