Telomere Dynamics in Human Cells Reprogrammed to Pluripotency

Human induced pluripotent stem cells (IPSCs) have enormous potential in the development of cellular models of human disease and represent a potential source of autologous cells and tissues for therapeutic use. A question remains as to the biological age of IPSCs, in particular when isolated from old...

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Bibliographic Details
Published in:	PloS one Vol. 4; no. 12; p. e8124
Main Authors:	Suhr, Steven T., Chang, Eun Ah, Rodriguez, Ramon M., Wang, Kai, Ross, Pablo J., Beyhan, Zeki, Murthy, Shashanka, Cibelli, Jose B.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02.12.2009 Public Library of Science (PLoS)
Subjects:	Age Aged Aging Analysis Animal genetic engineering Animal sciences Autografts Cancer Cell culture Cell Differentiation Cell Line Cell lines Cellular Reprogramming - genetics Chromosomes Deoxyribonucleic acid Developmental Biology/Aging Developmental Biology/Cell Differentiation Developmental Biology/Embryology Developmental Biology/Stem Cells DNA Elongation Embryo cells Embryonic stem cells Embryos Explants Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Genetic Vectors - genetics Genomes Health aspects Heterogeneity Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Laboratories Lentivirus - genetics Male Microscopy, Phase-Contrast Phenotype Pluripotency Skin Somatic cells Stem cell transplantation Stem cells Telomerase Telomere - metabolism Telomeres Teratoma Teratoma - pathology Tissues Zoology United States > US East Lansing Michigan Michigan
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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