Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics

Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but does not capture their spatial distribution nor reveal local networks of intercellular communication acting in situ. A suite of recently developed techniques that localize RNA within tissue, including multiplexed...

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Bibliographic Details
Published in:	Nature reviews. Genetics Vol. 22; no. 10; pp. 627 - 644
Main Authors:	Longo, Sophia K, Guo, Margaret G, Ji, Andrew L, Khavari, Paul A
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01.10.2021
Subjects:	Algorithms Animals Bar codes Cell Communication Communication Computational Biology - methods Computer applications Disease Gene expression Homeostasis Humans Hybridization Ligands Ribonucleic acid RNA Sequence Analysis, RNA - methods Single-Cell Analysis - methods Software Spatial data Spatial distribution Transcription Transcriptome Transcriptomes Transcriptomics
ISSN:	1471-0056, 1471-0064, 1471-0064
Online Access:	Get full text
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