microRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance

A disequilibrium between immunosuppressive Tregs and inflammatory IL-17-producing Th17 cells is a hallmark of autoimmune diseases, including multiple sclerosis (MS). However, the molecular mechanisms underlying the Treg and Th17 imbalance in CNS autoimmunity remain largely unclear. Identifying the f...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 132; no. 10; pp. 1 - 16
Main Authors:	Fujiwara, Mai, Raheja, Radhika, Garo, Lucien P., Ajay, Amrendra K., Kadowaki-Saga, Ryoko, Karandikar, Sukrut H., Gabriely, Galina, Krishnan, Rajesh, Beynon, Vanessa, Paul, Anu, Patel, Amee, Saxena, Shrishti, Hu, Dan, Healy, Brian C., Chitnis, Tanuja, Gandhi, Roopali, Weiner, Howard L., Murugaiyan, Gopal
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 16.05.2022
Subjects:	Animals Autoimmune diseases Autoimmunity Biomedical research CD4 antigen Cell Differentiation Cellular control mechanisms Cytokines Development and progression Disease Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Experimental allergic encephalomyelitis FOXO1 protein Gene expression Genetic aspects Health aspects Helper cells Humans Inflammation Interleukin 17 Lymphocytes Lymphocytes T Mice Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - genetics miRNA Molecular modelling Multiple sclerosis Multiple Sclerosis - genetics Multiple Sclerosis - immunology Pathogenesis Patients T cells T-Lymphocytes, Regulatory Th1 Cells Th17 Cells Therapeutic targets Transcription factors United States Autoimmunity Multiple sclerosis Inflammation Autoimmune diseases T cells
ISSN:	1558-8238, 0021-9738, 1558-8238
Online Access:	Get full text
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