The Natural History of Biocatalytic Mechanisms

Phylogenomic analysis of the occurrence and abundance of protein domains in proteomes has recently showed that the α/β architecture is probably the oldest fold design. This holds important implications for the origins of biochemistry. Here we explore structure-function relationships addressing the u...

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Bibliographic Details
Published in:	PLoS computational biology Vol. 10; no. 5; p. e1003642
Main Authors:	Nath, Neetika, Mitchell, John B. O., Caetano-Anollés, Gustavo
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.05.2014 Public Library of Science (PLoS)
Subjects:	Architecture Biochemistry Biology and Life Sciences Catalysis Chemical reactions Classification Enzymes Enzymes - chemistry Enzymes - genetics Enzymes - ultrastructure Evolution Evolution, Molecular Metabolism Metabolites Phylogeny Physical Sciences Physiological aspects Protein Folding Protein research Protein Structure, Tertiary Proteins Structure-Activity Relationship
ISSN:	1553-7358, 1553-734X, 1553-7358
Online Access:	Get full text
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