Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

The protein hormone adiponectin is known to have many beneficial systemic effects, including promoting cell survival, anti-inflammation and insulin sensitivity. Phil Scherer and his colleagues have found that these pleiotropic effects are mediated by a ceramidase activity associated with the two kno...

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Bibliographic Details
Published in:	Nature medicine Vol. 17; no. 1; pp. 55 - 63
Main Authors:	Holland, William L, Miller, Russell A, Wang, Zhao V, Sun, Kai, Barth, Brian M, Bui, Hai H, Davis, Kathryn E, Bikman, Benjamin T, Halberg, Nils, Rutkowski, Joseph M, Wade, Mark R, Tenorio, Vincent M, Kuo, Ming-Shang, Brozinick, Joseph T, Zhang, Bei B, Birnbaum, Morris J, Summers, Scott A, Scherer, Philipp E
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.01.2011 Nature Publishing Group
Subjects:	631/443/319/2723 631/45/776/1178 631/80/82/23 Adenylate Kinase - metabolism Adiponectin - deficiency Adiponectin - genetics Adiponectin - physiology Adiponectin - therapeutic use Animals Apoptosis - physiology Biomedical and Life Sciences Biomedicine Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Cancer Research Cellular biology Ceramidases - drug effects Ceramidases - metabolism Ceramides - metabolism Enzyme Activation Gene Expression Regulation Health aspects Humans Infectious Diseases Insulin Insulin - physiology Kinetics Leptin - deficiency Lipids Metabolic Diseases Metabolism Metabolites Mice Mice, Obese Molecular Medicine Mortality Myocardial Infarction - drug therapy Myocytes, Cardiac - physiology Neurosciences Pancreatic beta cells Physiological aspects Properties Protein hormones Receptors, Adiponectin - physiology Signal transduction Upstream United States
ISSN:	1078-8956, 1546-170X, 1546-170X
Online Access:	Get full text
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