Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis

•Screening of a large chemical library identified xanthines as PAD potential activators.•Deimination of human filaggrin was enhanced by caffeine, theobromine and acefylline.•Topical application of acefylline on reconstructed human epidermis improved deimination.•Acefylline is the first identified ac...

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Veröffentlicht in:	Journal of dermatological science Jg. 81; H. 2; S. 101 - 106
Hauptverfasser:	Méchin, Marie-Claire, Cau, Laura, Galliano, Marie-Florence, Daunes-Marion, Sylvie, Poigny, Stéphane, Vidaluc, Jean-Louis, Bessou-Touya, Sandrine, Takahara, Hidenari, Serre, Guy, Duplan, Hélène, Simon, Michel
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Ireland Ltd 01.02.2016 Elsevier
Schlagworte:	Administration, Cutaneous Cells, Cultured Computer Simulation Dermatology Dose-Response Relationship, Drug Enzyme Activation Enzyme Activators - administration & dosage Enzyme Activators - chemistry Enzyme Activators - pharmacology Epidermal barrier Epidermal Cells Epidermis / drug effects Epidermis - cytology Epidermis - drug effects Epidermis - enzymology Filaggrin Human health and pathology Humans Humans Hydrolases / metabolism Hydrolases - metabolism Infectious diseases Intermediate Filament Proteins - chemistry Intermediate Filament Proteins - metabolism Keratinocytes - drug effects Keratinocytes - enzymology Life Sciences Models, Molecular Post-translational modification Protein Conformation Protein Processing, Post-Translational Protein-Arginine Deiminases Skin Small Molecule Libraries Structure-Activity Relationship Theophylline - administration & dosage Theophylline - analogs & derivatives Theophylline - chemistry Theophylline - pharmacology Xanthine FLG Post-translational modification PAD Epidermal barrier LUT Skin Xanthine Filaggrin lookup table peptidylarginine deiminase filaggrin
ISSN:	0923-1811, 1873-569X, 1873-569X
Online-Zugang:	Volltext
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