The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARS-CoV-2 infection. Here, we utilized proteomics, RNA sequencing, autoantibody arrays, and B cell receptor (BCR) repertoire analysis...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 131; no. 20; pp. 1 - 17
Main Authors:	Porritt, Rebecca A., Binek, Aleksandra, Paschold, Lisa, Rivas, Magali Noval, McArdle, Angela, Yonker, Lael M., Alter, Galit, Chandnani, Harsha K., Lopez, Merrick, Fasano, Alessio, Van Eyk, Jennifer E., Binder, Mascha, Arditi, Moshe
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 15.10.2021
Subjects:	Adaptive Immunity Adolescent Antigens Autoantibodies Autoimmunity B-cell receptor Biomarkers Biomarkers - metabolism Biomedical research Case-Control Studies Cell activation Child Child, Preschool Children Cohort Studies Complement activation Coronaviruses COVID-19 COVID-19 - complications COVID-19 - genetics COVID-19 - immunology COVID-19 - metabolism Cytokine Release Syndrome - immunology Cytokine storm Disease Female Genetic aspects Health aspects Humans Immune response Immune response (humoral) Immunoglobulin G Immunopathogenesis Infant Inflammation Inflammation - immunology Intensive care Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Male Mucocutaneous Lymph Node Syndrome - genetics Mucocutaneous Lymph Node Syndrome - immunology Mucocutaneous Lymph Node Syndrome - metabolism Multisystem inflammatory syndrome in children Neutrophil Activation Neutrophils Pandemics Pathogenesis Patients Pediatric research Pediatrics Peptides Plasma Proteins Proteomics Receptors, Antigen, B-Cell - genetics RNA-Seq Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Systemic Inflammatory Response Syndrome - genetics Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - metabolism T cell receptors Variable region United States COVID-19 Inflammation Cytokines Autoimmune diseases Cellular immune response
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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