mRNA therapeutics in cancer immunotherapy

Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment or peptide and lends itself to a broad range of pharmaceutical applications, including different modalities of cancer immunotherapy. With the ease of rapid, large scale Good Manufacturing Practice-grade mRNA...

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Bibliographic Details
Published in:	Molecular cancer Vol. 20; no. 1; pp. 69 - 24
Main Authors:	Beck, Jan D., Reidenbach, Daniel, Salomon, Nadja, Sahin, Ugur, Türeci, Özlem, Vormehr, Mathias, Kranz, Lena M.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.04.2021 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	2021 mRNA Special Issue Adjuvanticity Animals Antibodies Antibodies - genetics Antibodies - immunology Antigen Presentation - immunology Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antiviral agents Antiviral drugs Basiliximab Biomarkers, Tumor Biomedical and Life Sciences Biomedicine Cancer Cancer immunotherapy Cancer Research Cancer vaccines Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology Care and treatment Chimeric antigen receptors Cytokines - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Double-stranded RNA Drug therapy Genetic Therapy - methods Health aspects Humans Immune response Immunization Immunologic Factors - genetics Immunomodulation Immunomodulators Immunomodulatory proteins Immunoreceptors Immunotherapy Immunotherapy - methods Innate immunity Kinases Lymphatic system Lymphocytes T Messenger RNA mRNA Nanoparticles Neoantigens Neoplasms - etiology Neoplasms - pathology Neoplasms - therapy Nucleosides Oncology Pattern recognition receptors Pharmacodynamics Pharmacokinetics Prostate cancer Protein biosynthesis Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Recombinant proteins Review RNA, Messenger - administration & dosage RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - immunology T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Tetanus antitoxin Transfection Tumor antigens Vaccination Vaccines Viral antibodies Cancer vaccines Immunoreceptors CARs Messenger RNA Antibodies Cancer immunotherapy Immunomodulatory proteins
ISSN:	1476-4598, 1476-4598
Online Access:	Get full text
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