DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice

Senescent vascular smooth muscle cells (VSMCs) accumulate in the vasculature with age and tissue damage and secrete factors that promote atherosclerotic plaque vulnerability and disease. Here, we report increased levels and activity of dipeptidyl peptidase 4 (DPP4), a serine protease, in senescent V...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 133; no. 12; pp. 1 - 18
Main Authors:	Herman, Allison B., Tsitsipatis, Dimitrios, Anerillas, Carlos, Mazan-Mamczarz, Krystyna, Carr, Angelica E., Gregg, Jordan M., Wang, Mingyi, Zhang, Jing, Michel, Marc, Henry-Smith, Charnae’ A., Harris, Sophia C., Munk, Rachel, Martindale, Jennifer L., Piao, Yulan, Fan, Jinshui, Mattison, Julie A., De, Supriyo, Abdelmohsen, Kotb, Maul, Robert W., Tanaka, Toshiko, Moore, Ann Zenobia, DeMouth, Megan E., Sidoli, Simone, Ferrucci, Luigi, Liu, Yie, de Cabo, Rafael, Lakatta, Edward G., Gorospe, Myriam
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.06.2023
Subjects:	Aging Arteriosclerosis Atherosclerosis Biomedical research Blood circulation disorders Cardiovascular diseases Care and treatment Cell cycle Cell death Cells Coagulation factors Development and progression Diabetes Disease Disease susceptibility Fibroblasts Genotype & phenotype Health aspects Hemostasis Hypoxia Inflammation Kinases Muscle cells Phenotypes Protease inhibitors Proteins Scientific equipment and supplies industry Senescence Serine proteinase Smooth muscle Testing Thrombin Type 2 diabetes Vascular biology Vascular diseases Vascular smooth muscle United States Maryland Aging Vascular Biology Atherosclerosis Cellular senescence
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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