Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study

Background Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were invest...

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Vydáno v:	Cardiovascular diabetology Ročník 20; číslo 1; s. 231 - 12
Hlavní autoři:	Chevli, Parag Anilkumar, Freedman, Barry I., Hsu, Fang-Chi, Xu, Jianzhao, Rudock, Megan E., Ma, Lijun, Parks, John S., Palmer, Nicholette D., Shapiro, Michael D.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London BioMed Central 07.12.2021 Springer Nature B.V BMC
Témata:	African Americans Aged Amino acids Angiology Angioplasty Arteriosclerosis Asymptomatic Diseases Atherosclerosis Biomarkers Biomarkers - blood Black or African American Blood pressure Calcification Calcification (ectopic) Cardiology Cardiovascular disease Cardiovascular diseases Cholesterol Chromatography Chromatography, Reverse-Phase Computed tomography Coronary artery Coronary artery calcium Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - ethnology Coronary vessels Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - ethnology EKG Ethnicity European Americans Fasting Female Heart surgery High density lipoprotein Humans Hypertension Lecithin Lipids Liquid chromatography Low density lipoprotein Male Mass spectroscopy Medicine Medicine & Public Health Metabolism Metabolites Metabolome Metabolomics Middle Aged Mortality North Carolina - epidemiology Original Investigation Phosphatidylcholine Plasma Predictive Value of Tests Proteins Risk Assessment Risk Factors Software Spectrometry, Mass, Electrospray Ionization Steroid hormones Tandem Mass Spectrometry Tomography Veins & arteries White People North Carolina African Americans Metabolomics Cardiovascular disease Coronary artery calcium Diabetes mellitus European Americans
ISSN:	1475-2840, 1475-2840
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Popis
Shrnutí:	Background Incidence rates of cardiovascular disease (CVD) are increasing, partly driven by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are needed to enhance risk assessment and management. Plasma metabolite associations with subclinical atherosclerosis were investigated in the Diabetes Heart Study (DHS), a cohort enriched for type 2 diabetes (T2D). Methods The analysis included 700 DHS participants, 438 African Americans (AAs), and 262 European Americans (EAs), in whom coronary artery calcium (CAC) was assessed using ECG-gated computed tomography. Plasma metabolomics using liquid chromatography-mass spectrometry identified 853 known metabolites. An ancestry-specific marginal model incorporating generalized estimating equations examined associations between metabolites and CAC (log-transformed (CAC + 1) as outcome measure). Models were adjusted for age, sex, BMI, diabetes duration, date of plasma collection, time between plasma collection and CT exam, low-density lipoprotein cholesterol (LDL-C), and statin use. Results At an FDR-corrected p-value < 0.05, 33 metabolites were associated with CAC in AAs and 36 in EAs. The androgenic steroids, fatty acid, phosphatidylcholine, and bile acid metabolism subpathways were associated with CAC in AAs, whereas fatty acid, lysoplasmalogen, and branched-chain amino acid (BCAA) subpathways were associated with CAC in EAs. Conclusions Strikingly different metabolic signatures were associated with subclinical coronary atherosclerosis in AA and EA DHS participants.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1475-2840 1475-2840
DOI:	10.1186/s12933-021-01419-y