Metabolism of pancreatic cancer: paving the way to better anticancer strategies

Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic...

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Vydané v:Molecular cancer Ročník 19; číslo 1; s. 50 - 19
Hlavní autori: Qin, Cheng, Yang, Gang, Yang, Jinshou, Ren, Bo, Wang, Huanyu, Chen, Guangyu, Zhao, Fangyu, You, Lei, Wang, Weibin, Zhao, Yupei
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: London BioMed Central 02.03.2020
BioMed Central Ltd
Springer Nature B.V
BMC
Predmet:
Amino acids
Animals
Antineoplastic Agents - therapeutic use
Biomarkers, Tumor - metabolism
Biomedical and Life Sciences
Biomedicine
Biosynthesis
Cancer cells
Cancer Research
Cancer therapies
Cancer treatment
Carcinogenesis
Chemoresistance
Chemotherapy
Clinical trials
Dehydrogenases
Development and progression
Diseases
Drug therapy
Energy Metabolism
Enzymes
Gemcitabine
Gene expression
Glucose
Health aspects
Humans
Immunosuppression
Immunotherapy
Kinases
Lipids
Medical prognosis
Metabolic Networks and Pathways - drug effects
Metabolism
Methods
Mutation
Oncology
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - pathology
Patients
Physiological aspects
Radiation therapy
Radioresistance
Radiotherapy
Review
Tumors
United States > US
Immunosuppression
Gemcitabine
Pancreatic cancer
Chemoresistance
Clinical trials
Radioresistance
Metabolism
ISSN:1476-4598, 1476-4598
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Popis
Shrnutí:Pancreatic cancer is currently one of the most lethal diseases. In recent years, increasing evidence has shown that reprogrammed metabolism may play a critical role in the carcinogenesis, progression, treatment and prognosis of pancreatic cancer. Affected by internal or external factors, pancreatic cancer cells adopt extensively distinct metabolic processes to meet their demand for growth. Rewired glucose, amino acid and lipid metabolism and metabolic crosstalk within the tumor microenvironment contribute to unlimited pancreatic tumor progression. In addition, the metabolic reprogramming involved in pancreatic cancer resistance is also closely related to chemotherapy, radiotherapy and immunotherapy, and results in a poor prognosis. Reflective of the key role of metabolism, the number of preclinical and clinical trials about metabolism-targeted therapies for pancreatic cancer is increasing. The poor prognosis of pancreatic cancer patients might be largely improved after employing therapies that regulate metabolism. Thus, investigations of metabolism not only benefit the understanding of carcinogenesis and cancer progression but also provide new insights for treatments against pancreatic cancer.
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ISSN:1476-4598
1476-4598
DOI:10.1186/s12943-020-01169-7