A phase Ib/II randomized, open-label drug repurposing trial of glutamate signaling inhibitors in combination with chemoradiotherapy in patients with newly diagnosed glioblastoma: the GLUGLIO trial protocol

Background Glioblastoma is the most common and most aggressive malignant primary brain tumor in adults. Glioblastoma cells synthesize and secrete large quantities of the excitatory neurotransmitter glutamate, driving epilepsy, neuronal death, tumor growth and invasion. Moreover, neuronal networks in...

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Bibliographic Details
Published in:	BMC cancer Vol. 24; no. 1; pp. 82 - 7
Main Authors:	Mastall, Maximilian, Roth, Patrick, Bink, Andrea, Fischer Maranta, Angela, Läubli, Heinz, Hottinger, Andreas Felix, Hundsberger, Thomas, Migliorini, Denis, Ochsenbein, Adrian, Seystahl, Katharina, Imbach, Lukas, Hortobagyi, Tibor, Held, Leonhard, Weller, Michael, Wirsching, Hans-Georg
Format:	Journal Article
Language:	English
Published:	London BioMed Central 15.01.2024 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Amino acids Analysis Antibiotics Anticonvulsants Biomedical and Life Sciences Biomedicine Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - genetics Brain tumors Calcium signalling Cancer neuroscience Cancer Research Cancer therapies Care and treatment Caregivers Chemoradiotherapy Chemotherapy Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Cognitive ability Convulsions & seizures Diagnosis DNA methylation DNA methyltransferase Dosage and administration Drug development Drug dosages Drug Repositioning EEG Electroencephalography Epilepsy Gabapentin Gap junctions Glioblastoma Glioblastoma - drug therapy Glioblastoma - genetics Glioblastoma cells Glioblastoma multiforme Glutamate Glutamatergic transmission Glutamates Health Promotion and Disease Prevention Humans Magnetic resonance imaging Magnetic resonance spectroscopy Medicine/Public Health Memantine Methylation Methylguanine Multicenter Studies as Topic Neural networks Neuroimaging Neurons Nuclear magnetic resonance spectroscopy O6-methylguanine-DNA methyltransferase Oncology Patients Quality of Life Questionnaires Radiation therapy Randomized Controlled Trials as Topic Seizures Seizures (Medicine) Standard of care Steroids - therapeutic use Study Protocol Sulfasalazine Surgical Oncology Synapses Temozolomide Testing Toxicity Tumor cells Switzerland Cancer neuroscience Sulfasalazine Memantine Gabapentin Epilepsy
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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