Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments

Th cells integrate signals from their microenvironment to acquire distinct specialization programs for efficient clearance of diverse pathogens or for immunotolerance. Ionic signals have recently been demonstrated to affect T cell polarization and function. Sodium chloride (NaCl) was proposed to acc...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 130; no. 9; pp. 4587 - 4600
Main Authors:	Matthias, Julia, Heink, Sylvia, Picard, Felix, Zeiträg, Julia, Kolz, Anna, Chao, Ying-Yin, Soll, Dominik, de Almeida, Gustavo P., Glasmacher, Elke, Jacobsen, Ilse D., Riedel, Thomas, Peters, Anneli, Floess, Stefan, Huehn, Jochen, Baumjohann, Dirk, Huber, Magdalena, Korn, Thomas, Zielinski, Christina E.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.09.2020
Subjects:	Animals Anti-inflammatory agents Autoimmunity Biomedical research Bone morphogenetic proteins Cell fate Cellular Microenvironment - drug effects Cellular Microenvironment - immunology Cloning Cytokines Cytokines - genetics Cytokines - immunology Dietary intake Experimental allergic encephalomyelitis Foxp3 protein Genotype & phenotype Helper cells Humans Immunological tolerance Inflammation - genetics Inflammation - immunology Inflammation - pathology Inflammatory diseases Lymphocytes Lymphocytes T MAP kinase MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - genetics MAP Kinase Signaling System - immunology Mice Mice, Transgenic Microenvironments Pathogenicity Pathogens Scientific equipment industry Sodium chloride Sodium Chloride, Dietary - pharmacology Software industry Specialization T cell receptors T cells Th17 Cells - immunology Th17 Cells - pathology Transforming growth factors United States Germany Adaptive immunity Inflammation Immunology T cells
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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