Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor

Germ cell tumors (GCTs) are the most common cancer in men between the ages of 15 and 40. Although most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes. One in every 17 patients with primary mediastinal nonseminomatous GCTs develop an incurable hematolo...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 130; no. 12; pp. 6668 - 6676
Main Authors:	Taylor, Justin, Donoghue, Mark T.A., Ho, Caleb, Petrova-Drus, Kseniya, Al-Ahmadie, Hikmat A., Funt, Samuel A., Zhang, Yanming, Aypar, Umut, Rao, Pavitra, Chavan, Shweta S., Haddadin, Michael, Tamari, Roni, Giralt, Sergio, Tallman, Martin S., Rampal, Raajit K., Baez, Priscilla, Kappagantula, Rajya, Kosuri, Satyajit, Dogan, Ahmet, Tickoo, Satish K., Reuter, Victor E., Bosl, George J., Iacobuzio-Donahue, Christine A., Solit, David B., Taylor, Barry S., Feldman, Darren R., Abdel-Wahab, Omar
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.12.2020
Subjects:	Adolescent Adult Biomedical research Blood cancer Cancer therapies Care and treatment Chemotherapy Cloning Deoxyribonucleic acid Development and progression DNA Evolution & development Female Gene expression Gene mutation Genetic aspects Genotypes Germinoma Health aspects Hematologic Neoplasms - genetics Hematologic Neoplasms - metabolism Hematologic Neoplasms - pathology Hematological diseases Histology Humans Identification and classification Leukemia Malignancy Mediastinum Medical prognosis Middle Aged Mutation Neoplasms, Germ Cell and Embryonal - genetics Neoplasms, Germ Cell and Embryonal - metabolism Neoplasms, Germ Cell and Embryonal - pathology Neoplasms, Second Primary - genetics Neoplasms, Second Primary - metabolism Neoplasms, Second Primary - pathology p53 Protein Patients Signal Transduction - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors United States Genetics Hematology Leukemias Cancer
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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