Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal...

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Bibliographic Details
Published in:Advanced healthcare materials Vol. 5; no. 7; pp. 781 - 785
Main Authors: Lee, Jung Bok, Wang, Xintong, Faley, Shannon, Baer, Bradly, Balikov, Daniel A., Sung, Hak-Joon, Bellan, Leon M.
Format: Journal Article
Language:English
Published: Germany Blackwell Publishing Ltd 06.04.2016
Wiley Subscription Services, Inc
Subjects:
Acrylic Resins - pharmacology
artificial vasculature
Constants
Dermis - cytology
Encapsulation
Fibroblasts
Fibroblasts - cytology
Fibroblasts - drug effects
Gelatin - pharmacology
gelatin hydrogel
Gelatins
Humans
Hydrogels
Hydrogels - pharmacology
Imaging, Three-Dimensional
Infant, Newborn
Microfibers
Microscopy, Confocal
Microvessels - drug effects
Networks
Perfusion
poly(N-isopropylacrylamide)
Temperature
Three dimensional
tissue engineering
poly(N-isopropylacrylamide)
tissue engineering
gelatin hydrogel
artificial vasculature
microfibers
ISSN:2192-2640, 2192-2659, 2192-2659
Online Access:Get full text
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Summary:A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.
Bibliography:ark:/67375/WNG-QMK1T3GT-N
ArticleID:ADHM201500792
istex:408F09565DF633A890CCC82D9AA764C919DAAD75
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
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ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.201500792