Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial

Long-term hormone therapy has been the standard of care for advanced prostate cancer since the 1940s. STAMPEDE is a randomised controlled trial using a multiarm, multistage platform design. It recruits men with high-risk, locally advanced, metastatic or recurrent prostate cancer who are starting fir...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 387; no. 10024; pp. 1163 - 1177
Main Authors:	James, Nicholas D, Sydes, Matthew R, Clarke, Noel W, Mason, Malcolm D, Dearnaley, David P, Spears, Melissa R, Ritchie, Alastair W S, Parker, Christopher C, Russell, J Martin, Attard, Gerhardt, de Bono, Johann, Cross, William, Jones, Rob J, Thalmann, George, Amos, Claire, Matheson, David, Millman, Robin, Alzouebi, Mymoona, Beesley, Sharon, Birtle, Alison J, Brock, Susannah, Cathomas, Richard, Chakraborti, Prabir, Chowdhury, Simon, Cook, Audrey, Elliott, Tony, Gale, Joanna, Gibbs, Stephanie, Graham, John D, Hetherington, John, Hughes, Robert, Laing, Robert, McKinna, Fiona, McLaren, Duncan B, O'Sullivan, Joe M, Parikh, Omi, Peedell, Clive, Protheroe, Andrew, Robinson, Angus J, Srihari, Narayanan, Srinivasan, Rajaguru, Staffurth, John, Sundar, Santhanam, Tolan, Shaun, Tsang, David, Wagstaff, John, Parmar, Mahesh K B
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 19.03.2016 Elsevier Limited Elsevier
Subjects:	Adult Aged Aged, 80 and over Androgen Antagonists - administration & dosage Androgen Antagonists - adverse effects Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer therapies Clinical trials Diphosphonates - administration & dosage Diphosphonates - adverse effects Disease Progression Docetaxel Drug Administration Schedule Heterogeneity Hormone replacement therapy Humans Imidazoles - administration & dosage Imidazoles - adverse effects Internal Medicine Kaplan-Meier Estimate Male Medical prognosis Medical research Metastasis Middle Aged Neoplasm Metastasis Prostate cancer Prostatic Neoplasms - drug therapy Statistical analysis Survival Survival analysis Taxoids - administration & dosage Taxoids - adverse effects Treatment Outcome Zoledronic Acid
ISSN:	0140-6736, 1474-547X
Online Access:	Get full text
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