Landscape of B cell immunity and related immune evasion in human cancers

Tumor-infiltrating B cells are an important component in the microenvironment but have unclear anti-tumor effects. We enhanced our previous computational algorithm TRUST to extract the B cell immunoglobulin hypervariable regions from bulk tumor RNA-sequencing data. TRUST assembled more than 30 milli...

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Veröffentlicht in:	Nature genetics Jg. 51; H. 3; S. 560 - 567
Hauptverfasser:	Hu, Xihao, Zhang, Jian, Wang, Jin, Fu, Jingxin, Li, Taiwen, Zheng, Xiaoqi, Wang, Binbin, Gu, Shengqing, Jiang, Peng, Fan, Jingyu, Ying, Xiaomin, Zhang, Jing, Carroll, Michael C., Wucherpfennig, Kai W., Hacohen, Nir, Zhang, Fan, Zhang, Peng, Liu, Jun S., Li, Bo, Liu, X. Shirley
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.03.2019 Nature Publishing Group
Schlagworte:	45/91 631/114/2164 631/114/794 631/250/580 631/67/327 631/67/580 Agriculture Algorithms Analysis Animal Genetics and Genomics Antibodies Antibody-dependent cell-mediated cytotoxicity Anticancer properties Antigens B cells B-Lymphocytes - immunology Base Sequence Bioinformatics Biomedical and Life Sciences Biomedicine Breast cancer Cancer Cancer genetics Cancer Research Care and treatment Cloning Complementarity Complementarity Determining Regions - immunology Complementarity-determining region Complementarity-determining region 3 Computer applications Copy number Cytotoxicity Gene Function Gene sequencing Genes Genomes Genomics Heavy chains Human Genetics Humans Immune evasion Immune Evasion - immunology Immunity Immunity (Disease) Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin Heavy Chains - immunology Immunoglobulin Variable Region - immunology Immunoglobulins Immunotherapy Ligands Lymphocytes B Major histocompatibility complex Medical schools Mutation Neoplasms - immunology Novels Performance evaluation Ribonucleic acid Risk factors RNA RNA sequencing Sequence Analysis, RNA - methods Somatic Hypermutation, Immunoglobulin - immunology Toxicity Tumors China
ISSN:	1061-4036, 1546-1718, 1546-1718
Online-Zugang:	Volltext
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