Patient-derived xenograft (PDX) models, applications and challenges in cancer research

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of...

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Veröffentlicht in:Journal of translational medicine Jg. 20; H. 1; S. 206 - 15
Hauptverfasser: Abdolahi, Shahrokh, Ghazvinian, Zeinab, Muhammadnejad, Samad, Saleh, Mahshid, Asadzadeh Aghdaei, Hamid, Baghaei, Kaveh
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London BioMed Central 10.05.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Schlagworte:
Animal models in research
Animals
Antitumor agents
Avatar model of cancer
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer animal model
Cancer microenvironment
Cancer research
Cancer therapies
Chemotherapy
Clinical trials
COVID-19
Disease Models, Animal
Drug development
Drugs
Gene expression
Heterografts
Humanized model
Humans
Immune system
Immunotherapy
Medical research
Medicine/Public Health
Neoplasms - pathology
Patient outcomes
Patients
PDX
Precision medicine
Precision Medicine - methods
Preclinical study
Prevention
Review
Success
Transplants & implants
Tumor Microenvironment
Tumors
Validity
Xenograft Model Antitumor Assays
Xenografts
Xenotransplantation
United States
Preclinical study
Humanized model
PDX
Cancer animal model
Avatar model of cancer
ISSN:1479-5876, 1479-5876
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Zusammenfassung:The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
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ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03405-8