Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers

A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal...

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Vydáno v:Advanced healthcare materials Ročník 5; číslo 7; s. 781 - 785
Hlavní autoři: Lee, Jung Bok, Wang, Xintong, Faley, Shannon, Baer, Bradly, Balikov, Daniel A., Sung, Hak-Joon, Bellan, Leon M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Germany Blackwell Publishing Ltd 06.04.2016
Wiley Subscription Services, Inc
Témata:
Acrylic Resins - pharmacology
artificial vasculature
Constants
Dermis - cytology
Encapsulation
Fibroblasts
Fibroblasts - cytology
Fibroblasts - drug effects
Gelatin - pharmacology
gelatin hydrogel
Gelatins
Humans
Hydrogels
Hydrogels - pharmacology
Imaging, Three-Dimensional
Infant, Newborn
Microfibers
Microscopy, Confocal
Microvessels - drug effects
Networks
Perfusion
poly(N-isopropylacrylamide)
Temperature
Three dimensional
tissue engineering
poly(N-isopropylacrylamide)
tissue engineering
gelatin hydrogel
artificial vasculature
microfibers
ISSN:2192-2640, 2192-2659, 2192-2659
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Shrnutí:A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N‐isopropylacrylamide) microfibers. The capillary‐like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.
Bibliografie:ark:/67375/WNG-QMK1T3GT-N
ArticleID:ADHM201500792
istex:408F09565DF633A890CCC82D9AA764C919DAAD75
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.201500792