Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Most eukaryotes harbor two distinct pre-mRNA splicing machineries: the major spliceosome, which removes >99% of introns, and the minor spliceosome, which removes rare, evolutionarily conserved introns. Although hypothesized to serve important regulatory functions, physiologic roles of the minor s...

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Published in:	Nature genetics Vol. 53; no. 5; pp. 707 - 718
Main Authors:	Inoue, Daichi, Polaski, Jacob T., Taylor, Justin, Castel, Pau, Chen, Sisi, Kobayashi, Susumu, Hogg, Simon J., Hayashi, Yasutaka, Pineda, Jose Mario Bello, El Marabti, Ettaib, Erickson, Caroline, Knorr, Katherine, Fukumoto, Miki, Yamazaki, Hiromi, Tanaka, Atsushi, Fukui, Chie, Lu, Sydney X., Durham, Benjamin H., Liu, Bo, Wang, Eric, Mehta, Sanjoy, Zakheim, Daniel, Garippa, Ralph, Penson, Alex, Chew, Guo-Liang, McCormick, Frank, Bradley, Robert K., Abdel-Wahab, Omar
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2021 Nature Publishing Group
Subjects:	38/91 45/70 45/91 631/337/2019 64 64/60 692/699/67/1990 692/699/67/1990/1673 692/699/67/1990/283 692/699/67/71 96/100 96/31 Agriculture Animal Genetics and Genomics Animals Base Sequence Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Cell Self Renewal Cell Transformation, Neoplastic - pathology Clone Cells CRISPR CRISPR-Cas Systems - genetics Development and progression Eukaryotes Female Females Gene Function Genes Genetic aspects Genetic Predisposition to Disease Genetic susceptibility Genome, Human Health aspects Hematologic Diseases - genetics Hematologic Diseases - pathology Hematopoiesis Hematopoietic stem cells Hematopoietic Stem Cells - metabolism Human Genetics Humans Introns Introns - genetics Leukemia Male Mice Mice, Knockout Mimicry mRNA mRNA turnover Mutation Myelodysplastic syndromes Neoplasms - genetics Noonan Syndrome - genetics Noonan's syndrome Oncology, Experimental Pedigree Proteins Retention Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA - metabolism RNA splicing RNA Splicing - genetics Solid tumors Spleen - pathology Splicing Stem cells Transcription Factors - genetics Tumors X chromosomes Japan
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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