Lipid-induced endothelial vascular cell adhesion molecule 1 promotes nonalcoholic steatohepatitis pathogenesis

Monocyte homing to the liver and adhesion to the liver sinusoidal endothelial cells (LSECs) are key elements in nonalcoholic steatohepatitis (NASH) pathogenesis. We reported previously that VCAM-1 mediates monocyte adhesion to LSECs. However, the pathogenic role of VCAM-1 in NASH is unclear. Herein,...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 131; no. 6; pp. 1 - 16
Main Authors:	Furuta, Kunimaro, Guo, Qianqian, Pavelko, Kevin D., Lee, Jeong-Heon, Robertson, Keith D., Nakao, Yasuhiko, Melek, Jan, Shah, Vijay H., Hirsova, Petra, Ibrahim, Samar H.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.03.2021
Subjects:	Animals Antibodies, Neutralizing - administration & dosage Atherosclerosis Biomedical research Cell adhesion & migration Cell adhesion molecules Chromatin Cytometry Development and progression Diet Disease Models, Animal Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Fatty acids Fatty liver Gene expression Gene Expression Profiling Genes Genomes Health aspects Hepatocytes Humans Inflammation Kinases Liver - drug effects Liver - metabolism Liver - pathology Liver diseases MAP kinase MAP kinase kinase MAP Kinase Signaling System - drug effects Mice Mice, Inbred C57BL Mice, Knockout Monocytes Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Palmitates - toxicity Palmitic acid Pathogenesis Physiological aspects Protein expression Proteins RNA, Messenger - genetics Transcription Transcriptomes Up-Regulation - drug effects Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - antagonists & inhibitors Vascular Cell Adhesion Molecule-1 - genetics Vascular Cell Adhesion Molecule-1 - metabolism United States Cell migration/adhesion Hepatology Endothelial cells
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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