Patient-derived xenograft (PDX) models, applications and challenges in cancer research

The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of...

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Vydáno v:Journal of translational medicine Ročník 20; číslo 1; s. 206 - 15
Hlavní autoři: Abdolahi, Shahrokh, Ghazvinian, Zeinab, Muhammadnejad, Samad, Saleh, Mahshid, Asadzadeh Aghdaei, Hamid, Baghaei, Kaveh
Médium: Journal Article
Jazyk:angličtina
Vydáno: London BioMed Central 10.05.2022
BioMed Central Ltd
Springer Nature B.V
BMC
Témata:
Animal models in research
Animals
Antitumor agents
Avatar model of cancer
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer animal model
Cancer microenvironment
Cancer research
Cancer therapies
Chemotherapy
Clinical trials
COVID-19
Disease Models, Animal
Drug development
Drugs
Gene expression
Heterografts
Humanized model
Humans
Immune system
Immunotherapy
Medical research
Medicine/Public Health
Neoplasms - pathology
Patient outcomes
Patients
PDX
Precision medicine
Precision Medicine - methods
Preclinical study
Prevention
Review
Success
Transplants & implants
Tumor Microenvironment
Tumors
Validity
Xenograft Model Antitumor Assays
Xenografts
Xenotransplantation
United States
Preclinical study
Humanized model
PDX
Cancer animal model
Avatar model of cancer
ISSN:1479-5876, 1479-5876
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
AbstractList The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
Abstract The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations.
The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies. Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment. These features have made it a reliable model along with the development of humanized models. Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks. This review summarizes patient-derived xenograft models development procedures, drug development applications in various cancers, challenges and limitations. Keywords: Cancer animal model, PDX, Preclinical study, Humanized model, Avatar model of cancer
ArticleNumber 206
Audience Academic
Author Saleh, Mahshid
Muhammadnejad, Samad
Baghaei, Kaveh
Asadzadeh Aghdaei, Hamid
Abdolahi, Shahrokh
Ghazvinian, Zeinab
Author_xml – sequence: 1
  givenname: Shahrokh
  surname: Abdolahi
  fullname: Abdolahi, Shahrokh
  organization: Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences
– sequence: 2
  givenname: Zeinab
  surname: Ghazvinian
  fullname: Ghazvinian, Zeinab
  organization: Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences
– sequence: 3
  givenname: Samad
  surname: Muhammadnejad
  fullname: Muhammadnejad, Samad
  organization: Cell-Based Therapies Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences
– sequence: 4
  givenname: Mahshid
  surname: Saleh
  fullname: Saleh, Mahshid
  organization: Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences
– sequence: 5
  givenname: Hamid
  surname: Asadzadeh Aghdaei
  fullname: Asadzadeh Aghdaei, Hamid
  organization: Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences
– sequence: 6
  givenname: Kaveh
  orcidid: 0000-0003-2102-9729
  surname: Baghaei
  fullname: Baghaei, Kaveh
  email: kavehbaghai@gmail.com
  organization: Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35538576$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Preclinical study
Humanized model
PDX
Cancer animal model
Avatar model of cancer
Language English
License 2022. The Author(s).
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Snippet The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical studies....
Abstract The establishing of the first cancer models created a new perspective on the identification and evaluation of new anti-cancer therapies in preclinical...
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StartPage 206
SubjectTerms Animal models in research
Animals
Antitumor agents
Avatar model of cancer
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer animal model
Cancer microenvironment
Cancer research
Cancer therapies
Chemotherapy
Clinical trials
COVID-19
Disease Models, Animal
Drug development
Drugs
Gene expression
Heterografts
Humanized model
Humans
Immune system
Immunotherapy
Medical research
Medicine/Public Health
Neoplasms - pathology
Patient outcomes
Patients
PDX
Precision medicine
Precision Medicine - methods
Preclinical study
Prevention
Review
Success
Transplants & implants
Tumor Microenvironment
Tumors
Validity
Xenograft Model Antitumor Assays
Xenografts
Xenotransplantation
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Title Patient-derived xenograft (PDX) models, applications and challenges in cancer research
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Volume 20
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