Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation

Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain elusive. Here we identified adipocyte-secreted mi...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 129; no. 2; pp. 834 - 849
Main Authors:	Pan, Yong, Hui, Xiaoyan, Hoo, Ruby Lai Chong, Ye, Dewei, Chan, Cyrus Yuk Cheung, Feng, Tianshi, Wang, Yu, Lam, Karen Siu Ling, Xu, Aimin
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.02.2019
Subjects:	Adipocytes Adipocytes - metabolism Adipocytes - pathology Adipose tissue Animals Apoptosis Biomedical research Body weight Bone marrow Complications and side effects Cytokines Diabetes Ectopic expression Exosomes Exosomes - genetics Exosomes - metabolism Exosomes - pathology Fat cells Gene expression Genetic aspects Glucose Glucose tolerance Homeostasis Inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Insulin Insulin resistance Intolerance Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology KLF4 protein Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Macrophages Macrophages - metabolism Macrophages - pathology Metabolism Metabolites Mice Mice, Knockout MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Obesity Obesity - genetics Obesity - metabolism Obesity - pathology Overweight Panniculitis - genetics Panniculitis - metabolism Panniculitis - pathology Paracrine signalling Phenotypes Polarization Risk factors Obesity Inflammation Adipose tissue Macrophages Metabolism
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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