Metabolic dysfunction-associated fatty liver disease and implications for cardiovascular risk and disease prevention

The newly proposed term “metabolic dysfunction-associated fatty liver disease” (MAFLD) is replacing the old term “non-alcoholic fatty liver disease” (NAFLD) in many global regions, because it better reflects the pathophysiology and cardiometabolic implications of this common liver disease. The propo...

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Vydané v:Cardiovascular diabetology Ročník 21; číslo 1; s. 270 - 17
Hlavní autori: Zhou, Xiao-Dong, Cai, Jingjing, Targher, Giovanni, Byrne, Christopher D., Shapiro, Michael D., Sung, Ki-Chul, Somers, Virend K., Chahal, C. Anwar A., George, Jacob, Chen, Li-Li, Zhou, Yong, Zheng, Ming-Hua
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 03.12.2022
Springer Nature B.V
BMC
Predmet:
Angiology
Cardiology
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
Cohort analysis
Diabetes
Fatty liver
Heart attacks
Heart Disease Risk Factors
Hepatitis
Humans
Liver diseases
Medicine
Medicine & Public Health
Metabolic dysfunction-associated fatty liver disease (MAFLD)
Metabolism
Morbidity
Mortality
Non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic Fatty Liver Disease - diagnosis
Non-alcoholic Fatty Liver Disease - epidemiology
Pharmacotherapies
Review
Risk Factors
Stroke
Terminology
Pharmacotherapies
Metabolic dysfunction-associated fatty liver disease (MAFLD)
Cardiovascular disease
Risk factors
Non-alcoholic fatty liver disease (NAFLD)
ISSN:1475-2840, 1475-2840
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Popis
Shrnutí:The newly proposed term “metabolic dysfunction-associated fatty liver disease” (MAFLD) is replacing the old term “non-alcoholic fatty liver disease” (NAFLD) in many global regions, because it better reflects the pathophysiology and cardiometabolic implications of this common liver disease. The proposed change in terminology from NAFLD to MAFLD is not simply a single-letter change in an acronym, since MAFLD is defined by a set of specific and positive diagnostic criteria. In particular, the MAFLD definition specifically incorporates within the classification recognized cardiovascular risk factors. Although convincing evidence supports a significant association between both NAFLD and MAFLD, with increased risk of CVD morbidity and mortality, neither NAFLD nor MAFLD have received sufficient attention from the Cardiology community. In fact, there is a paucity of scientific guidelines focusing on this common and burdensome liver disease from cardiovascular professional societies. This Perspective article discusses the rationale and clinical relevance for Cardiologists of the newly proposed MAFLD definition.
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ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-022-01697-0