Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study

Background Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were invest...

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Bibliographic Details
Published in:Cardiovascular diabetology Vol. 20; no. 1; pp. 231 - 12
Main Authors: Chevli, Parag Anilkumar, Freedman, Barry I., Hsu, Fang-Chi, Xu, Jianzhao, Rudock, Megan E., Ma, Lijun, Parks, John S., Palmer, Nicholette D., Shapiro, Michael D.
Format: Journal Article
Language:English
Published: London BioMed Central 07.12.2021
Springer Nature B.V
BMC
Subjects:
African Americans
Aged
Amino acids
Angiology
Angioplasty
Arteriosclerosis
Asymptomatic Diseases
Atherosclerosis
Biomarkers
Biomarkers - blood
Black or African American
Blood pressure
Calcification
Calcification (ectopic)
Cardiology
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Chromatography
Chromatography, Reverse-Phase
Computed tomography
Coronary artery
Coronary artery calcium
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - ethnology
Coronary vessels
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - ethnology
EKG
Ethnicity
European Americans
Fasting
Female
Heart surgery
High density lipoprotein
Humans
Hypertension
Lecithin
Lipids
Liquid chromatography
Low density lipoprotein
Male
Mass spectroscopy
Medicine
Medicine & Public Health
Metabolism
Metabolites
Metabolome
Metabolomics
Middle Aged
Mortality
North Carolina - epidemiology
Original Investigation
Phosphatidylcholine
Plasma
Predictive Value of Tests
Proteins
Risk Assessment
Risk Factors
Software
Spectrometry, Mass, Electrospray Ionization
Steroid hormones
Tandem Mass Spectrometry
Tomography
Veins & arteries
White People
North Carolina
African Americans
Metabolomics
Cardiovascular disease
Coronary artery calcium
Diabetes mellitus
European Americans
ISSN:1475-2840, 1475-2840
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Summary:Background Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were investigated in the Diabetes Heart Study (DHS), a cohort enriched for type 2 diabetes (T2D). Methods The analysis included 700 DHS participants, 438 African Americans (AAs), and 262 European Americans (EAs), in whom coronary artery calcium (CAC) was assessed using ECG-gated computed tomography. Plasma metabolomics using liquid chromatography-mass spectrometry identified 853 known metabolites. An ancestry-specific marginal model incorporating generalized estimating equations examined associations between metabolites and CAC (log-transformed (CAC + 1) as outcome measure). Models were adjusted for age, sex, BMI, diabetes duration, date of plasma collection, time between plasma collection and CT exam, low-density lipoprotein cholesterol (LDL-C), and statin use. Results At an FDR-corrected p-value < 0.05, 33 metabolites were associated with CAC in AAs and 36 in EAs. The androgenic steroids, fatty acid, phosphatidylcholine, and bile acid metabolism subpathways were associated with CAC in AAs, whereas fatty acid, lysoplasmalogen, and branched-chain amino acid (BCAA) subpathways were associated with CAC in EAs. Conclusions Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants.
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ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-021-01419-y