Patient-derived xenograft (PDX) models, applications and challenges in cancer research

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 20; no. 1; pp. 206 - 15
Main Authors:	Abdolahi, Shahrokh, Ghazvinian, Zeinab, Muhammadnejad, Samad, Saleh, Mahshid, Asadzadeh Aghdaei, Hamid, Baghaei, Kaveh
Format:	Journal Article
Language:	English
Published:	London BioMed Central 10.05.2022 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Animal models in research Animals Antitumor agents Avatar model of cancer Biomedical and Life Sciences Biomedicine Cancer Cancer animal model Cancer microenvironment Cancer research Cancer therapies Chemotherapy Clinical trials COVID-19 Disease Models, Animal Drug development Drugs Gene expression Heterografts Humanized model Humans Immune system Immunotherapy Medical research Medicine/Public Health Neoplasms - pathology Patient outcomes Patients PDX Precision medicine Precision Medicine - methods Preclinical study Prevention Review Success Transplants & implants Tumor Microenvironment Tumors Validity Xenograft Model Antitumor Assays Xenografts Xenotransplantation United States Preclinical study Humanized model PDX Cancer animal model Avatar model of cancer
ISSN:	1479-5876, 1479-5876
Online Access:	Get full text
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