PD-1 blockade inhibits osteoclast formation and murine bone cancer pain

Emerging immune therapy, such as with the anti-programmed cell death-1 (anti-PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with terminal cancer suffer from cancer pain as a result of bone metastasis and bone destruction, but how PD-1 blockade affects bone can...

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Veröffentlicht in:	The Journal of clinical investigation Jg. 130; H. 7; S. 3603 - 3620
Hauptverfasser:	Wang, Kaiyuan, Gu, Yun, Liao, Yihan, Bang, Sangsu, Donnelly, Christopher R., Chen, Ouyang, Tao, Xueshu, Mirando, Anthony J., Hilton, Matthew J., Ji, Ru-Rong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States American Society for Clinical Investigation 01.07.2020
Schlagworte:	Animals Antibodies Apoptosis Biomedical research Bone cancer Bone growth Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cancer metastasis Cancer pain Cancer Pain - drug therapy Cancer Pain - genetics Cancer Pain - metabolism Cancer Pain - pathology Cancer prevention Cancer therapies Carcinoma, Lewis Lung - drug therapy Carcinoma, Lewis Lung - genetics Carcinoma, Lewis Lung - metabolism Carcinoma, Lewis Lung - pathology CCR2 protein Cell death Cold Comparative analysis Development and progression Female Fractures Gender differences Immunotherapy Inoculation Lung cancer Melanoma Metastases Metastasis Mice Mice, Knockout Monoclonal antibodies Monocyte chemoattractant protein 1 Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nivolumab Nivolumab - pharmacology Osteoclastogenesis Osteoclasts - metabolism Osteoclasts - pathology Pain Pain management PD-1 protein PD-L1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - metabolism Rodents Sensory neurons Skin cancer Targeted cancer therapy TRANCE protein Tumor suppression Neuroscience Bone disease Pain Cancer Cell Biology
ISSN:	0021-9738, 1558-8238, 1558-8238
Online-Zugang:	Volltext
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