Effects of a dietary intervention with lacto-ovo-vegetarian and Mediterranean diets on apolipoproteins and inflammatory cytokines: results from the CARDIVEG study

Background Apolipoproteins have been recently proposed as novel markers of cardiovascular disease (CVD) risk. However, evidence regarding effects of diet on apolipoproteins is limited. Aim To compare the effects of Mediterranean diet (MD) and lacto-ovo vegetarian diet (VD) on apolipoproteins and tra...

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Vydáno v:Nutrition & metabolism Ročník 21; číslo 1; s. 9
Hlavní autoři: Pagliai, Giuditta, Tristan Asensi, Marta, Dinu, Monica, Cesari, Francesca, Bertelli, Alessia, Gori, Anna Maria, Giusti, Betti, Marcucci, Rossella, Sofi, Francesco, Colombini, Barbara
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 01.02.2024
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Analysis
Apolipoproteins
Atherosclerosis
blood
Body mass index
Carbohydrates
Cardiovascular disease
Cardiovascular diseases
Cardiovascular risk; apolipoproteins; Mediterranean diet; vegetarian diet
Cholesterol
Clinical Nutrition
Cytokines
Dairy products
Data collection
Diet
Diet therapy
Exercise
Health aspects
High density lipoprotein
Inflammation
Instrument industry
interleukin-17
Intervention
Laboratories
Legumes
Lipids
Lipoproteins
Meat
Meat products
Medicine
Medicine & Public Health
Mediterranean diet
Metabolic Diseases
Metabolism
Nutrition research
nutritional intervention
ovo-lacto vegetarian diet
Physiological aspects
Poultry
Prevention
Questionnaires
risk
Risk factors
Sexually transmitted diseases
Statistical analysis
STD
Triglycerides
Vegetarian diet
Vegetarianism
Weight control
United States
Italy
Cardiovascular risk; apolipoproteins; Mediterranean diet; vegetarian diet
ISSN:1743-7075, 1743-7075
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Shrnutí:Background Apolipoproteins have been recently proposed as novel markers of cardiovascular disease (CVD) risk. However, evidence regarding effects of diet on apolipoproteins is limited. Aim To compare the effects of Mediterranean diet (MD) and lacto-ovo vegetarian diet (VD) on apolipoproteins and traditional CVD risk factors in participants with low-to-moderate CVD risk. Methods Fifty-two participants (39 women; 49.1 ± 12.4 years), followed MD and VD for 3 months each. Medical and dietary information was collected at the baseline. Anthropometric parameters and blood samples were obtained at the beginning and the end of interventions. Results MD and VD resulted in significant improvement in anthropometric and lipid profiles. Both diets led to a reduction in most of the inflammatory parameters. As for apolipoproteins, a significant change was observed for ApoC-I after VD (+ 24.4%; p  = 0.020). MD led to a negative correlation between ApoC-III and carbohydrates (R = − 0.29; p  = 0.039) whereas VD between ApoD and saturated fats (R = − 0.38; p  = 0.006). A positive correlation emerged after VD between HDL and ApoD (R = 0.33; p  = 0.017) and after MD between plasma triglycerides and ApoC-I (R = 0.32; p  = 0.020) and ApoD (R = 0.30; p  = 0.031). IL-17 resulted to be positively correlated with ApoB after MD (R = 0.31; p  = 0.028) and with ApoC-III after VD (R = 0.32; p  = 0.019). Subgroup analysis revealed positive effects on apolipoproteins from both diets, especially in women, individuals older than 50 years-old or with < 3 CVD risk factors. Conclusions Both diets seem to improve CVD risk, however, MD showed a greater positive effect on apolipoproteins in some subgroups, thus suggesting how diet may influence new potential markers of CVD risk. Trial registration : registered at clinicaltrials.gov (identifier: NCT02641834) on December 2015.
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ISSN:1743-7075
1743-7075
DOI:10.1186/s12986-023-00773-w